Effects of formaldehyde exposure on anxiety-like and depression-like behavior, cognition, central levels of glucocorticoid receptor and tyrosine hydroxylase in mice

Li, Yani; Song, Zhuoyi; Ding, Yujuan; Ye, Xin; Wu, Tong; Su, Tao; He, Rong; Tai, Fadao; Zhen-min, Lian

doi:10.1016/j.chemosphere.2015.10.102

Cited by 41 publications

(23 citation statements)

References 66 publications

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“…Epidemiological studies have shown that work-related exposure to FA leads to headaches, fatigue, anxiety, sleep disorders, and particularly cognitive disorders [44] [56]. Different concentrations of aerosolized formaldehyde lead to completely different effects on anxiety, depression-like behavior and cognition ability which can be related to alterations in hippocampal glucocorticoid receptors and brain tyrosine hydroxylase levels [57]. FA can react with the nerve proteins that referred to as neuroamines and neurotransmitters (as catecholamine) which might impair neurological system performance and may cause endocrine disruption [58].…”

Section: Clinical Studymentioning

confidence: 99%

Clinical and Experimental Study of the Toxic Neuropsychiatric Effects of Formaldehyde Exposure: Has Garlic a Protective Role?

Soliman¹,

Shalaby²,

Al-sayed³

et al. 2018

ODEM

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Background: The central nervous system is one of the most important systems affected by formaldehyde (FA). Aim of Work: This study was designed to assess its toxic neuropsychiatric effects both clinically and experimentally and the protective effects of garlic. Methods: Clinically: 20 workers in the gross anatomy laboratory and 20 libertarians underwent a standardized clinical assessment including medical, neurological and psychiatric examination. Experimental: 40 male rats were divided randomly into four groups. Group I is control group. Group II received 10 mg/kg of FA intraperitoneally once daily for 14 days. Group III was treated with fresh garlic juice (1 ml/100g body weight) once daily by oral gavage for 14 days. Groups VI received fresh garlic juice plus formaldehyde daily for 14 days. At the end of the experiment, the rats' brains were obtained for histological examination and biochemical analysis. Results: Clinical and psychiatric profile of FA exposed persons' revealed cognitive impaired, anxious and depressed persons. There were hostile persons with more hostility toward outside. Experimentally, hippocampal and frontal superoxide dismutase and reduced glutathione showed highly significant decrease while malondialdehyde and nitric oxide level showed highly significant increase in formaldehyde treated group when compared with control group. Also histopathological changes in the hippocampal and frontal cortices by light microscope revealed many distorted cells with deeply stained shrunked nuclei and cytoplasm was surrounded by vacuolated pale areas in FA exposed group. Minimization of biochemical and histopathological changes were observed in combined formaldehyde and garlic treated group. Conclusion: The profiles of personality arouse dangerous affairs about the toxic impact of FA on persons, family, and society. Formaldehyde-induced neuronal damage, oxidative stress and lipid peroxidation in brain were minimized by addition of garlic.

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Section: Clinical Studymentioning

confidence: 99%

Clinical and Experimental Study of the Toxic Neuropsychiatric Effects of Formaldehyde Exposure: Has Garlic a Protective Role?

Soliman¹,

Shalaby²,

Al-sayed³

et al. 2018

ODEM

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“…Besides, FA is included in tobacco smoke and smoke produced from photochemical reactions and burning of general combustibles (3). Growing evidences revealed that elongated exposure to FA causes chemical accumulation (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Protection with thymoquinone against formaldehyde-induced neurotoxicity in the rats

Saygin¹,

Eşrefoğlu²,

Bayındır³

et al. 2018

BLL

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INTRODUCTION: This study aimed to investigate the neurotoxic damage of formaldehyde (FA), which is commonly used in medicine and industrial fi elds, for the hippocampus of rats and the protective role of thymoquinone (TQ) against this neurotoxicity. METHODS: There were fi ve groups with eight rats in each. Two control groups were formed, in one of them physiological saline was applied and in the other one corn oil was applied. FA was injected in Group 3. Group 4 was exposed to FA and TQ simultaneously. Group 5 received TQ only. At the end of the experiment animals were sacrifi ced and brain tissues were removed for biochemical and histopathological investigation. RESULTS: Catalase (CAT), glutathione peroxidase (GSH-px) and superoxide dismutase (SOD), all known as enzymes with antioxidant activities, were increased in FA and TQ simultaneously administered group. FA caused prominent subarachnoidal hemorrhage and vacuolization. Vacuolization was not observed but occasional subarachnoidal hemorrhage was detected in the FA+TQ group. CONCLUSION: Neurotoxic damage in hippocampus induced by FA was reverted by administration of TQ (Tab.

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“…In addition, mice submitted to 13 week-exposure at 40 ppm exhibited dyspnea and ataxia (Maronpot et al, 1986[28]). A recent report has pointed out the possible onset of anxiety- and depression-like behaviors along with cognitive impairments in mice exposed to low doses of inhaled FA for one week (Li et al, 2016[26]). On the other hand, discrepant findings have been reported in experimental animals regarding the hematotoxic and immunotoxic outcomes of FA.…”

Section: Introductionmentioning

confidence: 99%

Effects of hesperidin on formaldehyde-induced toxicity in pregnant rats

Merzoug¹,

Toumi²

2017

EXCLI Journal; 16:Doc400; ISSN 1611-2156

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Effects of formaldehyde exposure on anxiety-like and depression-like behavior, cognition, central levels of glucocorticoid receptor and tyrosine hydroxylase in mice

Cited by 41 publications

References 66 publications

Clinical and Experimental Study of the Toxic Neuropsychiatric Effects of Formaldehyde Exposure: Has Garlic a Protective Role?

Clinical and Experimental Study of the Toxic Neuropsychiatric Effects of Formaldehyde Exposure: Has Garlic a Protective Role?

Protection with thymoquinone against formaldehyde-induced neurotoxicity in the rats

Effects of hesperidin on formaldehyde-induced toxicity in pregnant rats

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