Effects of flutropium bromide, a new antiasthma drug, on mediator release from mast cells and actions of mediators.

Misawa, Miwa; Yanaura, Saiζo; Hosokawa, Tomokazu; Mizuno, Hiroyuki; Irinoda, Kazuhiko; Takahashi, Yūzō; Yoshimura, Kuniko; Maruyama, Yutaka; Sugimoto, Kazunori; Ohno, Hiromitsu

doi:10.1254/fpj.91.97

Cited by 6 publications

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“…In addition to an anticholinergic action (14), flutropium can stabilize the cell mem brane (16) and has an antihistaminergic action (14,15). The anticholinergic action of flutro pium was stronger and longer lasting than that of atropine (14).…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported by Kimura et al (27) that orally administered flutropium was poorly absorbed in the gastrointestinal tract. Misawa et al (16) reported that i.v. injection of flutropium showed antiallergic action against the 48 hr homologous PCA in guinea pigs.…”

Section: Discussionmentioning

confidence: 99%

“…Guinea pig antiserum was prepared according to the method described by Misawa et al (16). Responses of the experimental allergic rhinitis were measured according to the method described by Kojima et al (4).…”

Section: Effects On Allergic Rhinitismentioning

confidence: 99%

“…Flutropium bromide (flutropium) is a new antiasthma drug possessing the quartemary ammonium salt structure of an atropine derivative. In addition to the anticho linergic action, flutropium has antihista minergic and antiallergic actions (14)(15)(16). However, there are very few experimental rhi nitis models in guinea pigs.…”

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confidence: 99%

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Effects of flutropium on experimental models of drug- and allergy-induced rhinitis in guinea pigs.

et al. 1991

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ABSTRACT-The effects of flutropium on histamine (Hist)-induced increase in intra nasal pressure in non-sensitized guinea pigs and nasal mucosa capillary permeability in passively sensitized guinea pigs were investigated. Flutropium (0.3%), atropine (0.3%), diphenhydramine (0.01%) and cimetidine (0.1%) were directly inhaled into the nasal cavities by an ultrasonic nebulizer for 20 min, followed by inhalation of Hist (0.1%) for 10 min. Flutropium, atropine and diphenhydramine had an inhibitory ac tion on the Hist-induced increase in intranasal pressure in guinea pigs. Cimetidine had no effect on this system. In passively sensitized guinea pigs (the challenge was per formed 48 hr after sensitization), a 0.1-1.0 mg/kg injection of flutropium (i.v.) dose dependently inhibited the allergic nasal mucosa capillary permeability. Atropine (10 mg/kg, i.v.) had no inhibitory action on this system. These results suggest that inhala tion into the nasal cavities and i.v. injection of flutropium are effective in ex perimental models of drug and allergy-induced rhinitis of the guinea pig.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Effects On Allergic Rhinitismentioning

confidence: 99%

mentioning

confidence: 99%

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Effects of flutropium on experimental models of drug- and allergy-induced rhinitis in guinea pigs.

et al. 1991

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“…In addition to anti cholinergic action, flutropium has anti histaminergic and anti-allergic actions (13,14). It is reported that flutropium given topically into the naso-oral tract as an aerosol shows a clinical efficacy in patients with nasal allergy and rhinorrhea (15)(16)(17)(18).…”

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Effects of Muscarinic Antagonists on Experimental Nasal Secretion in Guinea Pigs.

et al. 1991

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ABSTRACT-The effects of muscarinic antagonists on acetylcholine (ACh) and histamine-induced nasal secretion were investigated in guinea pigs. Inhalations of flut ropium (0.01 to 0.3%) and atropine (0.03 to 0.3%) into the nasal cavities dose-depend ently inhibited the nasal secretion induced by ACh. The inhibitory action of flutro pium was slightly stronger than that of atropine. Inhalations of pirenzepine (0.3%) and gallamine (0.3%) had no effect on the ACh-induced nasal secretion. However, 4 DAMP dose-dependently inhibited the nasal secretion induced by ACh. Inhalations of flutropium (0.3%) and diphenhydramine (0.3%) showed a similar inhibitory action on the histamine-induced nasal secretion. These results suggest that 1) inhalation into the nasal cavities of flutropium was effective in experimental model of ACh and histamine-induced nasal secretion, 2) M3 cholinergic receptors may be dominant in the nasal secretion induced by ACh and 3) the experimental model of drug-induced nasal secretion in guinea pigs used in the present study can be employed to develop therapeutic drugs for nasal secretion.

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Effects of Muscarinic Antagonists on Experimental Nasal Secretion in Guinea Pigs

Mizuno¹,

Iwase²,

Kawamura³

et al. 1991

Japanese Journal of Pharmacology

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Effects of flutropium bromide, a new antiasthma drug, on mediator release from mast cells and actions of mediators.

Cited by 6 publications

References 0 publications

Effects of flutropium on experimental models of drug- and allergy-induced rhinitis in guinea pigs.

Effects of flutropium on experimental models of drug- and allergy-induced rhinitis in guinea pigs.

Effects of Muscarinic Antagonists on Experimental Nasal Secretion in Guinea Pigs.

Effects of Muscarinic Antagonists on Experimental Nasal Secretion in Guinea Pigs

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