“…Different mediation mechanisms can be attributed to different symptoms in rhinitis model e.g. thromboxane A 2 and peptide leukotrienes in early and late phase nasal blockage [7], histamine H 1 receptors in sneezing and itching [8], histaminergic and cholinergic mechanisms in nasal secretion [9] and tachykinins in sneezing [10]. The molecular mechanisms in animal model of rhinitis or human rhinitis and the parallels between the two are incompletely understood, however, some symptoms of rhinitis such as sneezing, nose rubbing, nasal blockage and rhinorrhea can be modeled in experimental animals [11].…”