Effects of Fish Oil with a High Content of n-3 Polyunsaturated Fatty Acids on Mouse Gut Microbiota

Yu, Haining; Zhu, Jing; Pan, Wensheng; Shen, Shengrong; Shan, Wei‐Guang; Das, Undurti N.

doi:10.1016/j.arcmed.2014.03.008

Cited by 148 publications

(92 citation statements)

References 53 publications

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“…Consistent with previous individual studies of fish oil, we found that supplementation with krill oil and fish oil apparently changed the gut microbiota of HFD-induced obese mice [67]. Changes in the composition of the gut microbiota can be caused by various environmental disturbances, whereas the same environmental stress factors may elicit different responses from different bacterial species in the same genus [68].…”

Section: Discussionsupporting

confidence: 88%

Modulation of the gut microbiota by the mixture of fish oil and krill oil in high-fat diet-induced obesity mice

Cui

Gao

et al. 2017

PLoS ONE

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Previous studies confirmed that dietary supplements of fish oil and krill oil can alleviate obesity in mice, but the underlying mechanism remains unclear. This study aims to discern whether oil treatment change the structure of the gut microbiota during the obesity alleviation. The ICR mice received high-fat diet (HFD) continuously for 12 weeks after two weeks of acclimatization with a standard chow diet, and the mice fed with a standard chow diet were used as the control. In the groups that received HFD with oil supplementation, the weight gains were attenuated and the liver index, total cholesterol, triglyceride and low-density lipoprotein cholesterol were reduced stepwise compared with the HFD group, and the overall structure of the gut microbiota, which was modulated in the HFD group, was shifted toward the structure found in the control group. Moreover, eighty-two altered operational taxonomic units responsive to oil treatment were identified and nineteen of them differing in one or more parameters associated with obesity. In conclusion, this study confirmed the effect of oil treatment on obesity alleviation, as well as on the microbiota structure alterations. We proposed that further researches are needed to elucidate the causal relationship between obesity alleviation and gut microbiota modulation.

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Section: Discussionsupporting

confidence: 88%

Modulation of the gut microbiota by the mixture of fish oil and krill oil in high-fat diet-induced obesity mice

Cui

Gao

et al. 2017

PLoS ONE

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“…Undurti et al [10] studied the effect of fish oil with a high content of n-3 PUFA on mouse gut microbiota, and found that the fish oil treatment could change the gut microbiota. They proposed that this might be the potential mechanism of how n-3 PUFAs exert their biological effects.…”

Section: Discussionmentioning

confidence: 99%

“…The bioavailability of fatty acids is associated with gastrointestinal function, and alterations in their metabolism may cause mucosal inflammation and other gastrointestinal troubles [9]. Supplementation of n-3 PUFAs can improve gut function via interaction with the gut microbiota [10]. …”

Section: Introductionmentioning

confidence: 99%

Dietary intake of n-3 PUFAs modifies the absorption, distribution and bioavailability of fatty acids in the mouse gastrointestinal tract

Yang

Wang

et al. 2017

Lipids Health Dis

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BackgroundDietary polyunsaturated fatty acids (PUFAs), especially n-3 PUFAs, are important for human health. The intestinal tract, a location that is heavily colonized by microorganisms, is the main organ for absorbing fatty acids.MethodsThe purpose of this study was to analyze the effects of dietary n-3 and n-6 PUFAs on the distribution of different types of fatty acids and their bioavailability along the gut. Mice were fed for a week with experimental diets containing high n-3 or high n-6 fatty acid levels. Blood was collected at different time points, and after 7 days the mice were euthanized and their digestive tract was divided into 17 segments for fatty acids analyses.ResultsWe found that supplementing n-3 fatty acids significantly changed the ratio of n-6/n-3 PUFAs, increased the bioavailability of n-3 PUFAs, and altered fatty acid distribution. In addition, in the n-3 diet group, the absorption of saturated fatty acids (SFAs) along the gut was found to be inhibited, which was confirmed by feeding the mice with a diet containing deuterium-labeled palmitic acid and stearic acid.ConclusionThese results show that a diet rich in n-3 PUFAs can significantly modify the distribution and bioavailability of fatty acids, and particularly, may block the absorption of SFAs in the mouse gastrointestinal (GI) tract.Electronic supplementary materialThe online version of this article (doi:10.1186/s12944-016-0399-9) contains supplementary material, which is available to authorized users.

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“…At the same time, the dietary fatty acids can also directly or indirectly modulate the composition of gut microbiota and influence the host immune system. The composition of gut microbiota significantly changed in mice fed with -3 PUFAs enriched diet (Liu et al, 2012;Yu et al, 2014). So, on one hand, dietary -3 PUFAs may influence brain functions by changing the composition of gut microbiota.…”

Section: Diet Gut Microbiota and Admentioning

confidence: 97%

Alzheimer’s disease and gut microbiota

Wang

Jin

2016

Sci. China Life Sci.

293

188

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Effects of Fish Oil with a High Content of n-3 Polyunsaturated Fatty Acids on Mouse Gut Microbiota

Cited by 148 publications

References 53 publications

Modulation of the gut microbiota by the mixture of fish oil and krill oil in high-fat diet-induced obesity mice

Modulation of the gut microbiota by the mixture of fish oil and krill oil in high-fat diet-induced obesity mice

Dietary intake of n-3 PUFAs modifies the absorption, distribution and bioavailability of fatty acids in the mouse gastrointestinal tract

Alzheimer’s disease and gut microbiota

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