Effects of extracts of leaves from Sparattosperma leucanthum on hyperuricemia and gouty arthritis

Lima, Rita de Cássia Lemos; Ferrari, Fernanda Cristina; Souza, Maíra Ribeiro de; Pereira, Bruna Maria de Sá; Paula, Carmen Aparecida de; Saúde-Guimarães, Dênia Antunes

doi:10.1016/j.jep.2014.11.051

Cited by 31 publications

(15 citation statements)

References 30 publications

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“…In the present study, an experimental model of hyperuricemia induced by potassium oxonate was adopted according to Lemos Lima Rde C et al [46]. with modifications.…”

Section: Methodsmentioning

confidence: 99%

Hypouricemic and Nephroprotective Effects of an Active Fraction from Polyrhachis Vicina Roger On Potassium Oxonate-Induced Hyperuricemia in Rats

Nong

et al. 2018

Kidney Blood Press Res

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Background/Aims: The objective of this study is to evaluate the hypouricemic and nephroprotective effects of an active fraction from Polyrhachis vicina Roger (AFPR) in potassium oxonate-induced hyperuricemic rats. Methods: Hyperuricemia was induced by potassium oxonate in male rats. AFPR was orally administered to hyperuricemic rats for 12 consecutive weeks. Serum, liver and kidney samples were collected for effects and mechanism analysis. The levels of serum uric acid (SUA) were measured by the phosphotungstic acid method, xanthine oxidase (XOD) activity in the hepatic and serum samples were measured by ultraviolet spectrophotometry, serum levels of interleukin-1 (IL-1β), interleukin-1 (IL-6) and tumor necrosis factor-α (TNF-α) were measured by ELISA, the levels of serum creatinine (SCr), blood urea nitrogen (BUN), super oxide dismutase (SOD) and malondialdehyde (MDA) in serum were determined by colorimetric method. Protein expression of renal URAT1, GLUT9, and OAT1 were analyzed by Western blot. Results: AFPR significantly decreased the levels of SUA, serum and hepatic XOD, SCr, BUN, and MDA as well as increased SOD. In addition, AFPR treatment significantly reduced the levels of proinflammatory cytokines in serum, including IL-1β, IL-6 and TNF-α. Moreover, we found the significant decrease in protein expression of URAT1 and GLUT9, and the significant increase in protein expression of OAT1 in the kidney in AFPR treated groups compared to the model groups of hyperuricemia. Conclusion: These findings suggest that AFPR has anti-hyperuricemic activity attributed to the inhibition of uric acid generation in the liver and probably to the enhancement of urate excretion in the kidney, and possess nephroprotective effect in hyperuricemic rats due to its anti-inflammatory and antioxidant activities.

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“…In the present study, an experimental model of hyperuricemia induced by potassium oxonate was adopted according to Lemos Lima Rde C et al [46]. with modifications.…”

Section: Methodsmentioning

confidence: 99%

Hypouricemic and Nephroprotective Effects of an Active Fraction from Polyrhachis Vicina Roger On Potassium Oxonate-Induced Hyperuricemia in Rats

Nong

et al. 2018

Kidney Blood Press Res

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“…Antihyperuricemic activity of AEL, caffeic, and chlorogenic acids was evaluated as described elsewhere and their description is adapted from our previous work [ 10 , 17 – 19 ]. Substances were solubilized in vehicle [DMSO : Tween 80 : water (1 : 1 : 8)].…”

Section: Methodsmentioning

confidence: 99%

“…Enzyme extraction was performed as described elsewhere [ 10 , 18 , 19 ]. Briefly, livers were homogenized with 5 mL of 50 mM sodium phosphate buffer (pH 7.4).…”

Section: Methodsmentioning

confidence: 99%

Effects of the Aqueous Extract from Tabebuia roseoalba and Phenolic Acids on Hyperuricemia and Inflammation

Ferraz-Filha

Ferrari

Araújo

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Tabebuia species (Bignoniaceae) have long been used in folk medicine as anti-inflammatory, antirheumatic, antimicrobial, and antitumor. The aim of this study was to investigate if aqueous extract from the leaves (AEL) of Tabebuia roseoalba (Ridl.) Sandwith, Bignoniaceae, and its constituents could be useful to decrease serum uric acid levels and restrain the gout inflammatory process. HPLC analysis identified caffeic acid and chlorogenic acid in AEL. Antihyperuricemic effects and inhibition of liver XOD (xanthine oxidoreductase) by AEL and identified compounds were evaluated in hyperuricemic mice. Anti-inflammatory activity was evaluated on MSU (monosodium urate) crystal-induced paw edema. In addition, AEL antioxidant activity in vitro was evaluated. AEL, caffeic, and chlorogenic acids were able to reduce serum uric acid levels in hyperuricemic mice probably through inhibition of liver xanthine oxidase activity and significantly decreased the paw edema induced by MSU crystals. AEL showed significant antioxidant activity in all evaluated assays. The results show that the AEL of Tabebuia roseoalba can be a promising agent for treatment for gout and inflammatory diseases. We suggest that caffeic and chlorogenic acids may be responsible for the activities demonstrated by the species.

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“…Each assay was performed in triplicate. The residual activity of XO in the mouse liver and serum was determined spectrophotometrically by monitoring uric acid formation from xanthine . Mice livers (0.5 g) were homogenized in an 1 ml aliquot of 50 m m sodium phosphate buffer (pH 7.4).…”

Section: Methodsmentioning

confidence: 99%

“…Hyperuricemia is characterized by increased uric acid blood levels due to a dysfunction in its production or excretion. Uric acid is the final metabolite of purine compounds, which is formed by the oxidation of hypoxanthine to xanthine and xanthine to uric acid by xanthine oxidase (XO) . Gout is a metabolic disorder that is associated with high levels of uric acid in the body, which can cause inflammation, gouty arthritis and uric acid nephrolithiasis .…”

Section: Introductionmentioning

confidence: 99%

Effects of extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos on xanthine oxidase activity and hyperuricemia

Yoon

Park

et al. 2016

Journal of Pharmacy and Pharmacology

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Effects of extracts of leaves from Sparattosperma leucanthum on hyperuricemia and gouty arthritis

Cited by 31 publications

References 30 publications

Hypouricemic and Nephroprotective Effects of an Active Fraction from <b><i>Polyrhachis Vicina Roger</i></b> On Potassium Oxonate-Induced Hyperuricemia in Rats

Hypouricemic and Nephroprotective Effects of an Active Fraction from <b><i>Polyrhachis Vicina Roger</i></b> On Potassium Oxonate-Induced Hyperuricemia in Rats

Effects of the Aqueous Extract from Tabebuia roseoalba and Phenolic Acids on Hyperuricemia and Inflammation

Effects of extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos on xanthine oxidase activity and hyperuricemia

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