Effects of extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos on xanthine oxidase activity and hyperuricemia

Abstract

This study is the first report on the XO inhibitory and antihyperuricemic effects of C. coreana Uyeki flos extract, which can be therapeutically applied in treating hyperuricemia and gout.

Quantitative Analysis, Extraction Optimization, and Biological Evaluation of Cudrania tricuspidata Leaf and Fruit Extracts

“…The total flavonoid content was determined by an aluminum chloride assay [ 20 ] and was reported as quercetin equivalents by reference to a standard curve ( r 2 > 0.999), as shown in Figure 4 . The flavonoid content in the 100% ethanolic extract was greater than that in the other ethanolic extracts.…”

Natural compounds with xanthine oxidase inhibitory activity: A review

“…Yoon, Park, Ki, and Cho () discussed that flavonoid (quercetin) from the Corylopsis coreana Uyeki flos extract has the potential to combat HUA. Salem et al.…”

“…Aspalathin contained 2′,4′,6′‐OH groups at A ring and inhibited XOD in a competitive manner ( K i : 3.1 μM) (Kondo et al., ). Isosalipurposide isolated from the ethanolic extract of C. coreana Uyeki also possessed XOD inhibitory activity (Yoon et al., ).…”

“…Chalcones are the precursors of flavonoids and isoflavonoids (Figure 9) (Seo et al, 2005;Tung & Chang, 2010;Yoon et al, 2016). Tung and Chang (2010) reported that chalcone (okanin) from Acacia confusa showed greater inhibitory activity than other isolated flavone compounds.…”

“…Aspalathin contained 2′,4′,6′-OH groups at A ring and inhibited XOD in a competitive manner (K i : 3.1 μM) (Kondo et al, 2013). Isosalipurposide isolated from the ethanolic extract of C. coreana Uyeki also possessed XOD inhibitory activity (Yoon et al, 2016). Lin, Qu, and Liang (2011) isolated four saponins from the ethanolic (50% and 75%) roots extracts of Ilex pubescens (Aquifoliaceae) and evaluated for XOD inhibitory activities (Table 2).…”