Nutritional and medicinal plants as potential sources of enzyme inhibitors toward the bioactive functional foods: an updated review

Saleem, Hammad; Yaqub, Atif; Rafique, Rafaila; Chohan, Tahir Ali; Malik, Durr-e-shahwar; Tousif, Muhammad Imran; Khurshid, Umair; Ahemad, Nafees; Ramasubburayan, Ramasamy; Rengasamy, Kannan R.R.

doi:10.1080/10408398.2023.2217264

Cited by 11 publications

(5 citation statements)

References 134 publications

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“…16 Flavonoids have been reported to exhibit significant antioxidant and antiinflammatory activities which portends great medicinal importance owing to the association of oxidative stress and inflammation in the pathophysiology of numerous diseases. 51 Saleem et al 52,53 previously reported that phenolic and polyphenolic compounds hold great importance among phytochemicals and constitute a significant amount of natural phytoproducts in foods.…”

Section: Discussionmentioning

confidence: 99%

Ninety-Day Toxicological Assessment of Preparation of the Medicinal Plant Newbouldia laevis (P. Beauv.) Seem. (Bignoniaceae) in Rats

Murtala,

Akindele,

Oreagba

2024

Natural Product Communications

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Objectives To investigate the safety profile of subchronic oral administration of hydroethanol leaf extract of Newbouldia laevis (NL) in rats. Methods NL was administered orally (20, 100, and 500 mg/kg) to groups of rats for 90 days. Distilled water served as control. Some rats were spared for an extra 30 days with no extract administration (reversibility study). Blood, urine and selected vital organs were collected for analyses. Results In male rats, NL (20, 500 mg/kg) irreversibly increased ( P˂.05) bodyweight and feeding pattern with opposite trend of results in females. NL (20 mg/kg) elicited irreversible decrease ( P˂0.05) in RBC in male rats; a reversible decrease in RBC and Hb, and an irreversible increase (500 mg/kg) in WBC and neutrophils in females. In male rats, NL irreversibly decreased ( P˂.01) HDL-c and increased uric acid; in female rats, it elicited a reversible increase ( P˂.05, 500 mg/kg) in AST. NL (500 mg/kg) irreversibly decreased ( P˂.05) sperm motility and count, and produced an irreversible increase ( P˂.01) in testosterone levels in male rats (100 mg/kg). It reversibly decreased (20-500 mg/kg) luteinizing hormone levels (both sexes). Conclusions NL is fairly safe at lower doses. However, it could cause anemia at lower doses, infertility (both sexes), liver and kidney injuries at high doses.

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Section: Discussionmentioning

confidence: 99%

Ninety-Day Toxicological Assessment of Preparation of the Medicinal Plant Newbouldia laevis (P. Beauv.) Seem. (Bignoniaceae) in Rats

Murtala,

Akindele,

Oreagba

2024

Natural Product Communications

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“…Flavonoids are the most abundant group of plant polyphenolic compounds; they play a vital role in plant physiology [35] and are commonly found as glycosides bound to one or more sugar moieties through C-and/ or O-linkage. Increasing scientific evidence suggested that flavonoids could have antioxidant and anti-inflammatory potential by suppressing regulatory enzymes or transcription factors implicated in the control of inflammatory mediators [36]. They exhibited neuroprotective effects against different neurodegenerative diseases, including Alzheimer, Parkinson, multiple sclerosis, and others through inhibiting pro-inflammatory cytokines expression, inflammatory markers, and thus preventing neural damage [37].…”

Section: Identification Of Flavonoidsmentioning

confidence: 99%

LC-MS/MS profiling of Tipuana tipu flower, HPLC-DAD quantification of its bioactive components, and interrelationships with antioxidant, and anti-inflammatory activity: in vitro and in silico approaches

Ibrahim,

Abdel-Baki,

El-Rashedy

et al. 2024

BMC Complement Med Ther

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Background Fabaceae plays a crucial role in African traditional medicine as a source of large number of important folk medication, agriculture and food plants. In a search of potential antioxidant and anti-inflammatory candidates derived from locally cultivated plants, the flowers of Tipuana tipu (Benth.) Lillo growing in Egypt were subjected to extensive biological and phytochemical studies. The impact of the extraction technique on the estimated biological activities was investigated. Methods The flowers were extracted using different solvents (aqueous, methanol, water/methanol (1:1), methanol/methylene chloride (1:1), and methylene chloride). The different extracts were subjected to antioxidant (DPPH, ABTS, and FRAP) and anti-inflammatory (COX-2 and 5-LOX) assays. The methanol extract was assessed for its inhibitory activity against iNOS, NO production, and pro-inflammatory cytokines (NF-KB, TNF-R2, TNF-α, IL-1β, and IL-6) in LPS-activated RAW 264.7 macrophages. The composition-activity relationship of the active methanol extract was further investigated using a comprehensive LC–QTOF-MS/MS analysis. The major identified phenolic compounds were further quantified using HPLC-DAD technique. The affinity of representative compounds to iNOS, COX-2, and 5-LOX target active sites was investigated using molecular docking and molecular dynamics simulations. Results The methanol extract exhibited the highest radical scavenging capacity and enzyme inhibitory activities against COX-2 and 5-LOX enzymes with IC50 values of 10.6 ± 0.4 and 14.4 ± 1.0 µg/mL, respectively. It also inhibited iNOS enzyme activity, suppressed NO production, and decreased the secretion of pro-inflammatory cytokines. In total, 62 compounds were identified in the extract including flavonoids, coumarins, organic, phenolic, and fatty acids. Among them 18 phenolic compounds were quantified by HPLC-DAD. The highest docking scores were achieved by kaempferol-3-glucoside and orientin. Additionally, molecular dynamics simulations supported the docking findings. Conclusion The flower could be considered a potentially valuable component in herbal medicines owing to its unique composition and promising bioactivities. These findings encourage increased propagation of T. tipu or even tissue culturing of its flowers for bioprospecting of novel anti-inflammatory drugs. Such applications could be adopted as future approaches that benefit the biomedical field.

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“…Also, it has been well documented that plant-based products act as enzyme inhibitors that bind to enzymes and decrease or block their bioactivity. Many natural products constitute dynamic fields of pharmacology and biochemistry due to the discovery and development of enzyme inhibitors that can be used in the treatment of metabolic disorders (Saleem et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

An Investigation of the Ace Inhibitory Activity, Antioxidant Capacity, and Phytochemical Constituents of Polar and Non-Polar Extracts of Ziziphus Jujuba Fruit: Statistical Screening the Main Components Responsible for Bioactivity

Fındık,

Yıldız,

Birişçi

et al. 2024

Gıda

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Herein, the angiotensin I-converting enzyme (ACE) inhibitory activity, antioxidant capacity, total polyphenol contents (TPC), and phytochemical profiles of polar and non-polar extracts of dried Ziziphus jujuba fruits were investigated, along with the statistical determination of the main components responsible for ACE inhibitory activity. The non-polar extract expressed the strongest ACE inhibitory activity (99.81%) among the extracts. The non-polar extract also exhibited the highest DPPH scavenging activity (IC50 of 30.63), linoleic acid/β-carotene bleaching capacity (89.31%), and TPC (59.47 mg GAE/g). The phenolic profiles of the extracts were identified by LC-MS/MS, and the presence of seven triterpenoid species in the extracts was examined using GC-MS techniques. The principal constituents included 19 phenolics, 2 organic acids, and 4 triterpenoids. A Pearson correlation and principal component analysis were conducted to find the correlation between individual phenolic compounds and ACE inhibitory activity.

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Nutritional and medicinal plants as potential sources of enzyme inhibitors toward the bioactive functional foods: an updated review

Cited by 11 publications

References 134 publications

Ninety-Day Toxicological Assessment of Preparation of the Medicinal Plant Newbouldia laevis (P. Beauv.) Seem. (Bignoniaceae) in Rats

Ninety-Day Toxicological Assessment of Preparation of the Medicinal Plant Newbouldia laevis (P. Beauv.) Seem. (Bignoniaceae) in Rats

LC-MS/MS profiling of Tipuana tipu flower, HPLC-DAD quantification of its bioactive components, and interrelationships with antioxidant, and anti-inflammatory activity: in vitro and in silico approaches

An Investigation of the Ace Inhibitory Activity, Antioxidant Capacity, and Phytochemical Constituents of Polar and Non-Polar Extracts of Ziziphus Jujuba Fruit: Statistical Screening the Main Components Responsible for Bioactivity

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