Effects of ethanol on hippocampal function during adolescence: a look at the past and thoughts on the future

Chin, Vivien S.; Skike, Candice E. Van; Matthews, Douglas B.

doi:10.1016/j.alcohol.2009.10.015

Cited by 46 publications

(39 citation statements)

References 164 publications

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“…It is known that addictive behavior among adults usually has its roots in abuse of both alcohol and tobacco during adolescence [9,18,20,21,24,41]. Additionally, smoking and drinking seem to increase the odds of the development of abuse of other substances, regardless of gender or age [17,27,29,38,40,49,61,62]. In our study, we observed a higher frequency and intensity of alcohol use among smokers, which corresponds well with previously published results.…”

Section: Discussionsupporting

confidence: 82%

Alcohol consumption among adolescents in Kraljevo, Serbia

2011

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AbstractThe aim of this study was to investigate the prevalence and predictors of alcohol consumption among adolescents in one town in Central Serbia. A questionnaire was used to obtain data from 191 Serbian students aged 18 years regarding personal experience with alcohol consumption and cigarette smoking, along with sociodemographics data. Alcohol consumption was reported by 97.4% subjects, with 34.9% having the first experience with alcohol at the age of 14 years or less. Binge drinking (the intake of five or more drinks at one sitting) was reported by 37.8% subjects. Significantly higher consumption of beer (p<0.0001) and spirits (p=0.03) was observed in boys. The most common reason for both initiation and continuation of drinking, regardless of gender, were celebrations (p≥0.12). Smokers were more likely than nonsmokers to consume all alcoholic beverages more frequently (p≤0.04) and in larger quantities (p≤0.004). More frequent or more extensive alcohol consumption, or both, was associated in boys with frequent going out and socializing (p≤0.01), close peer relationship (p=0.04), alcohol abuse within the immediate environment (p≤0.04), better financial status of family (p=0.04), and parental criticism (p≤0.02); in girls, it was associated with parental disapproval (p≤0.02), alcohol abuse within the immediate environment (p≤0.04), and general discontentedness (p=0.049). Regardless of gender, positive alcohol outcome expectancies increased alcohol consumption (p≤0.048), and negative expectancies decreased intake (p≤0.047).

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Section: Discussionsupporting

confidence: 82%

Alcohol consumption among adolescents in Kraljevo, Serbia

2011

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“…Moreover, CCND2 is the only cyclin isoform known to express in the hippocampus and regulates neurogenesis in the hippocampus of the adult brain (13). Chronic use of ethanol is known to target the hippocampus and its associated physiological functions (37). Several studies have shown that miRNAs play an important role in the regulation of neurogenesis (11,38,39), and interestingly, our in silico studies (supplemental Fig.…”

Section: Discussionmentioning

confidence: 80%

miR-497 and miR-302b Regulate Ethanol-induced Neuronal Cell Death through BCL2 Protein and Cyclin D2

Yadav

Pandey

Shukla

et al. 2011

Journal of Biological Chemistry

134

107

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Background: Ethanol-induced neuronal apoptosis causes brain shrinkage and cognitive defects. Results: Exposure to ethanol (0.5% v/v for 72 h) in SH-SY5Y cells induced expression of miR-497 and miR-302b and downregulated expression of BCL2 and/or cyclin D2. Conclusion: Ethanol-induced neuronal apoptosis follows both the mitochondria-mediated and non-mitochondria-mediated pathways. Significance: Our study shows that miRNAs are involved in regulation of ethanol neurotoxicity.

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“…A C C E P T E D ACCEPTED MANUSCRIPT 5 In concordance with age-related effects of alcohol in humans, research using animal models has shown that many of the effects of alcohol are age-dependent (Chin, Van Skike, & Matthews, 2010 for review). Adolescent rats, compared to adult rats, have been shown to be less sensitive to the sedative (Little, Kuhn, Wilson, & Swartzwelder, 1996), anxiogenic (Doremus, Brunell, Varlinskaya, & Spear, 2003), hypnotic (Matthews, Tinsley, Diaz-Granados, Tokunaga, & Silvers, 2008;Silveri & Spear, 1998), and motor impairing effects of acute alcohol (Ramirez & Spear, 2010;Van Skike et al, 2010;White et al, 2002).…”

Section: A N U S C R I P Tmentioning

confidence: 97%