The effects of acute alcohol on motor impairments in adolescent, adult, and aged rats

Ornelas, Laura C.; Novier, Adelle; Skike, Candice E. Van; Diaz-Granados, Jaime L.; Matthews, Douglas B.

doi:10.1016/j.alcohol.2014.12.002

Cited by 30 publications

(19 citation statements)

References 44 publications

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“…Though the literature concerning the hypnotic effects of ethanol in aged rats is limited, there is evidence for acute ethanol increasing sleep time in aged versus young animals. Based on trajectories of BECs and accounting for the higher dose in our study, extending testing past our tissue collection point would have likely revealed differences in time of awakening as ethanol was further metabolized (Ornelas, Novier, Van Skike, Diaz-Granados, & Matthews, 2015). …”

Section: Discussionmentioning

confidence: 99%

A cross-sectional comparison of ethanol-related cytokine expression in the hippocampus of young and aged Fischer 344 rats

Gano

Doremus-Fitzwater

Deak

2017

Neurobiology of Aging

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Our work in Sprague Dawley rats has shown rapid alterations in neuroimmune gene expression (RANGE) in the hippocampus and paraventricular nucleus of the hypothalamus (PVN). These manifest as increased Interleukin (IL)-6 and IκBα, and suppressed IL-1β and Tumor necrosis factor alpha (TNFα) during acute ethanol intoxication. The present studies tested these effects across the lifespan (young adulthood at 2–3 months; senescence at 18 and 24 months), as well as across strain (Fischer 344) and sex. The hippocampus revealed age-dependent shifts in cytokine expression [IL-6, IL-1β, Monocyte chemoattractant protein 1], but no changes observed in the PVN at baseline or following ethanol. RANGE in adults was similar across sex and comparable to effects seen in Sprague Dawley rats. Plasma corticosterone levels increased with age, while the blood ethanol concentrations and loss of righting reflex were similar in all groups older than 2 months. These findings indicate that the RANGE effect is largely conserved across strain and is durable across age, even in the face of a shifting neuroimmune profile that emerges during immunosenescence.

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Section: Discussionmentioning

confidence: 99%

A cross-sectional comparison of ethanol-related cytokine expression in the hippocampus of young and aged Fischer 344 rats

Gano

Doremus-Fitzwater

Deak

2017

Neurobiology of Aging

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“…Two animals from the saline self‐administration group failed to lose their righting reflex and were excluded from the final analysis. The dose and timing of alcohol injections and the criteria for regaining the righting reflex were based on previous studies (Ornelas et al ).…”

Section: Methodsmentioning

confidence: 99%

Methamphetamine self‐administration reduces alcohol consumption and preference in alcohol‐preferring P rats

et al. 2016

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Subclinical levels of polysubstance use are a prevalent and understudied phenomenon. Alcohol is a substance commonly co‐used with other substances of other drug classes. These studies sought to determine the consumption effects of combining alcohol drinking and methamphetamine (MA) self‐administration. Male alcohol‐preferring P rats had continuous access to a two‐bottle alcohol drinking procedure in the home cage. Control rats remained alcohol naïve. Rats were also surgically implanted with intra‐jugular catheters and trained to self‐administer saline (control) or MA in daily 2‐hour sessions. We first measured the acquisition and maintenance of MA intake in alcohol‐consuming or control rats. MA intake was initially enhanced by alcohol consumption on a fixed ratio 1 schedule of reinforcement, but this effect did not prevail as the difficulty of the schedule (FR5 and progressive ratio) was increased. We next measured both alcohol consumption and preference before, during and after MA (or saline) self‐administration. MA self‐administration significantly reduced alcohol intake and preference ratios, a robust effect that persisted across several experimental variations. Interestingly, alcohol consumption rebounded following the cessation of MA self‐administration. The effects of MA self‐administration were specific to alcohol intake because it did not alter total fluid consumption or consumption of sucrose. MA self‐administration did not impact blood‐alcohol concentrations or alcohol‐induced loss of righting reflex suggesting no effect of MA intake on the alcohol metabolism or sensitivity. Together, the results suggest that MA intake disrupts alcohol consumption and preferences but not the reverse in alcohol‐preferring P rats.

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“…Chronic mouse models of FASD have shown that prenatal ethanol exposure can alter motor functioning (Ornelas, Novier, Van Skike, Diaz‐Granados, & Matthews, ), learning and memory (Marquardt & Brigman, ), and social behaviors (Varlinskaya & Mooney, ). However, fewer research studies have used an acute ethanol exposure model to study behavior, so effects of acute ethanol exposure therefore remain somewhat less certain.…”

Section: Introductionmentioning

confidence: 99%

“…Chronic mouse models of FASD have shown that prenatal ethanol exposure can alter motor functioning (Ornelas, Novier, Van Skike, Diaz-Granados, & Matthews, 2015), learning and memory (Marquardt & Brigman, 2016), and social behaviors (Varlinskaya & Mooney, 2014).…”

Section: Introductionmentioning

confidence: 99%

Acute ethanol exposure during late mouse neurodevelopment results in long‐term deficits in memory retrieval, but not in social responsiveness

2017

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ObjectivePrenatal alcohol exposure can result in neurological changes in affected individuals and may result in the emergence of a broad spectrum of neurobehavioral abnormalities termed fetal alcohol spectrum disorders (FASD). The effects of ethanol exposure during development are both time and dose dependent. Although many animal models of FASD use more chronic ethanol exposure, acute developmental alcohol exposure may also cause long‐lasting neuronal changes. Our research employed behavioral measures to assess the effects of a single early postnatal ethanol intoxication event in mice.Materials and MethodsMice were dosed at postnatal day 6 (a 2.5 g/kg dose of ethanol or a saline control administered twice, 2 hr apart) as a model of third trimester binge drinking in humans. This exposure was followed by behavioral assessment in male mice at 1 month (1M) and at 4 months of age (4M), using the Barnes maze (for learning/memory retrieval), exploratory behavior, and a social responsiveness task.ResultsEthanol‐exposed mice appeared to be less motivated to complete the Barnes maze at 1M, but were able to successfully learn the maze. However, deficits in long‐term spatial memory retrieval were observed in ethanol‐exposed mice when the Barnes maze recall was measured at 4M. No significant differences were found in open field behavior or social responsiveness at 1M or 4M of age.ConclusionsAcute ethanol exposure at P6 in mice leads to mild but long‐lasting deficits in long‐term spatial memory. Results suggest that even brief acute exposure to high ethanol levels during the third trimester equivalent of human pregnancy may have a permanent negative impact on the neurological functioning of the offspring.

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The effects of acute alcohol on motor impairments in adolescent, adult, and aged rats

Cited by 30 publications

References 44 publications

A cross-sectional comparison of ethanol-related cytokine expression in the hippocampus of young and aged Fischer 344 rats

A cross-sectional comparison of ethanol-related cytokine expression in the hippocampus of young and aged Fischer 344 rats

Methamphetamine self‐administration reduces alcohol consumption and preference in alcohol‐preferring P rats

Acute ethanol exposure during late mouse neurodevelopment results in long‐term deficits in memory retrieval, but not in social responsiveness

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