Effects of estrogen deficiency on tooth movement after force application: an experimental study in ovariectomized rats

As the number of elderly orthodontic patients increases, the impact of postmenopausal osteoporosis on orthodontic tooth movement (OTM) has attracted a great deal of attention because OTM relies on alveolar bone remodeling. The question of whether OTM causes subsequent alveolar bone loss and is harmful to alveolar bone health under osteoporotic conditions remains to be answered. The present study aimed to clarify the influences of OTM on alveolar bone in osteoporotic rats. OTM was accelerated in ovariectomized (OVX) rats as a result of increased bone resorption in the pressure area. At the same time, anabolic bone formation was promoted in the tension area during OTM in OVX rats. Micro-CT analysis of alveolar bone revealed a decrease in BMD, BV/TV and Tb.Th. in the OTM group compared with that in non-OTM rats on day 21 of OTM, suggesting that OTM caused alveolar bone loss in OVX rats during OTM. However, the OTM-induced bone loss could be recovered 3 months after OTM in OVX rats. Thus, our findings suggest that increased osteogenesis may compensate for the increased bone resorption during and after OTM and enable effective accelerated OTM in OVX rats.

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“…Arslan et al . observed an increase in the number of osteoclasts in the periodontal tissue during accelerated OTM in OVX rats 17 . Tan et al .…”

Section: Introductionmentioning

confidence: 86%

“…It has been reported that estrogen deficiency accelerates OTM in OVX rats 2, 5, 17–20 . Arslan et al .…”

Section: Introductionmentioning

confidence: 98%

Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats

Dai

Zhou

Zhang

et al. 2017

Sci Rep

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“…The impressions (Express TM STD, 3M ESPE, U.S.A.) of the upper jaw of all animals were taken with an individual acrylic impression tray on the 1 st day of the experiment. The previous studies have used the incisors in rats as an experimental model for exploring the effect of pharmaco-therapeutic agents on orthodontic tooth movement [13,14]. After the impression had been taken, an elastic band (elastic separator Ø 1.5 mm Dentalastics  Separators, Dentaurum, Germany) was inserted between the incisors.…”

Section: Samplesmentioning

confidence: 99%

“…The upper jaws were dissected and the separation of the right and left maxilla was performed with a diamond separator (Diamantscheibe 30 mm Ø, Bredent, Germany). The same region was excised in all rats, along the upper left central incisor root toward the apex of the alveolar bone on the mesial and distal sides, 3 mm above the apex towards the crown, as per previously described method [13].…”

Section: Histological Examinationmentioning

confidence: 99%

Dose- and time-dependent effects of clodronate on orthodontic tooth movement

Nakaš

Lauc

Tiro

et al. 2017

Bosn J of Basic Med Sci

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Orthodontic tooth movement is the result of bone remodeling that occurs in periodontal ligament and alveolar bone tissue as a response to mechanical loading of the tooth. The aim of this study is to investigate the time- and dose-response effects of locally administered clodronate on tooth movement. Sixty Wistar rats were randomly assigned to 4 groups of 15 specimens: E1 - application of 10 mMol of clodronate in 3-day intervals; E2 - application of 2.5 mMol of clodronate in 3-day intervals; E3 - application of 10 mMol of clodronate in 7-day intervals; E4 - application of 2.5 mMol of clodronate in 7-day intervals. A 50 μL clodronate solution was injected into a subperiosteal area to the right maxillary incisor. The left maxillary incisor served as a control, with an injection of saline solution. In 3-day interval application regime, there was no effect of clodronate dosing on tooth movement. In 7-day interval application regime, decreased tooth movement was observed with 10 mMol compared with 2.5 mMol clodronate concentration. However, decreased tooth movement was also observed when 2.5 mMol of clodronate was applied in 7-versus 3-day intervals. Conversely, no difference was observed when 10 mMol concentration was applied in 3- versus 7-day intervals. When clodronate is applied subperiosteally in the root area, it decreases the tooth movement. Tooth movement is impeded by the higher clodronate dosing, as well as by shorter application interval even with lower dosing. The purpose of future trials should, therefore, be to determine a safe therapeutic dose/interval application of clodronate in humans and their potential side effects.

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“…[ 8 9 ] Therefore, orthodontists need to be aware of any possible chronic medical conditions that might interfere with overall success of orthodontic treatments. To date, various systematic factors such as different hormonal changes including hyperparathyroidism,[ 10 ] hyper and hypothyroidism,[ 11 12 ] calcium-deficient,[ 13 ] and ovariectomization[ 14 15 16 ] have also been implicated as potential risk factors to individualize the prediction of each patient's risk of developing EARR, but the result remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Correlation of vitamin D status and orthodontic-induced external apical root resorption

et al. 2017

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Background:Adequate Vitamin D is essential for dental and skeletal health in children and adult. The purpose of this study was to assess the correlation of serum Vitamin D level with external-induced apical root resorption (EARR) following fixed orthodontic treatment.Materials and Methods:In this cross-sectional study, the prevalence of Vitamin D deficiency (defined by25-hydroxyvitamin-D) was determined in 34 patients (23.5% male; age range 12–23 years; mean age 16.63 ± 2.84) treated with fixed orthodontic treatment. Root resorption of four maxillary incisors was measured using before and after periapical radiographs (136 measured teeth) by means of a design-to-purpose software to optimize data collection. Teeth with a maximum percentage of root resorption (%EARR) were indicated as representative root resorption for each patient. A multiple linear regression model and Pearson correlation coefficient were used to assess the association of Vitamin D status and observed EARR. P < 0.05 was considered statistically significant.Results:The Pearson coefficient between these two variables was determined about 0.15 (P = 0.38). Regression analysis revealed that Vitamin D status of the patients demonstrated no significant statistical correlation with EARR, after adjustment of confounding variables using linear regression model (P > 0.05).Conclusion:This study suggests that Vitamin D level is not among the clinical variables that are potential contributors for EARR. The prevalence of Vitamin D deficiency does not differ in patients with higher EARR. These data suggest the possibility that Vitamin D insufficiency may not contribute to the development of more apical root resorption although this remains to be confirmed by further longitudinal cohort studies.

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Effects of estrogen deficiency on tooth movement after force application: an experimental study in ovariectomized rats

Abstract: Estrogen deficiency increased orthodontic tooth movements but counts of osteoblasts, which are responsible for new bone formation, were lower in regions of tension and of pressure.

Cited by 25 publications

References 17 publications

Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats

Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats

Dose- and time-dependent effects of clodronate on orthodontic tooth movement

Correlation of vitamin D status and orthodontic-induced external apical root resorption

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