Effects of estradiol and progesterone on the synthesis of collagen in corrosive esophageal burns in rats

Demirbilek, Semra; Bernay, Ferit; Rizalar, Rıza; Barış, Sancar; Gürses, N.

doi:10.1016/0022-3468(94)90136-8

Cited by 53 publications

(52 citation statements)

References 15 publications

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“…Pharmacological agents such as steroids, penicillamine, heparin, indomethacin, epidermal growth factor, gamma interferon, N-acetylcysteine, estrogen, progesterone, antibiotics, and their combinations are used to suppress inflammation and collagen synthesis, and to prevent fibroplasia and stricture formation. Despite the decrease in stricture formation in these experimental studies, the rate of stricture formation seen in advanced-grade corrosive esophagitis is still 70-100% (6)(7)(8)(14)(15)(16)(17)(18)(19)(20). Although the experimental studies have documented the efficiency of multiple agents, the current treatment protocol in corrosive esophagitis is still restricted to steroid, antibiotics and neutralization of the caustic agent in the early phase (13,(21)(22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

“…Today, the aim of therapy in corrosive esophagitis is to avoid development of perforation, fibrosis and stricture formation. Stricture formation can be prevented by suppressing fibrosis and scar formation (6). In Grades 1 and 2a corrosive esophagitis, stricture formation is rarely seen, whereas it is common in Grades 2b and 3 esophagitis (4).…”

Section: Introductionmentioning

confidence: 99%

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The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study

Gümürdülü¹,

Karakoç²,

Kara³

et al. 2010

Turk J Gastroenterol

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study

Gümürdülü¹,

Karakoç²,

Kara³

et al. 2010

Turk J Gastroenterol

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“…However, enough preventive effects were not found (Cakmak et al 1997;Ulman and Mutaf 1998). It was also reported in experimental model that estradiol and progesteron, ketotifen, Caffeicacid Phenyl Ester (CAPE), Epidermoid Growth Factor (EGF) inhibited collagen synthesis, but, these have not been used in clinic (Demirbilek et al 1994;Koltuksuz et al 2001;Yukselen et al 2004). Very few studies were found to investigate the acute phase of corrosive esophagitis (Gunel et al 1999;Ozel et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Trapidil, an Inhibitor for Phosphodiesterase and Platelet-Derived-Growth Factor, Ameliorates Corrosive Esophageal Burn in Rats

Somuncu

Çakmak

Erdoğan

et al. 2005

Tohoku J. Exp. Med.

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burn is a common health problem in the pediatric age group and causes serious esophageal injuries. The medical treatment in acute phase of corrosive esophageal injury is of particular importance for prevention of esophageal stricture. We therefore aimed to investigate the possible beneficial effect of trapidil (triazolopyrimidine), an inhibitor for phosphodiesterase and platelet-derived-growth-factor, during acute phase of esophageal corrosive injury. Wistar albino rats were randomly allocated to untreated, treated, and sham-operated groups (n = 10 for each group). Corrosive esophageal burn was generated with 10% NaOH solution. The rats were left untreated (untreated group) or treated with trapidil as a single dose of 40 mg/kg intraperitoneally after one hour of the injury (treated group). Abdominal esophageal segment was isolated and tied in sham-control group. The studied esophageal segment was removed from each animal after 24 hours. Malondialdehyde (MDA) and nitric oxide (NO) levels were measured in the esophageal tissues. The ulcer depth was graded by histopathologic examination. MDA and NO levels were significantly higher in the untreated group than in the treated group. Namely, trapidil treatment significantly decreased MDA and NO levels in the injured tissues, the levels of which are similar to those in the tissues of control animals. The grades of ulcer depth were significantly improved in the treated group. These results indicate that the reactive oxygen radicals increase in the early phase of corrosive esophagitis and cause tissue damage. We suggest that trapidil treatment may be useful in acute phase of corrosive esophageal injury. corrosive esophagitis; free oxgen radicals; trapidil; triazolopyrimidine © 2005 Tohoku University Medical PressInfants and young children often accidentally ingest corrosive substances. Ingestion of corrosive substance is a common health problem in the pediatric age group. Accidental ingestion of corrosive substances leads to serious upper aero digestive and esophageal injuries. Corrosive esophageal burns are the most common cause of esophageal stricture development (Haller et al.

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“…Therefore, preventing stricture formation is the main goal in most of the treatments. [6][7][8] Additionally, because stricture formation consists of fibrosis and inflammation during the wound healing process, medical treatments should also aim to reduce the inflammation. [9] Although many agents have been used in various studies to prevent the stricture development, antibiotics and steroids have only recently gained clinical approval.…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of garlic (Allium Sativum) oil inexperimental corrosive esophageal burns

Tanrıkulu

Tanrıkulu²,

Kılınç³

et al. 2016

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Corrosive esophageal burns, particularly common in developing countries, lead to different problems in different age groups. The ingestion of corrosive substances can cause such problems as stricture of the esophagus, to acute perforation, and even death. Because stricture formation is related to the severity of the initial injury, the prevention of stricture constitutes a main goal of treatment. The aim of this study was to investigate the protective and anti-inflammatory effects of garlic (Allium sativum) oil in corrosive esophageal burn.

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Effects of estradiol and progesterone on the synthesis of collagen in corrosive esophageal burns in rats

Cited by 53 publications

References 15 publications

The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study

The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study

Trapidil, an Inhibitor for Phosphodiesterase and Platelet-Derived-Growth Factor, Ameliorates Corrosive Esophageal Burn in Rats

Beneficial effects of garlic (Allium Sativum) oil inexperimental corrosive esophageal burns

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