Trapidil, an Inhibitor for Phosphodiesterase and Platelet-Derived-Growth Factor, Ameliorates Corrosive Esophageal Burn in Rats

Abstract

burn is a common health problem in the pediatric age group and causes serious esophageal injuries. The medical treatment in acute phase of corrosive esophageal injury is of particular importance for prevention of esophageal stricture. We therefore aimed to investigate the possible beneficial effect of trapidil (triazolopyrimidine), an inhibitor for phosphodiesterase and platelet-derived-growth-factor, during acute phase of esophageal corrosive injury. Wistar albino rats were randomly allocated to untreated, treated, and sham-operated groups (n = 10 for each group). Corrosive esophageal burn was generated with 10% NaOH solution. The rats were left untreated (untreated group) or treated with trapidil as a single dose of 40 mg/kg intraperitoneally after one hour of the injury (treated group). Abdominal esophageal segment was isolated and tied in sham-control group. The studied esophageal segment was removed from each animal after 24 hours. Malondialdehyde (MDA) and nitric oxide (NO) levels were measured in the esophageal tissues. The ulcer depth was graded by histopathologic examination. MDA and NO levels were significantly higher in the untreated group than in the treated group. Namely, trapidil treatment significantly decreased MDA and NO levels in the injured tissues, the levels of which are similar to those in the tissues of control animals. The grades of ulcer depth were significantly improved in the treated group. These results indicate that the reactive oxygen radicals increase in the early phase of corrosive esophagitis and cause tissue damage. We suggest that trapidil treatment may be useful in acute phase of corrosive esophageal injury. corrosive esophagitis; free oxgen radicals; trapidil; triazolopyrimidine © 2005 Tohoku University Medical PressInfants and young children often accidentally ingest corrosive substances. Ingestion of corrosive substance is a common health problem in the pediatric age group. Accidental ingestion of corrosive substances leads to serious upper aero digestive and esophageal injuries. Corrosive esophageal burns are the most common cause of esophageal stricture development (Haller et al.

Beneficial effects of garlic (Allium Sativum) oil inexperimental corrosive esophageal burns

“…The stricture formation occurs via collagen accumulation. [12,20] The main goal of any medical treatment is to reduce any inflammation because the severity of the acute inflammatory reaction plays the most significant role in stricture formation. [21] The current treatment protocols in corrosive esophagitis remain limited to antibiotics and steroids administration and neutralizations during the acute phase.…”

“…[9] To reduce inflammation and collagen synthesis and to prevent fibroplasia and stricture formation, many clinical and experimental studies have evaluated the medical efficiency of antioxidant and anti-inflammatory agents, such as sucralfate, palifermin, dimethyl sulfoxide, prednisolon, retinoic acid, zinc, trapidil, trimetazidine, and pentoxifylline. [9][10][11][12][13]20,21] Despite decreased stricture formations in these studies, the rate of stricture formation remained at 70%-100% in highgrade corrosive esophagitis. [9] Garlic oil, a diallyl trisulfide, is the main active constituent of garlic and is one of the oldest medicine.…”

“…[9] Although many agents have been used in various studies to prevent the stricture development, antibiotics and steroids have only recently gained clinical approval. [10][11][12][13] Garlic oil, a diallyl trisulfide, is the main active constituent of garlic. The beneficial effects of dietary garlic have been known for centuries.…”

Management of gastrostomy to prevent perforation in acute severe corrosive esophagitis and gastritis: An experimental study

“…Sodium hydroxide was the preferred corrosive agent because of its well-known effects as well as being the most commonly used corrosive agent in experimental studies (9,10).…”

Late Complications of Corrosive Esophagitis May Be Predicted Using Biochemical Methods: Preliminary Report

“…1,2 Patients usually present with nausea, vomiting, drooling, dysphagia or odynophagia, mucosal bleeding, and respiratory distress associated with aspiration. 3,4 Several diagnostic trials were conducted to identify esophageal injury in CE using radiocontrast esophagography, scintigraphy, and esophageal ultrasound; however, the usefulness and prognostic value of these methods remain controversial. 5,6 Currently, endoscopy, which is performed within 24-48 hours of ingestion, is recommended as the most effective diagnostic method for assessing the depth and extent of injury, and consequently the potential for complications.…”