Beneficial effects of garlic (Allium Sativum) oil inexperimental corrosive esophageal burns

Tanrıkulu, Ceren Şen; Tanrıkulu, Yusuf; Kılınç, Fahriye; Bahadir, Burak; Çan, Murat; Köktürk, Fürüzan

doi:10.5505/tjtes.2016.64509

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…As in these studies, many substances have been investigated in terms of their effects on the healing of corrosive esophagitis. Examples of these are methylene blue, polaprezinc, garlic (Allium sativum) oil, or platelet rich plasma [18][19][20][21] . The common aspect of all these substances is that they have anti-inflammatory and antioxidant effects.…”

Section: Discussionmentioning

confidence: 99%

The healing effect of resveratrol and platelet rich plasma in corrosive esophagitis model in rats

Özden

GÖMEÇ

Şahin

et al. 2022

CMJ

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Background: Corrosive esophageal burns have high morbidity and mortality. The effective treatment is controversial. In our study, we aimed to examine the effects of resveratrol (RSV) and platelet rich plasma (PRP) on healing in the corrosive esophagitis model in rats. Material and methods: A total of 24 rats were randomly divided into 4 groups each as esophagitis, control, PRP and RSV groups. No treatment was administered to the control group. The esophagitis model was induced in the esophagitis and treatment groups. The esophagitis group was not treated. PRP group was treated with PRP, RSV group was treated with RSV. Pathological and biochemical examinations were performed from distal esophagitis. Results: The highest tissue IL-1, IL-6, and TNF-α levels were observed in the esophagitis group. The lowest tissue IL-1, IL-6, and TNF-α levels were noted in the control group. The highest tissue TAS levels were observed in the control group. The lowest tissue TAS levels were noted in the esophagitis group. The other groups had significantly lower mean tissue TOS and OSI levels than the esophagitis group (P

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Section: Discussionmentioning

confidence: 99%

The healing effect of resveratrol and platelet rich plasma in corrosive esophagitis model in rats

Özden

GÖMEÇ

Şahin

et al. 2022

CMJ

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“…birçok ilaç ve maddenin yararları gösterilmiş olsa da bunlardan klinik uygulamaya geçen olmamıştır. 38,39 Kortikosteroidler inflamasyon, granülasyon ve fibröz doku gelişimini azaltabilmektedir. Bu nedenle bazı çalışmalarda, özofagus darlığı gelişimini engellemek üzere korozif hastalar da tedavide denenmiş ve özellikle yüksek doz steroid tedavisinin evre IIb özofagus yanıklarında steroid yan etkisi olmaksızın hasarı ve özofagus dilatasyonu gereksinimini azaltabileceği gösterilmiştir.…”

Section: Korozif Madde İçimi Yönetimiunclassified

Corrosive Substance Ingestion in Children: A Current Evaluation and Treatment Approach

Uygun¹

2018

Turkiye Klinikleri J Pediatr

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RESİM 1: Bazı açıkta satılan tehlikeli korozif maddeler (A-F). (A): su kaplarına konularak açıkta satılan sıvı korozif maddeler; (B, C): Mahalle pazarlarında (B) orijinal sirke ruhu (C1) ve hakiki Siirt sirkesi gibi isimlerle satılan ve turşu yapımında kanunen yasak olmasına karşın kullanılan asetik asit (C1 ve C2) normal pet şişe suyuna (C3) çok benzemektedir; (D): Sülfürik asit içeren çocuk korumalı kapaksız akü asidi (D1) ile akü için saf su (D2) yanyana satılmaktadır; (E): Korozifler gıdalar ile birlikte pet su şişesinde; E1: kireç çözücü; E2: çamaşır suyu; E3: deterjan, (F): Kostik etiketi ile merdiven altı üretilmiş güçlü alkali sodyum hidroksit içeren yağ çözücü.

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“…In their study comparing beta-aminopropionitrile (BAPN) and prednisolone, Aciksari et al [13] found that BAPN was able to decrease the development of stenosis and tissue damage better than prednisolone. Şen Tanrıkulu et al [29] found that garlic oil is an effective agent in promoting the regression of esophageal stenosis and tissue damage caused by corrosive burns. In another study, [23] investigators found that dimethyl sulfoxide may decrease the severity of tissue damage.…”

mentioning

confidence: 99%

The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study

Tanrıkulu

Kılınç

et al. 2018

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: In developing countries, esophageal burns are quite common. They are caused by the ingestion of corrosive substances that may lead to esophageal perforation in the short-term and stricture formation in the long-term. Prevention of stricture progression in the esophagus is the main aim of the treatment for corrosive esophageal burns. We aimed to investigate the protective and anti-inflammatory effects of methylene blue (MB) treatment on corrosive esophageal burns. METHODS: Twenty-eight rats were used in the study and randomly divided into four equal groups; group 1 (Sham), group 2 (control), group 3 (topical treatment), and group 4 (topical plus systemic treatment). Except for group 1 (Sham group), all three groups received sodium hydroxide (NaOH) in order to generate esophageal burns. In addition, group 2 was given normal saline, group 3 topical MB, and group 4 topical and systemic MB. RESULTS: Hydroxyproline levels were found to be lower in each of the treatment groups as compared to the control group (p=0.005 for group 3 and p=0.009 for group 4). There were no differences in the tumor necrosis factor-α (TNF-α) levels between the groups. The stenosis index (SI) in the treatment groups was also lower than the control group (p=0.016 for group 3 and p=0.015 group 4). The histopathologic damage score (HDS) was prominently lower in group 4 as compared to the control group (p=0.05). CONCLUSION: MB is effective in treating tissue damage caused by corrosive esophageal burns and in preventing esophageal stenosis. Complication rates of corrosive esophageal burns may be decreased by using MB in the initial treatment stage.

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Beneficial effects of garlic (Allium Sativum) oil inexperimental corrosive esophageal burns

Cited by 5 publications

References 25 publications

The healing effect of resveratrol and platelet rich plasma in corrosive esophagitis model in rats

The healing effect of resveratrol and platelet rich plasma in corrosive esophagitis model in rats

Corrosive Substance Ingestion in Children: A Current Evaluation and Treatment Approach

The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study

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