Effects of ESR1, FSHB and RBP4 genes on litter size in a Large White and a Landrace Herd

Wang, Aiguo; Fu, Jinlian; Lin, Haichao

doi:10.5194/aab-49-64-2006

Cited by 17 publications

(19 citation statements)

References 5 publications

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“…Zhao et al (1998) found a retroposon in intron 1 of FSH that non-retroposon homozygote sows produced 2.53 piglets more than retroposon homozygote sows for TNB on the 1 st parity. On the contrary, recent study reported inversely association between piglet number and HaeIII-FSH locus in Polish pig line (Korwin-Kossakowsak et al, 2003), in Large White (Wang et al, 2006;Humpolicek et al, 2007). Microsatellite 5'-flanking FSH affected number at weaning, litter weight at weaning, average individual weight at weaning in Large White x Chinese Meishan F 2 (Li et al 2008).…”

Section: Fsh Polymorphisms Discovery and Associationmentioning

confidence: 84%

Novel BsuRI-c.930A>G-FSHb Associated with Litter Size Traits on Large White X Landrace Crossbred Sows

Pripwai¹,

Mekchay²

2011

JAS

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The objective of this experiment was to identify the novel single nucleotide polymorphisms (SNPs) on porcine follicle stimulating hormone  subunit (FSH) genes. Moreover, their association with litter size traits in commercial pigs will be analyzed. 1,155 Large White x Landrace crossbred sows were bled and DNA was extracted. The records included total number of piglet born (TNB), number of piglet born alive (NBA), number of piglets stillbirth (SB) and number of piglets mummified (MM). The known sequence of porcine FSH (GenBank accession no. D00621.1) was screened homology to known sequences in term of express sequenced tags (ESTs) in public domain, GenBank. The primers were designed for amplified the novel BsuRI-c.930A>G-FSH fragment which confirmed by PCR-RFLP and nucleotide sequencing then genotyping. The favorable cut homozygous G/G allele was highly significant higher than A/G allele in terms of TNB and NBA. While, published marker HaeIII-g.5894A>G-FSH was not significant difference in any litter traits. For haplotype analysis, c.930A>G-g.5894A>G of FSHβ, unfavorable GG/AA haplotype was significantly lower TNB and NBA than other haplotypes. Conversely, this haplotype was significantly higher MM than others. The study concluded that BsuRI-c.930A>G and the haplotype of HaeIII-g.5894A>G -BsuRI-c.930A>G of FSH may used for marker-assisted selection on pig breeding program.

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Section: Fsh Polymorphisms Discovery and Associationmentioning

confidence: 84%

Novel BsuRI-c.930A>G-FSHb Associated with Litter Size Traits on Large White X Landrace Crossbred Sows

Pripwai¹,

Mekchay²

2011

JAS

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“…One marker, which is used in commercial pig production, is the estrogen receptor gene 1 (ESR1), and ROTHSCHILD et al (1996) were the first who observed an association between ESR1 genotypes and litter size in swine. However, so far, there are a lot of inconsistent studies with regard to influence on the ESR1 gene on fecundity parameters in swine (SHORT et al, 1997;DEPUYDT et al, 1999;DRÖGEMÜLLER et al, 1999;KMIEĆ et al, 2002;GIBSON et al, 2002; VAN RENS and VAN DER LENDE, 2002;MATOUŠEK et al, 2003;GOLIÁŠOVÁ and WOLF, 2004;HORÁK et al, 2005;HOROGH et al, 2005;WANG et al, 2006). Therefore, additional candidate genes with potential influence on litter size are studied.…”

Section: Introductionmentioning

confidence: 99%

Analysis of association of GPX5, FUT1 and ESR2 genotypes with litter size in a commercial pig cross population

et al. 2006

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The aim of this study was to investigate, if special genotypes of the genes glutathione peroxidase 5 (GPX5), fucosyltransferase 1 (FUT1) and estrogen receptor 2 (ESR2) are associated with litter size in a commercial pig cross population. For this purpose, a total of 123 F 2 sows were divided into two extreme performance groups, one with a high litter size (n = 61, ≥ 14.3 piglets per litter) and one with a low litter size (n = 62, ≤ 11.3 piglets per litter) and genotyped using PCR-RFLP methods. The Chi-square test was used in order to investigate, if a special genotype occurs significantly more often in one of the two performance groups (p < 0.05). Whereas no association was found between different ESR2 or GPX5 genotypes with one of the two performance groups, the number of sows with AB genotypes at the FUT1 gene was significantly increased in the high performance group in comparison to the low performance group.

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“…of pigs bred in the USA, Europe and Asia (Drögemüller et al 2001;Kmieć et al 2002;Terman et al 2006;Wang et al 2006;Wu et al 2006). The breeding potential of gilts is determined by many factors and fully reveals itself after reaching sexual maturity and giving birth to the first and further litters.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of ESR, FSHß, RBP4, PRL, OPN genes and their influence on morphometric traits of gilt reproductive tract before sexual maturity

et al. 2013

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The aim of the study was to examine the effect of gene polymorphism on the development of the reproductive system in 100 Polish Large White and 100 Polish Landrace gilts. Gilts were slaughtered when they reached 100 kg, and their uterus weight and length, as well as the ovary weight and volume were evaluated. Differences between gilts of both breeds were observed in some traits of the reproductive system, such as the uterine weight without the broad ligament (P ≤ 0.05) and the uterine capacity (P ≤ 0.01). Polish Landrace gilts were characterized with higher uterine weight and higher uterine capacity; they were also younger at the time of slaughter (P ≤ 0.05). No BB homozygote relative to the oestrogen receptor gene was found in the examined populations of Polish Landrace gilts. Also, a very low number of gilts with the AA genotype relative to follicle stimulating hormone gene was observed in both populations. Polymorphism of the examined genes had an effect on numerous traits which define the size of particular uterine sections, and thus it influenced the development of potential fertility of gilts before they entered the reproductive cycle. Based on our results we can conclude that genetic determination of reproductive potential occurs already in prepubertal gilts. The results may be used for the prognosis of fertility potential in gilts.

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Effects of ESR1, FSHB and RBP4 genes on litter size in a Large White and a Landrace Herd

Cited by 17 publications

References 5 publications

Novel BsuRI-c.930A>G-FSHb Associated with Litter Size Traits on Large White X Landrace Crossbred Sows

Novel BsuRI-c.930A>G-FSHb Associated with Litter Size Traits on Large White X Landrace Crossbred Sows

Analysis of association of GPX5, FUT1 and ESR2 genotypes with litter size in a commercial pig cross population

Polymorphism of ESR, FSHß, RBP4, PRL, OPN genes and their influence on morphometric traits of gilt reproductive tract before sexual maturity

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