Effects of early postnatal sibling deprivation on anxiety and vulnerability to cocaine in offspring rats

Li, Yan Qin; Wang, Xiao Yi; Zhai, Hai Feng; Zheng, Yongchang; Zhang, Xiang Yang; Kosten, Therese A.; Lü, Lin

doi:10.1007/s00213-008-1169-9

Cited by 14 publications

(18 citation statements)

References 53 publications

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“…The behavioural locomotor activity test was based on our and others' previous studies (Boudreau and Wolf, 2005;Li et al, 2008b). Briefly, rats were habituated to the behavioural testing procedure by being placed in photocell cages for at least 1 h. They then received an injection of drug/vehicle and were immediately placed in the chambers.…”

Section: Locomotor Activitymentioning

confidence: 99%

Rapamycin prevents drug seeking via disrupting reconsolidation of reward memory in rats

Lin

Liu

Wen

et al. 2013

Int. J. Neuropsychopharm.

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The maladaptive drug memory developed between the drug-rewarding effect and environmental cues contributes to difficulty in preventing drug relapse. Established reward memories can be disrupted by pharmacologic interventions following their reactivation. Rapamycin, an inhibitor of mammalian target of rapamycin (mTOR) kinase, has been proved to be involved in various memory consolidation. However, it is less well characterized in drug memory reconsolidation. Using a conditioned place preference (CPP) procedure, we examined the effects of systemically administered rapamycin on reconsolidation of drug memory in rats. We found that systemically administered rapamycin (0.1 or 10 mg/kg, i.p.) after re-exposure to drug-paired environment, dose dependently decreased the expression of CPP 1 d later, and the effect lasted for up to 14 d and could not be reversed by a priming injection of morphine. The effect of rapamycin on morphine-associated memory was specific to drug-paired context, and rapamycin had no effect on subsequent CPP expression when rats were exposed to saline-paired context or homecage. These results indicated that systemic administration of rapamycin after memory reactivation can persistently inhibit the drug seeking behaviour via disruption of morphine memory reconsolidation in rats. Additionally, the effect of rapamycin on memory reconsolidation was reproduced in cocaine CPP and alcohol CPP. Furthermore, rapamycin did not induce conditioned place aversion and had no effect on locomotor activity and anxiety behaviour. These findings suggest that rapamycin could erase the acquired drug CPP in rats, and that mTOR activity plays an important role in drug reconsolidation and is required for drug relapse.

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Section: Locomotor Activitymentioning

confidence: 99%

Rapamycin prevents drug seeking via disrupting reconsolidation of reward memory in rats

Lin

Liu

Wen

et al. 2013

Int. J. Neuropsychopharm.

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“…Neonatal sibling deprivation during the first 2-3 weeks of life attenuates the locomotor and rewarding effects of cocaine in male rats relative to controls reared in a litter of four males and four females (Li et al, 2008). Although no differences were reported in females, only one conditioning regimen was examined, and thus it is possible that sensitivity of females to stimulants may be affected under different conditioning parameters.…”

Section: B Social Influencesmentioning

confidence: 99%

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

2013

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“…As described in previous studies [14,15] , 25 squares (20.0 cm×20.0 cm) were delineated on the floor, and the number of times the rats crossed between squares was counted by two observers (blind to the experimental groups) over a 10-min period. Crossing, as a measure of locomotion, was counted when the rat moved all four legs from one quadrant to another.…”

Section: Abdominal Withdrawal Reflex (Awr)mentioning

confidence: 99%

“…To test the effect of Chang'an II on depression, the two-bottle sucrose intake test was performed as described in a previous study [14] . Rats were housed singly over the test.…”

Section: Two-bottle Sucrose Intake Testmentioning

confidence: 99%

Herbal prescription Chang'an II repairs intestinal mucosal barrier in rats with post-inflammation irritable bowel syndrome

Wang

Zheng

et al. 2015

Acta Pharmacol Sin

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Aim: The herbal prescription Chang'an II is derived from a classical TCM formula Tong-Xie-Yao-Fang for the treatment of liver-qi stagnation and spleen deficiency syndrome of irritable bowel syndrome (IBS). In this study we investigated the effects of Chang'an II on the intestinal mucosal immune barrier in a rat post-inflammation IBS (PI-IBS) model. Methods: A rat model of PI-IBS was established using a multi-stimulation paradigm including early postnatal sibling deprivation, bondage and intrarectal administration of TNBS. Four weeks after TNBS administration, the rats were treated with Chang'an II (2.85, 5.71 and 11.42 g·kg -1 ·d -1 , ig) for 14 d. Intestinal sensitivity was assessed based on the abdominal withdrawal reflex (AWR) scores and fecal water content. Open field test and two-bottle sucrose intake test were used to evaluate the behavioral changes. CD4 + and CD8 + cells were counted and IL-1β and IL-4 levels were measured in intestinal mucosa. Transmission electron microscopy was used to evaluate ultrastructural changes of the intestinal mucosal barrier. Results: PI-IBS model rats showed significantly increased AWR reactivity and fecal water content, and decreased locomotor activity and sucrose intake. Chang'an II treatment not only reduced AWR reactivity and fecal water content, but also suppressed the anxiety and depressive behaviors. Ultrastructural study revealed that the gut mucosal barrier function was severely damaged in PI-IBS model rats, whereas Chang'an II treatment relieved intestinal mucosal inflammation and repaired the gut mucosal barrier. Furthermore, PI-IBS model rats showed a significantly reduced CD4 + /CD8 + cell ratio in lamina propria and submucosa, and increased IL-1β and reduced IL-4 expression in intestinal mucosa, whereas Chang'an II treatment reversed PI-IBS-induced changes in CD4 + /CD8 + cell ratio and expression of IL-1β and IL-4. Conclusion: Chang'an II treatment protects the intestinal mucosa against PI-IBS through anti-inflammatory, immunomodulatory and anti-anxiety effects.

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Effects of early postnatal sibling deprivation on anxiety and vulnerability to cocaine in offspring rats

Cited by 14 publications

References 53 publications

Rapamycin prevents drug seeking via disrupting reconsolidation of reward memory in rats

Rapamycin prevents drug seeking via disrupting reconsolidation of reward memory in rats

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

Herbal prescription Chang'an II repairs intestinal mucosal barrier in rats with post-inflammation irritable bowel syndrome

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