Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

Bardo, Michael T.; Neisewander, Janet L.; Kelly, Thomas C.

doi:10.1124/pr.111.005124

Cited by 142 publications

(111 citation statements)

References 513 publications

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“…The neurobiological mechanisms responsible for the effects of social learning on drug selfadministration are not known, but candidate systems are those that process information regarding both drug and social stimuli (see reviews by Bardo et al, 2013;Burkett and Young, 2012;McGregor and Bowen, 2012). For instance, the amygdaloid complex plays a critical role in the assimilation of interoceptive (i.e., drug effects) and exteroceptive (i.e., social environment) stimuli and may serve as a locus of integration for drug and social reinforcement (Badiani, 2013).…”

Section: Discussionmentioning

confidence: 99%

The effects of social learning on the acquisition of cocaine self-administration

Smith

Lacy

Strickland

2015

Drug and Alcohol Dependence

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Background-Social learning models of substance use propose that drug-use behaviors are learned by observing and mimicking the behavior of others. The aim of this study was to examine the acquisition of cocaine self-administration in three groups of experimentally naïve rats: rats that were tested in isolation, rats that were tested in the presence of another rat that had access to cocaine and had previously been trained to self-administer cocaine, and rats that were tested in the presence of another rat that did not have access to cocaine.Methods-Male rats were reared in isolated or pair-housed conditions and implanted with intravenous catheters. Pair-housed rats were then assigned to drug-experienced or drug-naïve conditions. In the drug-experienced condition, one rat of each pair was trained to self-administer cocaine in isolation before the reintroduction of its partner. In the drug-naïve condition, one rat of each pair did not have access to cocaine for the duration of the study. For each group, the acquisition of cocaine self-administration was measured over 15 days in rats with access to cocaine but no prior operant training.Results-Rats tested with a drug-experienced partner were faster to acquire cocaine selfadministration and emitted more active lever presses than rats tested with a cocaine-naïve partner. Data for the isolated control group fell between the other two groups on these measures.Conclusion-These data indicate that the acquisition of cocaine self-administration can either be facilitated or inhibited by social contact. Collectively, these results support a social-learning model of substance use.

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Section: Discussionmentioning

confidence: 99%

The effects of social learning on the acquisition of cocaine self-administration

Smith

Lacy

Strickland

2015

Drug and Alcohol Dependence

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“…Recently, a fierce debate on this point has been reported in the literature (Diana, 2011;Levy, 2013). Without minimizing the obvious role of the degree, amount, and duration of drug exposure and the roles of genetics (Crabbe, Phillips, & Belknap, 2010;Moeller et al, 2013), environmental/developmental factors (Bardo, Neisewander, & Kelly, 2013;Doremus-Fitwater, Varlinskaya, & Spear, 2010), and Bgene-to-environmentî nteractions (Cabib, Orsini, Le Moal, & Piazza, 2000;Caspi & Moffitt, 2006), most recent frameworks basically suggest that individual vulnerabilities to substances of abuse may also be related to underlying neuro biological factors (George, Koob, & Vendruscolo, 2014;Piazza & Deroche-Gamonet, 2013;Volkow, Wang, Fowler, & Tomasi, 2012; for a critical debate, see also the comments in Psychopharmacology, 231(19), 2014). Although the distinction between nonpathological and pathological drug users based on behavioral symptoms is a matter of debate, anecdotal and scientific reports agree on the idea that drug use does not necessarily result in drug abuse and drug dependence; rather it has been hypothesized that drug use is on a continuum that can lead to drug addiction (Koob et al, 2004).…”

Section: Motor Cognition In Asd: Motor Anomalies Impacting On Social mentioning

confidence: 99%

The motor way: Clinical implications of understanding and shaping actions with the motor system in autism and drug addiction

Casartelli

Chiamulera

2015

Cogn Affect Behav Neurosci

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To understand others' minds is crucial for survival; however, it is quite puzzling how access to others' minds can be-to some extent-direct and not necessarily mediated by conceptual reasoning. Recent advances in neuroscience have led to hypothesize a role for motor circuits not only in controlling the elementary physical features of movement (e.g., force, direction, and amplitude), but also in understanding and shaping human behavior. The concept of Bmotor cognition^refers to these aspects, and neurophysiological, neuroimaging, and behavioral studies in human and nonhuman primates support this view. From a clinical perspective, motor cognition represents a challenge in several domains. A thorough investigation of the neural mechanisms mediating motor action/intention understanding and automatized/compulsive behaviors seems to be a promising way to tackle a range of neurodevelopmental and drug-related disorders. On the one hand, anomalies in motor cognition may have cascade effects on social functioning in individuals with autism spectrum disorder (ASD); on the other, motor cognition may help explain the pathophysiology of drug-seeking and drug-taking behaviors in the most severe phase of drug addiction (i.e., see drug dependence, motor low-order cue reactivity). This may represent a promising approach that could improve the efficacy of rehabilitative interventions. The only way to shed light on multifactorial disorders such as ASD and drug addiction is through the investigation of their multiple factors. This motor way can promote new theoretical and experimental perspectives that would help bridge the gap between the basic neuroscience approach and clinical practice.

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“…Little is known about the effects of environmental variables on specific D2-like receptor subtypes; it may be that the environmental variables associates with the social hierarchy differentially affect D 2 , D 3 , and D 4 receptors. Considering the well-documented ability of environmentally derived stress and enrichment to modulate cocaine self-administration (see, eg, Nader et al, 2012a;Bardo et al, 2013) the effects of environmental variables on D 3 and D 4 receptors warrant further study.…”

Section: Influence Of Social Rank On the Effects Of Buspironementioning

confidence: 99%

Effects of Oral and Intravenous Administration of Buspirone on Food–Cocaine Choice in Socially Housed Male Cynomolgus Monkeys

Czoty

Nader

2014

Neuropsychopharmacol

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Drugs acting at D 3 dopamine receptors have been suggested as medications for cocaine dependence. These experiments examined the effects of intravenously and orally administered buspirone, a D2-like receptor antagonist with high affinity for D 3 and D 4 receptors, on the relative reinforcing strength of cocaine in group-housed male cynomolgus monkeys. Use of socially housed monkeys permitted the assessment of whether social status, known to influence D2-like receptor availability, modulates the behavioral effects of buspirone. Buspirone was administered acutely to monkeys self-administering cocaine under a food-drug choice procedure in which a cocaine self-administration dose-effect curve was determined daily. When administered by either route, buspirone significantly decreased cocaine choice in dominant-ranked monkeys. In subordinate monkeys, however, i.v. buspirone was ineffective on average, and oral buspirone increased choice of lower cocaine doses. The effects of buspirone only differed according to route of administration in subordinate monkeys. Moreover, it is noteworthy that the effects of buspirone were similar to those of the D 3 receptor-selective antagonist PG01037 and qualitatively different than those of less selective drugs that act at D2-like or serotonin (5-HT) 1A receptors, suggesting a D 3 and possibly D 4 receptor mechanism of action for buspirone. Taken together, the data support the utility of drugs targeting D 3 /D 4 receptors as potential treatments for cocaine addiction, particularly in combination with enriching environmental manipulations.

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Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

Cited by 142 publications

References 513 publications

The effects of social learning on the acquisition of cocaine self-administration

The effects of social learning on the acquisition of cocaine self-administration

The motor way: Clinical implications of understanding and shaping actions with the motor system in autism and drug addiction

Effects of Oral and Intravenous Administration of Buspirone on Food–Cocaine Choice in Socially Housed Male Cynomolgus Monkeys

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