Effects of dietary supplementation with itaconic acid on the growth performance, nutrient digestibility, slaughter variables, blood biochemical parameters, and intestinal morphology of broiler chickens

Zhu, Xin; Zhang, Yinhang; Zhao, Yingzhuo; Tao, Lijuan; Liu, Haiying; Dong, Weiguo; Yang, Guiqin; Li, Lin

doi:10.1016/j.psj.2022.101732

Cited by 17 publications

(13 citation statements)

References 42 publications

(45 reference statements)

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“…When cells are subjected to various factors, such as stress stimulation and damage, cell membrane permeability increases, alkaline phosphatase is released into the blood speed increase and there is a significant rise in serum ALP activity [ 25 ]. In this study, the oregano oil combined with macleaya cordata oral solution significantly improved serum biochemical indices, which is consistent with the effect of the extracts of oregano oil or macleaya cordata previously reported [ 23 , 26 ].…”

Section: Discussionsupporting

confidence: 92%

Oregano Oil Combined with Macleaya Cordata Oral Solution Improves the Growth Performance and Immune Response of Broilers

Zhang

Chen

et al. 2022

Animals

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The abuse of AGPs in animal husbandry has led to severe problems such as drug resistance and ecological, and environmental destruction, which seriously threaten human health and public health security. In recent years, extracts of oregano oil and macleaya cordata have become a hot spot in the research and application of AGP substitutes for their safety and high efficiency. This study is the first to report the effect of oregano oil combined with macleaya cordata oral solution on broiler growth performance. A total of 960 one-day-old broiler chickens were randomly divided into four treatment groups (240 chickens per group). Each treatment group was divided into six replicate groups (40 birds per replicate group). There were four groups in this study: the solvent control group, the oregano essential oil combined with macleaya cordata extract oral solution group (OS group), the oregano essential oil oral solution group (OEO group), and the macleaya cordata extract oral solution group (MCE group). Two chickens from each replicate group were collected and mixed into a composite sample. Six composite samples were obtained for each treatment group. The results showed that the oregano oil combined with macleaya cordata oral solution significantly improved the growth performance of broiler chickens. At the same time, serum biochemical indices, serum antioxidant indices, serum immune indices, serum cytokines, and intestinal morphology were significantly improved by the OS group. This study shows that oregano oil combined with macleaya cordata oral solution has substantial potential to be an alternative to AGPs for broilers.

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Section: Discussionsupporting

confidence: 92%

Oregano Oil Combined with Macleaya Cordata Oral Solution Improves the Growth Performance and Immune Response of Broilers

Zhang

Chen

et al. 2022

Animals

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“…The crypt depth is the main indicator reflecting the development and maturation rate of intestinal epithelial cells. The lower crypt depth is favored, which can reduce the intestinal epithelial cell turnover rate and save energy ( Lin and Lee, 2021 ; Zhu et al, 2022 ). The higher the VH/CD ratio, the stronger the intestinal absorption capacity ( Du and Guo, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Supplemental enzymes and probiotics on the gut health of broilers fed with a newly harvested corn diet

Luo¹,

Wang²,

Yuan³

2023

Poultry Science

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“…However, it was not reported whether the diminished weight gain was due to a general growth inhibition or a preferential effect on fat accumulation. The potential impact of itaconate on organismal redox balance was recently addressed in a study on itaconate supplementation of chicken feed [ 21 ]. These authors showed that adding up to 1% of itaconate to feed had several desirable effects of economic importance, including higher breast and thigh muscle yield, but also led to positive changes in objective biomarkers of amino acid synthesis and antioxidative responses.…”

Section: Discussionmentioning

confidence: 99%

Itaconate Isomers in Bread

et al. 2022

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The naturally occurring isomers itaconate, mesaconate and citraconate possess immunomodulatory, antioxidative and antimicrobial properties. However, it is not known whether they occur in commonly consumed human foods. Considering that they can arise as a result of heat conversion, we tested whether they occur in bread, representing a commonly consumed baked good. Using high-performance liquid chromatography–tandem mass spectrometry, we measured concentrations of the three isomers and their potential precursors, citrate and cis-aconitate, in unbaked sourdough, and dough, and in crumb and crust of baked bread. All three isomers were detected at low concentrations (<20 pmol/mg dry weight) in sourdough, dough, crumb and crust. Concentrations of itaconate and citraconate were substantially higher in crust than in crumb of wheat and rye bread, and a modest increase in mesaconate was observed in crust of rye bread. In contrast, cis-aconitate concentrations were considerably lower in crust, which was consistent with the conversion of cis-aconitate to itaconate isomers due to higher temperature of the dough surface during baking. Based on data on the average consumption of bread and related baked goods in Germany, the daily intake of itaconate isomers was estimated to be roughly 7–20 µg. Thus, baked goods constitute a regular dietary source of low amounts of itaconate isomers. In order to enable studies on the impact of dietary intake of itaconate isomers on human health, their concentrations should be assessed in other foods that are subjected to high heating.

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Effects of dietary supplementation with itaconic acid on the growth performance, nutrient digestibility, slaughter variables, blood biochemical parameters, and intestinal morphology of broiler chickens

Cited by 17 publications

References 42 publications

Oregano Oil Combined with Macleaya Cordata Oral Solution Improves the Growth Performance and Immune Response of Broilers

Oregano Oil Combined with Macleaya Cordata Oral Solution Improves the Growth Performance and Immune Response of Broilers

Supplemental enzymes and probiotics on the gut health of broilers fed with a newly harvested corn diet

Itaconate Isomers in Bread

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