Effects of Dietary Nucleotides on Immune Mechanisms and Physical State in Children with Chronic Respiratory Problems

Abstract

Heavy industrial pollution and/or passive smoking negatively affect the overall immune health of a population. We used a model of children with chronic respiratory problems and evaluated the effects of short term supplementation of their diet with nucleotides. We measured the level of sIgA, eNO levels and total physical activity. We found positive effects of oral supplementation with commercially available nucleotides. Our data demonstrate strong improvements in physical activity, strong decrease of eNO levels and maintaining of the levels of sIgA. We conclude that supplementation with nucleotides offers an easy way to improve health conditions in children.

Glucan Supplementation Regulates Secretory Immunity and Stress

“…A large study using dogs showed regulation of general as well as antigen specific IgA and IgM reactions (Stuyven et al, 2010). Lehne et al (2006) confirmed findings of positive effects of glucan supplementation on improvements of immune reactions (Richter et al, 2015a;2015b;2015c). It is clear that insoluble dietary fiber playsan important role in the regulation of both immune reactions and psychological state.…”

Effects of dietary Bacillus coagulans and yeast hydrolysate supplementation on growth performance, immune response and intestinal barrier function in weaned piglets

“…Nucleotide, a crucially bioactive constituent of YH, served as the basic unit of nucleic acids and modulated most biochemical processes (Gil et al, 2007). The exogenous supply of nucleotides was demanded for maintaining the normal function of cells under the stressful conditions, such as nutrient restriction, immune challenge and the rapid growth of tissues (e.g., intestine and liver; Josef et al, 2015;Beom et al, 2019).…”