A Short History of Imuregen - An Original Tissue Extract

Kubelková, Klára; Macela, Aleš

doi:10.31482/mmsl.2019.008

Cited by 4 publications

(4 citation statements)

References 2 publications

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“…Juvenil is a nontoxic alcohol-ether extract of bovine tissue registered as a dietary supplement with modulatory activity on the immunity, dominantly on cells of the innate immune system, and on the organism's regeneration [25,26]. Juvenil is a complex mixture of peptides, nucleotides, free amino acids, and some other components of animal origin [27].…”

Section: Juvenil and Placebomentioning

confidence: 99%

Modulation of Gut Microbiome and Autism Symptoms of ASD Children Supplemented with Biological Response Modifier: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study

Hrnciarova,

Kubelkova,

Bostik

et al. 2024

Nutrients

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The etiology and mechanisms of autism and autism spectrum disorder (ASD) are not yet fully understood. There is currently no treatment for ASD for providing significant improvement in core symptoms. Recent studies suggest, however, that ASD is associated with gut dysbiosis, indicating that modulation of gut microbiota in children with ASD may thus reduce the manifestation of ASD symptoms. The aim of this pilot study (prospective randomized, double-blinded, placebo-controlled) was to evaluate efficacy of the biological response modifier Juvenil in modulating the microbiome of children with ASD and, in particular, whether Juvenil is able to alleviate the symptoms of ASD. In total, 20 children with ASD and 12 neurotypical children were included in our study. Supplementation of ASD children lasted for three months. To confirm Juvenil’s impact on the gut microbiome, stool samples were collected from all children and the microbiome’s composition was analyzed. This pilot study demonstrated that the gut microbiome of ASD children differed significantly from that of healthy controls and was converted by Juvenil supplementation toward a more neurotypical microbiome that positively modulated children’s autism symptoms.

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Section: Juvenil and Placebomentioning

confidence: 99%

Modulation of Gut Microbiome and Autism Symptoms of ASD Children Supplemented with Biological Response Modifier: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study

Hrnciarova,

Kubelkova,

Bostik

et al. 2024

Nutrients

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“…The original technology for the preparation of Retisin was reused for production of bovine blood extract under the copyright name Juvenil. The Juvenil is also the basis for products under the brand name Imuregen (23).…”

Section: In Pressmentioning

confidence: 99%

Juvenil, a Natural Immune Booster Affecting Biological Responses Through Modulation Of gut Microbiota Composition

Bostik,

Kubelková,

Macela

2023

Mil. Med. Sci. Lett.

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Juvenil, a nontoxic extract of bovine blood, is registered as a dietary supplement having no side effects. It contains a broad spectrum of free amino acids, as well as small proteins and oligopeptides (molecular weights up to 10 kDa), various nucleotides, and small amounts of phospholipids. The complex of these exclusively natural components has been shown to support physiological responses of supplemented organisms.Juvenil has been studied for several decades using a wide range of both experimental and clinical studies.Analyses have shown that it acts directly neither on individual functional systems of the body nor on individual metabolic processes. Current findings indicate that modulatory effects of Juvenil occur through modulation of gut microbiota composition, which is associated with the modulation of microbiota-gut-brain axis signaling. In murine model that modulatory effect is reflected in the expression of an early activation c-Fos marker in specific parts of the brain.In this review we present a set of findings about Juvenil, which has a wide range of positive effects on the functional systems of organisms. These effects can be used to strenghten the resistance, immunity, and regeneration of human beings. According to its effects Juvenil can be classified as a psychobiotics.

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“…Inasmuch as the modern lifestyle is a test of the body's resistance, there may be a place for the use of nutritional supplements positively affecting human immunity or supporting full regeneration. Extracts from animal tissues sold as Retisin, Lyastin, Sangitin, and Silexil, as well as a number of extracts of plant origin, were prepared in the middle of the 20 th century in the former Czechoslovakia (2). One of these was an alcohol-ether extract from bovine tissues that was broadly tested to standardize its production, as well as for harmlessness, microbial contamination, and biological activity in model animal systems and on human volunteers.…”

Section: Introductionmentioning

confidence: 99%

Molecular Characterization of Alcohol-Ether Extract From Bovine Tissue

Kubelková¹,

Hubálek²,

Řehulka³

et al. 2021

Mil. Med. Sci. Lett.

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It is usual for information to be unavailable regarding the molecular composition of extracts from herbs or animal tissues that are popular in folk medicine. Here, we present analysis of the alcohol-ether extract from bovine tissue analogous to the basic substance used in such commercial products as Retisin, Imuregen, Actovegin, and Solcoseryl. The tested extract contains a whole spectrum of free amino acids, small proteins and oligopeptides of molecular weight up to 10 kDa, various nucleotides, and a small amount of phospholipids. Among the molecules that can explain some biological activities of the extract were identified those of taurine (2-aminoethanesulfonic acid, a derivative of the amino acid cysteine), several defensins, and bactericidal hemoglobin fragments known as hemocidins. All those molecules identified are natural components of bovine tissues, and a substantial number of them might be biologically active in vivo. Others are sources of readily available nutrients.

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A Short History of Imuregen - An Original Tissue Extract

Cited by 4 publications

References 2 publications

Modulation of Gut Microbiome and Autism Symptoms of ASD Children Supplemented with Biological Response Modifier: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study

Modulation of Gut Microbiome and Autism Symptoms of ASD Children Supplemented with Biological Response Modifier: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study

Juvenil, a Natural Immune Booster Affecting Biological Responses Through Modulation Of gut Microbiota Composition

Molecular Characterization of Alcohol-Ether Extract From Bovine Tissue

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