Effects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-α, PPAR-γ, and LPL mRNA expressions

Park, Mi-Young; Lee, Kwang-Seung; Sung, Mi‐Kyung

doi:10.1016/j.lfs.2005.05.043

Cited by 106 publications

(75 citation statements)

References 40 publications

(39 reference statements)

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“…PPARγ is a key nuclear receptor transcription factor in adipogenesis and lipogenesis (18) and plays an important role in liver lipid storage and the differentiation of fat cells (19,20). The findings in the present study indicated that both the 10% RMR-LM group and 20% RMR-LM group had significant ( * P<0.05) down-regulation of PPARγ mRNA expression in the liver.…”

Section: Discussionsupporting

confidence: 50%

Anti-obesity effect of robusta fermented with Leuconostoc mesenteroides in high-fat diet-induced obese mice

Choi

Ryu

Park

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Robusta beans cultivated with Monascus ruber (RMR) were successively fermented with Leuconostoc mesenteroides (LM) and the antiobesity effects were examined. To produce an obese mouse model to investigate the hypolipidemic effects, ICR mice were fed the same high-fat diet for 6 weeks. Treatment groups were given 10 or 20% RMR-LM. Body weight changes in the 20% RMR-LM group were lower compared with those in the control group. Visceral adipose tissue weight and adipose size were significantly lower in the 20% RMR-LM group compared with those in the control group. Significant improvement in glucose tolerance was observed in the 10 and 20% RMR-LM groups compared with the control group. The 20% RMR-LM group exhibited a significant reduction in serum glucose concentration. Hepatic mRNA levels of sterol regulatory element-binding protein 1, fas cell surface death receptor, and peroxisome proliferator-activated receptor γ, which are associated with lipid, and fatty acid metabolism, in the 20% RMR-LM group were significantly lower compared with those in the control group. The results of the present study demonstrated that 20% RMR-LM may be used to prevent obesity, and ameliorate diabetes and lipid metabolism imbalances.

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Section: Discussionsupporting

confidence: 50%

Anti-obesity effect of robusta fermented with Leuconostoc mesenteroides in high-fat diet-induced obese mice

Choi

Ryu

Park

et al. 2017

Experimental and Therapeutic Medicine

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“…And, it has been variable effects on expression and activity of PPARc. Some studies have reported that ginseng increases the PPARc mRNA expression in adipose tissue (Park et al 2005;Mollah et al 2009) and in some studies, it decreases. For instance, ginsenoside Rb1, Rg1, Rg3 and Rh2 decreased the lipid accumulation and PPARc mRNA expression levels in 3T3-L1 adipocytes (Hwang et al 2007;Park et al 2008;Hwang et al 2009), and ginsenoside Rh2 and Rg3 have been reported as an antagonist for PPARc (Hwang et al 2007;Hwang et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

et al. 2010

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The present study examined the antiobesity effect and mechanism of action of Korean white ginseng extracts (KGE) using high-fat diet (HFD)-induced obese mice. Mice were fed a low-fat diet (LFD), HFD or HFD containing 0.8 and 1.6% (w/ w) KGE diet (HFD ? 0.8KGE and HFD ? 1.6KGE) for 8 weeks. We also examined the effects of KGE on plasma triglyceride (TG) elevation in mice administrated with oral lipid emulsion. Body weight gain and white adipose tissue (WAT) weight were significantly decreased in the HFD ? 1.6KGE group, compared with the HFD group. The plasma TG levels were also significantly reduced in both HFD ? 0.8KGE and HFD ? 1.6KGE groups, while leptin levels were significantly decreased in only the HFD ? 1.6KGE group, compared with the HFD group. The HFD ? 1.6KGE group showed significantly lower mRNA levels of lipogenesis-related genes, including peroxisome proliferator-activated receptorc2 (PPARc2), sterol regulatory element binding protein-1c (SREBP-1c), lipoprotein lipase (LPL), fatty acid synthase (FAS) and diacylglycerol acyltransferase 1 (DGAT1), compared with the HFD group. In addition, a dose of 1000 mg/kg KGE inhibited the elevation of plasma TG levels compared with mice given the lipid emulsion alone. These results suggest that the anti-obesity effects of KGE may be elicited by regulating expression of lipogenesis-related genes in WAT and by delaying intestinal fat absorption.

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“…PPARγ has high expression in adipocytes and plays an important role in liver lipid storage and differentiation of fat cells. Lee et al have earlier suggested that PPARγ ligand upregulated the expression of genes involved in glucose uptake and lipid storage of adipocytes as well as lipid uptake and storage of the liver [39]. GLUT4 plays an explicit role in regulation of glucose homeostasis through translocation and activation, subsequently triggered by the insulin dependent phosphatidylinositol 3-kinase (PI3K)/phosphorylated protein kinase B (p-Akt) pathway [40,41].…”

Section: Discussionmentioning

confidence: 99%

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

Yin

Liu

Zhang

2017

Food & Nutrition Research

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This experiment, based on the previous study on R. mori, introduces whole mulberry branch powder into the diet to treat diabetic mice. Mulberry branch bark powder (MBBP) was administered orally to streptozotocin (STZ)-induced type II diabetic (T2D) mice to investigate hypoglycemic effects. After a 4-week period of diet consumption containing 5%, 10% and 20% MBBP, the fasting blood glucose, body weight and the related western blotting were measured, pathologic and immunohistochemical were observed. The 20% MBBP group showed a significant reduction in hyperglycemia and hyperinsulinemia; fasting blood glucose and insulin decreased from 25.0 to 14.8 mmol/L and 26.5 to 16.0 mU/L, respectively. Pathologic and immunohistochemical observation showed that MBBP administration lead to the repair of pancreas cells and restoration of insulin secretion. Dietary MBBP was associated with the decrease in the contents of 3, 4-methylenedioxeamphetamine, 8-OHdG, aspartate aminotransferase, and alanine aminotransferase, and the increase in antioxidative ability and glucose tolerance. Western blotting (WB) analysis suggested that MBBP decreased the TNF-α levels, thus relieving inflammation and improving liver function. It also led to the downregulation of apoptosis factor expression. WB also confirmed that MBBP enhanced the gene expression of the key enzymes: insulin receptor, insulin receptor substrate, p-AKT, GSK3β, glycogen synthase, G6Pase and phosphoenolpyruvate carboxykinase, which are related to glucose metabolism in the liver, and increase the expression of the genes PDX-1, GLUT2, MafA, and glucokinase, related to insulin secretion. Thus, oral administration of MBBP regulated insulin secretion and effectively maintained normal levels of glucose metabolism in mice, which may be done by improving the antioxidant capacity and activating insulin signaling with T2D..

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Effects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-α, PPAR-γ, and LPL mRNA expressions

Cited by 106 publications

References 40 publications

Anti-obesity effect of robusta fermented with Leuconostoc mesenteroides in high-fat diet-induced obese mice

Anti-obesity effect of robusta fermented with Leuconostoc mesenteroides in high-fat diet-induced obese mice

Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

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