Effects of dietary flaxseed oil on cholesterol metabolism of hamsters

Tzang, Bor‐Show; Yang, Shun‐Fa; Fu, Shih-Guei; Yang, Hui-Chun; Sun, Hai-Lun; Chen, Yi‐Chen

doi:10.1016/j.foodchem.2008.11.030

Cited by 93 publications

(90 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many controlled intervention studies have shown the lipidlowering effect of flaxseed oil [20][21][22][23]. In our study, the plasma and hepatic lipid levels further decreased and cholesterol secretion of rats increased in CFO group when compared with HRFO group In order to retain the most quantity of natural micronutrients, some new oil processing technology and pre-treatment methods have appeared, and studies about the effect of oil quality obtained by different crushing and refining procedures on lipid metabolism were reported.…”

Section: Discussionmentioning

confidence: 52%

“…The lipidlowering activity of flaxseed oil is also widely accepted because of the high level of ALA [3,4], the precursor to n-3 long-chain PUFA. The mechanism is based on the adjustment of LDL-receptor mRNA expression and cholesterol catabolism/output [5]. Recent researches have indicated that micronutrients in oil also exert a beneficial effect on improving lipid profiles [6,7].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of cold‐pressed and vitamin E‐enriched flaxseed oils on lipid profile and antioxidant status in high‐fat fed rats

Deng

et al. 2012

Euro J Lipid Sci & Tech

View full text Add to dashboard Cite

In this study we evaluate whether cold-pressed flaxseed oil (CFO), vitamin E-enriched hot pressed and totally refined flaxseed oils (HRFOs) characterized by different qualities of micronutrients have beneficial effects on lipid profile and antioxidant status in high-fat fed rats. Male Wistar rats were fed synthetic diets containing 10% of HRFO, CFO, low-dose (100 mg/100 g oil) vitamin E-enriched HRFO (L-HRFO) or high-dose (200 mg/100 g oil) vitamin E-enriched HRFO (H-HRFO), respectively for 4 wk. The results showed that plasma triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol levels in CFO group decreased by 12, 21, and 18% compared with HRFO group ( p < 0.05), the total hepatic lipids, TC and TG levels in CFO group were also lower significantly than those in HRFO group, but no significant differences were observed in plasma and hepatic lipid profiles among HRFO, L-HRFO, and H-HRFO groups. T-AOC levels significantly increased by 11, 12, and 22% in CFO, L-HRFO and H-HRFO groups compared with HRFO group, which was negatively correlated with the MDA levels and similar changes were observed for GSH and vitamin E levels in plasma. The CFO had a significantly higher cholesterol secretion than HRFO, L-HRFO, and H-HRFO. These results indicated that CFO had a more beneficial effect on improving lipid status and preventing oxidative stress than HRFO, and vitamin E-enriched HRFO decreased the lipid peroxidation concentration though there was no significant effect on lipid profiles.Practical applications: The cold-pressed and vitamin E-enriched HRFOs characterized by different qualities of micronutrients reduced the risk factors of cardiovascular disease. This could provide a theoretical basis for the development of high value-added functional food ingredients based on flaxseed oil or a-linolenic acid.

show abstract

Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Effects of cold‐pressed and vitamin E‐enriched flaxseed oils on lipid profile and antioxidant status in high‐fat fed rats

Deng

et al. 2012

Euro J Lipid Sci & Tech

View full text Add to dashboard Cite

show abstract

“…The olive and flaxseed oils did not differ from the control as the plasmatic lipids did. The polyunsaturated fatty acids, rich in EPA and DHA derived from sea products, presented a cardioprotective and antiatherogenic role, due to the inhibition of LDL synthesis, acceleration of LDL elimination and reductions of serum triglyceride 18 . It can also be observed that the lower -6/ -3 diet relates to a higher reduction of plasmatic lipids.…”

Section: Discussionmentioning

confidence: 99%

Flaxseed, olive and fish oil influence plasmatic lipids, lymphocyte migration and morphometry of the intestinal of Wistar rats

Rosa¹,

Sales²,

Moraes³

et al. 2010

Acta Cir. Bras.

View full text Add to dashboard Cite

Purpose: Evaluate the effect of flaxseed, olive and fish oil on the lipid profile, preservation of villosities and lymphocyte migration in the intestinal mucosa of Wistar rats. Methods: Thirty Wistar male rats were divided into four groups, which received the AIN-93M diet, with changes only to their lipid source: flaxseed, olive, fish, and soy oil (control group). The serum was separated for the biochemical parameter analysis. A histological evaluation was performed in the ileal portion. Results: The group which was fed fish oil presented lower values when compared to the other treatments for Total Cholesterol, High-density Lipoprotein Cholesterol and Triacylglycerol (p<0.05). The animals treated with fish and olive oils presented better intestinal villosities preservation. Less deposition of lymphocytes was observed in the flaxseed group (p<0.001). Conclusions: This study demonstrated that flaxseed, olive and fish oils present different responses than soy oil for the intestinal mucosa preservation and lymphocyte proliferation in Wistar rats. Key words: Vegetable Fats. Linseed Oil. Soybean Oil. Fish Oils. Morphology. Intestines. Lymphocytes. Rats. RESUMO Objetivo:Avaliar o efeito dos óleos de linhaça, oliva e peixe no perfil lipídico, preservação das vilosidades e migração de linfócitos na mucosa intestinal de ratos Wistar. Métodos: Trinta ratos Wistar foram divididos em quarto grupos e receberam dieta AIN-93M, modificando para cada grupo apenas a fonte lipídica: óleo de linhaça, oliva, peixe e soja ( grupo controle). O soro foi separado para análise dos parâmetros bioquímicos. A análise histológica foi realizada na porção ileal. Resultados: O grupo que recebeu óleo de peixe apresentou menores valores de colesterol total, lipoproteína de alta densidade e triacilglicerol (p<0.05). Os animais tratados com óleo de peixe e oliva apresentaram melhor preservação das vilosidades intestinais. Menor deposição de linfócitos foi observado no grupo tratado com óleo de linhaça (p<0.001). Conclusão: Este estudo demonstrou que os óleos de linhaça, oliva e peixe apresentam diferentes respostas em relação ao óleo de soja na preservação da mucosa intestinal e proliferação de linfócitos em ratos Wistar. Descritores: Gorduras Vegetais. Óleo de Semente do Linho. Óleo de Soja. Óleos de Peixe. Morfologia. Intestino. Linfócitos. Ratos.

show abstract

“…Tzang et al (2009) reported that the consumption of vegetable oils containing PUFAs reduces triglyceride levels, probably because of increased lipase activity. Oxidation of fats and proteins from lipoproteins and cell membranes decreases fat transport causing cell damage and leading to heart disorders (APPOLINÁRIO et al, 2011).…”

Section: Weight Evolutionmentioning

confidence: 99%

Sesame and flaxseed oil: nutritional quality and effects on serum lipids and glucose in rats

Guimarães¹,

Macedo²,

Munhoz³

et al. 2013

Food Sci. Technol (Campinas)

View full text Add to dashboard Cite

Effects of dietary flaxseed oil on cholesterol metabolism of hamsters

Cited by 93 publications

References 22 publications

Effects of cold‐pressed and vitamin E‐enriched flaxseed oils on lipid profile and antioxidant status in high‐fat fed rats

Effects of cold‐pressed and vitamin E‐enriched flaxseed oils on lipid profile and antioxidant status in high‐fat fed rats

Flaxseed, olive and fish oil influence plasmatic lipids, lymphocyte migration and morphometry of the intestinal of Wistar rats

Sesame and flaxseed oil: nutritional quality and effects on serum lipids and glucose in rats

Contact Info

Product

Resources

About