Effects of dietary fat quality on metabolic endotoxaemia: a systematic review

Cândido, Thalita Lin Netto; Silva, Laís Emilia da; Tavares, Juliana Ferreira; Conti, Ana Carolina Müller; Rizzardo, Rômulo Augusto Guedes; Alfenas, Rita de Cássia Gonçalves

doi:10.1017/s0007114520001658

Cited by 12 publications

(7 citation statements)

References 59 publications

(179 reference statements)

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“…Probably, binding LPS to toll‐like receptor 4 (TLR4) resulted in production of inflammatory cytokines such as IL‐6 and interferon gamma (IFNγ) and ME 39 . Possibly CSO, as a rich plant source of OM3FA, decreases systemic inflammation and subsequently ME 40 via inhibiting the growth of Bilophila wadsworthia and increasing the growth of A. muciniphila and B ifidobacteria , decreasing postprandial lipaemia involved in chylomicron‐LPS complex transport, influencing lipids transportation through the intestinal barrier cells phospholipid membranes, increasing endogenous activity of intestinal alkaline phosphatase (ALP) involved in LPS production and intestinal permeability improvement, and inhibiting the TLR4‐induced signalling pathway through modulation of the G protein‐coupled receptor (GPR)‐120 34 . Furthermore, anti‐inflammatory effects of OM3FA may be related to the suppression of the formation of omega‐6‐derived inflammatory lipid derivatives, production of omega‐3‐derived endocannabinoids, ethanolamides and oxylipins, as well as endocannabinoid system modulation 5,41 …”

Section: Discussionmentioning

confidence: 99%

Omega 3‐rich Camelina sativa oil in the context of a weight loss program improves glucose homeostasis, inflammation and oxidative stress in patients with NAFLD: A randomised placebo‐controlled clinical trial

et al. 2021

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Background Over the past few years, the benefits of omega‐3 fatty acids have been reported in the management of non‐alcoholic fatty liver disease (NAFLD) complications.This study evaluated the effects of Camelina sativa oil (CSO) supplementation as one of the richest dietary sources of omega‐3 fatty acids on glucose homeostasis,inflammation, metabolic endotoxemia, and oxidative stress in NAFLD patients. Methods A total of 46 patients with NAFLD were allocated to either an intervention (20 g/d CSO) or placebo (20 g/d sunflower oil) group receiving a calorie‐restricted diet for 12 weeks. Fasting plasma levels of glycemic indices, hs‐CRP, lipopolysaccharide (LPS), antioxidant enzymes activity, total antioxidant capacity (TAC), malondialdehyde (MDA), 8‐iso‐prostaglandin F2α (8‐iso‐PGF2α), and uric acid were measured at baseline and post‐intervention. Results The CSO supplementation led to significant differences in insulin concentration, homeostasis model assessment of insulin resistance (HOMA‐IR), hs‐CRP, LPS, TAC, superoxide dismutase (SOD) activity, MDA and 8‐iso‐PGF2α between the two groups at end of the study (ANCOVA, P < .05). Hs‐CRP decreased significantly in both groups (pair‐t‐test, P < .05). Insulin concentration, quantitative insulin sensitivity check index, LPS, TAC, SOD, glutathione peroxidase activity, MDA and 8‐iso‐PGF2α changed significantly only in CSO group (P < .05). Conclusion These findings indicate that CSO may improve glycemia, inflammation, metabolic endotoxemia, and oxidative stress status in patients with NAFLD.

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Section: Discussionmentioning

confidence: 99%

Omega 3‐rich Camelina sativa oil in the context of a weight loss program improves glucose homeostasis, inflammation and oxidative stress in patients with NAFLD: A randomised placebo‐controlled clinical trial

et al. 2021

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“…42 Possibly CSO, as a source of OM3FA decreases systemic inflammation and subsequently ME 43 via inhibiting the growth of Bilophila wadsworthia and increasing the growth of A. muciniphila and bifidobacteria, decreasing postprandial lipaemia involved in chylomicron-LPS complex transport, influencing lipids transportation through the intestinal barrier cells phospholipid membranes, increasing endogenous activity of intestinal ALP involved in LPS production and intestinal permeability improvement, and inhibiting the TLR4-induced signaling pathway through modulation of the G protein-coupled receptor (GPR)-120. 37 Furthermore, anti-inflammatory effects of OM3FA may be related to the suppression of the formation of omega-6-derived inflammatory lipid derivatives, production of omega-3-derived endocannabinoids, ethanolamides and oxylipins, as well as endocannabinoid system modulation. 5,44 In the current study, another effect of CSO in patients with NAFLD was the modulation of OS biomarkers.…”

Section: Discussionmentioning

confidence: 99%

Camelina oil in the context of a weight loss programs improves glucose homeostasis, inflammation and oxidative stress in NAFLD patients: A randomized, triple -blind, placebo-controlled clinical trial

Musazadeh

Dehghan

salehghadimi

et al. 2021

Preprint

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Background: Over the past few years, the benefits of co-administration of omega-3 and antioxidants have been reported in the management of non-alcoholic fatty liver disease (NAFLD) complications.This study evaluated the effects of Camelina sativa oil (CSO) supplementation as one of the richest dietary sources of omega-3 fatty acids on glucose homeostasis,inflammation, metabolic endotoxemia, and oxidative stress in NAFLD patients. Methods: In all, 43 subjects with NAFLD were allocated to either an intervention (20g/d CSO) or placebo (20g/d sunflower oil) group receiving a calorie-restricted diet for 12 weeks. Fasting serum levels of glycemic indices, hs-CRP, endotoxin, antioxidant enzymes activity, total antioxidant capacity (TAC), malondialdehyde (MDA), 8-iso-prostaglandin F2α (8-iso-PGF2α), and uric acid were measured at baseline and post-intervention. Results: CSO intake led to a significant decrease in insulin concentration (-17.49%), homeostasis model assessment of insulin resistance (HOMA-IR) (-20%), high-sensitive C-reactive protein (hs-CRP), (-12.94%), lipopolysaccharide endotoxin (-32.55%), malondialdehyde (MDA) (-18.75%), 8-iso-prostaglandin F2α (8-iso-PGF2α) (-19.55%) and a significant increase in the levels of total antioxidant capacity (TAC) (31.82%) and superoxide dismutase activity (10.22%) in the CSO group compared with the placebo group. Also, there was no significant difference between the two groups in fasting plasma glucose, quantitative insulin sensitivity check index (QUICKI), catalase, glutathione peroxidase activity, and uric acid level. In addition, within-group analyses showed a significant reduction of insulin, QUICKI, hs-CRP, and endotoxin levels in the intervention group. Conclusion: These findings indicate that CSO may improve glycemic, inflammation, metabolic endotoxima, oxidative stress status, and mental health in patients with NAFLD.

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“…Changes in dietary patterns with excessive HFD consumption may be a dominant factor required to provoke a major shift in the composition of intestinal microbiota, with changes in the composition of Bacteroidetes and Firmicutes, and leads to metabolic endotoxemia . The change in gut microbiota could result in increased LPS levels due to increased endotoxin production, and the gut microbiota is characterized by reduction in the beneficial bacteria such as Lactobacillus spp., Bifidobacterium spp., and Bacteroides-Prevotella spp. , Studies demonstrated that SFA also seem to act as a major risk factor for the transient rise in endotoxemia, associated with increasing postprandial LPS concentrations . Metabolic endotoxemia and elevated systemic LPS contribute to increased intestinal permeability .…”

Section: Gut Microbial and Dietary Influence On Metabolic Endotoxemiamentioning

confidence: 99%

“…224,225 Studies demonstrated that SFA also seem to act as a major risk factor for the transient rise in endotoxemia, associated with increasing postprandial LPS concentrations. 226 Metabolic endotoxemia and elevated systemic LPS contribute to increased intestinal permeability. 227 An elevated level of intestinal LPS can destruct the intestinal epithelial cell tight junction through the TLR4 (Toll-like receptor 4) signal transduction pathway as well.…”

Section: Metabolic Endotoxemiamentioning

confidence: 99%

Dietary Influence on the Dynamics of the Human Gut Microbiome: Prospective Implications in Interventional Therapies

Adithya

Rajeev

Selvin

et al. 2021

ACS Food Sci. Technol.

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Dietary factors have a significantly influential role in regulating body homeostasis by modulating gut microbial composition, supplying different sources of nutrients, and inducing changes in the body. Unhealthy short- or long-term modifications in the dietary pattern can alter the intestinal microbiota, leading to a loss of metabolic control and physiological activities, which is a growing concern as per recent studies. Diets, mainly containing high-fat, high-carbohydrate, and low-fiber content, are predisposing factors that could lead to gut dysbiosis, thereby causing health disorders. In comparison with different dietary patterns, vegan and vegetarian diets containing plentiful fruits and vegetables are known for anti-inflammatory properties and eliminating gut dysbiosis, causing improvement in intestinal well-being. Microbes in the gut can regulate cholesterol metabolism, blood glucose homeostasis, insulin sensitivity, and many other metabolic pathways; hence, the dysbiosis of microbiota leads to metabolic disorders such as cardiovascular disorders, type 2 diabetes, obesity, etc. Recent research advancements have expanded the knowledge on the potentiality of the gut microbiome in regulating mood and behavior. The rebiosis strategy includes the treatment of microbiome-associated illness via an increment of microbial resilience within the gut by administering probiotics or prebiotics. Therefore, over the last few decades, health benefits offered by probiotics and prebiotics have been the focus of intensive research. Psychobiotics is also an emerging novel antidepressant therapy that influences the control of mental conditions through the application of probiotics that could interact through the gut–brain axis. This review aims to examine the latest research evaluating the impact of diet on homeostasis and host body well-being with a special reference to the importance of gut microbiota and its modulation against dysbiosis.

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Effects of dietary fat quality on metabolic endotoxaemia: a systematic review

Cited by 12 publications

References 59 publications

Omega 3‐rich Camelina sativa oil in the context of a weight loss program improves glucose homeostasis, inflammation and oxidative stress in patients with NAFLD: A randomised placebo‐controlled clinical trial

Omega 3‐rich Camelina sativa oil in the context of a weight loss program improves glucose homeostasis, inflammation and oxidative stress in patients with NAFLD: A randomised placebo‐controlled clinical trial

Camelina oil in the context of a weight loss programs improves glucose homeostasis, inflammation and oxidative stress in NAFLD patients: A randomized, triple -blind, placebo-controlled clinical trial

Dietary Influence on the Dynamics of the Human Gut Microbiome: Prospective Implications in Interventional Therapies

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