Curcumin has been shown to prevent and inhibit carcinogeninduced tumorigenesis in different organs of rodent carcinogenesis models. Our objective is to study global gene expression profiles elicited by curcumin in mouse liver and small intestine as well as to identify curcuminregulated nuclear factor E2-related factor 2 (Nrf2) -dependent genes. Wild-type C57BL/6J and Nrf2 knockout C57BL/6J/Nrf2(À/À) mice were given a single oral dose of curcumin at 1,000 mg/kg. Liver and small intestine were collected at 3 and 12 hours after treatments.