Efficacy of traditional Chinese medicine in treating cancer

Nie, Jing; Zhao, Chen; Deng, Li; Chen, Jia; Yu, Bin; Wu, Xiaoyi; Peng, Ping; Chen, Xiaoyin

doi:10.3892/br.2015.537

Cited by 93 publications

(57 citation statements)

References 74 publications

(62 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus far, combination therapy based on traditional cytotoxins plus personalized treatments seems to offer the best antileukemic effects and higher response rates with manageable toxic effects. An increasing number of patients select to use naturopathic therapy with traditional Chinese medicine (TCM) for adjuvant treatment (Nie et al 2016). TCM treatments, including herbal compounds and herbal monomers, are proposed to work on multiple targets in whole-body systems to fight against the disease (Bailly 2009;Pan et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Curcumin inhibited the growth and invasion of human monocytic leukaemia SHI-1 cells in vivo by altering MAPK and MMP signalling

Zeng

Jiang

et al. 2019

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Curcumin, a polyphenolic compound extracted from the rhizome of the tropical plant Curcuma longa L. (Zingiberaceae), has been considered as a cancer chemopreventive drug by American National Cancer Institute. Objective: To examine the effect of curcumin on acute monocytic leukaemia SHI-1 cells in vivo. Materials and methods: The SHI-1 cells (1 Â 10 6 cells in 0.1 mL PBS) were injected subcutaneously into the right flanks of the female SCID mice. Curcumin dissolved in olive oil (15 and 30 mg/kg) was administered (i.p.) to mice once a day for 15 days while the control group received olive oil injection. Tumour proliferation and apoptosis were examined by PCNA, TUNEL and cleaved caspase-3 staining. The expression of MAPK, NF-jB, MMP9, MMP2 and vimentin were confirmed by RT-PCR, immunohistochemistry or western blotting. Results: Administration of curcumin significantly inhibited tumour growth, as the tumour weight decreased from 0.67 g (control) to 0.47 g (15 mg/kg) and 0.35 g (30 mg/kg). Curcumin inhibited the expression of PCNA and increased the degree of TUNEL and cleaved caspase-3 staining in tumour tissue. The results of western blotting showed that curcumin treatment inhibited NF-jB and ERK signalling while activating p38 and JNK. Moreover, curcumin attenuated the mRNA transcription and protein expression of MMP2 and MMP9. Curcumin also suppressed the level of vimentin. Discussion and conclusions: Our study demonstrates that curcumin can inhibit the growth and invasion of human monocytic leukaemia in vivo, suggesting the possible use of curcumin for anti-metastasis in leukaemia and the value of determining its unique target.

show abstract

Section: Discussionmentioning

confidence: 99%

Curcumin inhibited the growth and invasion of human monocytic leukaemia SHI-1 cells in vivo by altering MAPK and MMP signalling

Zeng

Jiang

et al. 2019

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…The cancer treatments available to patients include chemotherapy, radiotherapy, surgery, immunotherapy, or a combination of them Saeed et al 2016;Saluja et al 2016;Nie et al 2016). Although many cancer types are curable with chemotherapeutic cytotoxic agents, sometimes chemoresistance against cancer therapeutic agents develops.…”

Section: Mechanisms Of Drug Resistance In Cancermentioning

confidence: 99%

Targeting multidrug resistance in cancer by natural chemosensitizers

et al. 2019

View full text Add to dashboard Cite

Background: Statistics on cancer incidence and mortalities indicate that this disease still has a fatal outcome for a majority of patients due to non-sufficient treatment. The options available for cancer treatment include chemotherapy, which still commands a leading position in clinical oncology. A major obstacle to successful chemotherapy is the development of cellular resistance to multiple structurally unrelated anticancer drugs. This phenomenon has been termed multidrug resistance (MDR), which occurs in a majority of cancer patients. MDR is mainly due to the overexpression of ABC transporters which extrude chemotherapeutic drugs outside of cancer cells. A plethora of synthetic chemosensitizers have been described during the past decades that block ABC transporter function to reverse their MDR. However, none of them reached clinical routine application as of yet. In this review, we highlight the potential of natural products derived from plants, marine organisms, fungi, and other sources as chemosensitizers to the targeted major ABC transporters (ABCB1, ABCC1, and ABCG2). Conclusion: Natural compounds may serve as lead compounds for the development of novel ABC transporter inhibitors with improved pharmacological features that can be used as adjuvant therapy to enhance the efficacy of chemotherapeutic drugs against MDR.

show abstract

“…As cancer is one of the leading causes of death in China , significant resources have been devoted to study the effects of TCM alongside Western medical treatments. Clinical and preclinical trials have demonstrated the efficacy of Chinese medicinal herbs as adjuvant treatments by enhancing the effects of conventional cancer therapies, reducing toxicity, and improving quality of life factors (Nie et al, 2016;Xiang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Hoffman

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

Traditional Chinese medicine is an accepted and integral part of clinical cancer management alongside Western medicine in China. However, historically TCM physicians were unaware of the chemical constituents of their formulations, and the specific biological targets in the body. Through HPLC, flow cytometry, and other processes, researchers now have a much clearer picture of how herbal medicine works in conjunction with the immune system in cancer therapy. Among them, the regulation of tumor-related T cells plays the most important role in modulating tumor immunity by traditional Chinese medicine. Encouraging results have been well-documented, including an increase in T cell production along with their associated cytokines, enhanced regulation of Tregs and important T cell ratios, the formation and function of Tregs in tumor microenvironments, and the promotion of the number and function of normal T Cells to reduce conventional cancer therapy side effects. Chinese herbal medicine represents a rich field of research from which to draw further inspiration for future studies. While promising agents have already been identified, the vast majority of Chinese herbal mechanisms remain undiscovered. In this review, we summarize the effects and mechanisms of specific Chinese herbs and herbal decoctions on tumor related T cells.

show abstract

Efficacy of traditional Chinese medicine in treating cancer

Cited by 93 publications

References 74 publications

Curcumin inhibited the growth and invasion of human monocytic leukaemia SHI-1 cells in vivo by altering MAPK and MMP signalling

Curcumin inhibited the growth and invasion of human monocytic leukaemia SHI-1 cells in vivo by altering MAPK and MMP signalling

Targeting multidrug resistance in cancer by natural chemosensitizers

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Contact Info

Product

Resources

About