Effects of dietary administering chitosan on growth performance, jejunal morphology, jejunal mucosal sIgA, occluding, claudin-1 and TLR4 expression in weaned piglets challenged by enterotoxigenic Escherichia coli

Effects of dietary supplementation of chitosan on immune and antioxidative function in beef cattle

“…Furthermore, dietary supplementation of CHI in piglets increased serum immunoglobulins and recouped a loss which was caused by early weaning (Yin et al 2008;Li et al 2013). Xiao et al (2013) added 50 mg/kg chlortetracycline or 300 mg/kg CHI in the diet of weaned piglets and showed that the expression of jejunal mucosal secretory IgA (sIgA) protein was higher in the CHI group than in both control and chlortetracycline groups, which indicated CHI could improve the intestinal mucosal immune function. The current results have been similar to these reports, especially on IgA which plays an important role in the prevention of allergic reactions by the inhibition of allergen absorption (Metcalfe 1991), which is beneficial for the improvement of humoral immunity in beef cattle.…”

Effects of Chitosan on Intestinal Inflammation in Weaned Pigs Challenged by Enterotoxigenic Escherichia coli

“…Animals and experimental design were same with the previous reported paper [18]. Thirty 21-day-old piglets (Duroc×Landrace×Yorkshire, initial BW of 5.65±0.27) were challenged with enterotoxigenic Escherichia coli during a preliminary trial period.…”

“…However, it is still unclear whether dietary supplementation with COS can alleviate inflammatory bowel diseases and how COS affects intestinal inflammation. Our previous studies showed that supplemental COS in weaned piglets decreased the feed conversion ratio and improved the intestinal morphology, intestinal connectivity, and intestinal mucosal immunity [18]. We established an Escherichia coli model of post-weaning diarrhea in early-weaned piglets, and used this new model to investigate the effects of COS on intestinal inflammation by daily monitoring of diarrhea and analyzed the effects of COS on inflammatory responses by determining TLR4 and calprotectin protein expression, as well as the concentration and mRNA expression of IL-1β, IL-6 and TNF-α.…”

Supplementation of the sow diet with chitosan oligosaccharide during late gestation and lactation affects hepatic gluconeogenesis of suckling piglets

“…Chitosan oligosaccharides (COS), the hydrolyzed product of chitosan, is a mixture of oligomers of b-1,4-linked d-glucosamine residues (Xiao et al, 2013(Xiao et al, , 2014. It is abundant in the exoskeletons of crustaceans and the cell walls of fungi and insects (Pae et al, 2001).…”

“…It is abundant in the exoskeletons of crustaceans and the cell walls of fungi and insects (Pae et al, 2001). COS has the potential ability to improve food quality (Oliveira et al, 2008;Seyfarth et al, 2008;Wang et al, 2011) and human and animal health (Lee et al, 2003;Sun et al, 2009;Yin et al, 2008Yin et al, , 2010Xia et al, 2011;Xiao et al, 2013;Kong et al, 2014;Xiong et al, 2015). Several studies showed that COS can be used as an antidiabetic agent for its effect on promotion of glucose tolerance and reduction of the plasma glucose in diabetic rats (Lee et al, 2003;Kim et al, 2009aKim et al, ,b, 2014.…”