Effects of dibutyryl cyclic amp and a new cyclic nucleotide on gastric acid secretion in the rat

Effects of cyclic AMP, ouabain and furosemide on ion transport in isolated canine gastric mucosa.

“…Theophylline, an inhibitor of phosphodiesterase that results in an increase in intracellular cyclic AMP, had similar but lesser effects than DBcAMP. Stimulation of H+ secretion by DBcAMP has also been reported for frog (Shoemaker, Buckner, Spenney & Sachs, 1974), necturus (Spenney, Strych, Nakajima, Hirschowitz & Sachs, 1972), rat (Brennan, Arkbakov, Stefankiewicz & Groves, 1975) and rabbit (Fromm, Schwartz & Ouijano, 1975) gastric mucosae in vitro, and for rat stomach (Jawaharlal & Berti, 1972). However, DBcAMP did not initiate acid secretion in dog stomach in vivo (Mao, Shanbour, Hodgins & Jacobson, 1972).…”

Effect of a sulphated glycopeptide on rat gastric acid secretion stimulated by histamine, bethanechol, pentagastrin and dibutyryl cyclic AMP

“…The stimulatory action of DB-cAMP and of theophylline on gastric secretion has also been demonstrated in vivo by a technique involving perfusion of the rat gastric mucosal surface with solutions containing these agents (Shaw & Ramwell, 1968). When DB-cAMP was administered intravenously it also enhanced rat gastric secretion (Jawaharlal & Berti, 1972;Whittle, 1972). There is, therefore, some evidence linking cyclic AMP to the process of acid secretion.…”

Μεταβολες Των Κυκλικων Νουκλεοτιδιων Και Της Γαστρινης Μετα Απο Χορη- Γηση Ουσιων Που Προαγουν Η Αναστελλουν Τη Γαστρικη Εκκριση

“…Παρό μοια αποτελέσματα, έχουν βρεθεί μετά από χορήγηση πενταγαστρίνης (26,104,196,303,369,370,371) και carbachol (303). Βρέθηκε ακόμα, ότι το Dibutyryl-c AMP προάγει τή γαστρική έκκριση (208,275,277,302,303,305,370) και ενεργοποιεί τή καρβονική άνυδράση (302,303,370,371). Ή θεοφυλλίνη, αυξάνει τήν έκκριση των ιόντων υδρογόνου (294), τήν απάντηση του γαστρικοί) βλεννογόνου στή χορήγηση Dibutyryl-cAMP (276,302) καί τή συγκέντρωση του cAMP του γαστρικού βλεννο γόνου (302,303).…”