Effects of curcumin on crevicular levels of IL‐1β and CCL28 in experimental gingivitis

Abstract

Background: Curcumin has anti-inflammatory properties. The aim of this study was to compare interleukin-1b (IL-1b) and chemokine (C-C motif) ligand 28 (CCL28) levels following a topical application of curcumin (CRM), chlorhexidine (CHX) and chlorhexidine-metronidazole (CHX-MTZ) in an experimental gingivitis human model. Methods: Sixty systemically healthy selected subjects were randomly assigned to one of three topical antigingivitis gels. Each gel was applied twice daily for 10 minutes as the sole method of oral hygiene for 29 days on the test quadrant only. Modified gingival index (MGI), plaque index (PI), bleeding on probing (BOP) and probing depth (PD) were assessed at baseline, 29 days and 60 days. Estimation of IL-1b and CCL28 levels in gingival crevicular fluid was done at baseline and at 29 days. Results: The increase of IL-1b in the CRM (14.52 AE 16.6 pg/ml) and CHX-MTZ (31.63 AE 15.96) groups was significantly less than that of the CHX group (70.55 AE 38.81). Similar results were also observed for CCL28 (CRM: 8.12 AE 8.78 pg/ml; CHX-MTZ: 12.81 AE 18.68; CHX: 41.15 AE 22.82). All groups had a significant increase in MGI, PI and BOP at 29 days. Conclusions: The anti-inflammatory potential of topical curcumin was similar to CHX-MTZ but superior to CHX in affecting IL-1b and CCL28 levels.

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

“…As an anti‐inflammatory, curcumin mouthwash was found to be almost as good as CHX and hence it may act as an efficacious adjunct to mechanical periodontal therapy (Muglikar et al , ). Similarly, the anti‐inflammatory potential of topical curcumin was found to be comparable with that of CHX‐MTZ and higher than CHX in affecting the levels of IL‐1β and CCL28 (Pulikkotil and Nath, ). Besides curcumin, in another clinical study turmeric mouthwash was found to be useful as an adjunct to mechanical plaque control methods in the prevention of plaque and gingivitis (Waghmare et al , ).…”

“…Gingivitis is one of the most common inflammatory periodontal diseases that affect more than 80% of the world's population (Pulikkotil and Nath, ). Curcumin therapy holds high potential as a treatment of gingivitis.…”

Evaluation of a curcumin-containing mucoadhesive film for periodontal postsurgical pain control

“…Pulikkotil and Nath[48] are the only ones who evaluated the effect of curcumin oral gel on experimental gingivitis by comparing the levels of IL-1β and chemokine ligand 28 at baseline and 29 days, showing its anti-inflammatory mechanism of action on a molecular level in gingivitis in humans. No studies are reported that assessed the effect of curcumin on postoperative facial or internal swelling after periodontal surgery.…”

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“…It could be commonly utilized as food dye and spice in curries. 1,2,3 In recent years, many researchers discovered that CUR and its derivatives exhibited some amazing properties such as antioxidant, anti-inflammation, anti-microbial, anticancer and anti-mutagenic with low intrinsic toxicity. 4,5 However, its poor water-solubility restricted its practical application in biology to a great degree.…”