Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

Kunnumakkara, Ajaikumar B.; Bordoloi, Devivasha; Padmavathi, Ganesan; Monisha, Javadi; Roy, Nand Kishor; Prasad, Sahdeo; Aggarwal, Bharat B.

doi:10.1111/bph.13621

Cited by 765 publications

(563 citation statements)

References 179 publications

(188 reference statements)

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“…It has been demonstrated by the epidemiological, clinical and animal studies that curcumin has antimicrobial, antioxidant, antiinflammatory, antifungal, antiinfectios, antiviral, antimutagenic, anticarcinogenic, antimetastatic, antigrowth, antiarthritic, antiatherosclerotic, antidepressant, antiaging, antidiabetic, wound healing memoryenhancing activities and neuroprotective properties (Priyadarsini 1997, Limtrakul et al 1997, Pandya et al 2000, Anand et al 2008, Aggarwal et al 2013a, Gopal et al 2014, Kunnumakkara et al 2016. Many studies have demonstrated the anticancer effect of curcumin in a verity tumors as gastrointestinal, breast, pancreatic and hepatic cancer (Anand et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Effect of Curcumin On the Genotoxicity Induced By Alkylating Agents

Isitez¹,

Çiğerci²

2017

AKU-J. Sci. Eng.

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DNA damage due to genotoxic stress is an important type of stress which organisms are exposed during the their life. The direct-acting alkylating agent methyl methanesulfonate (MMS), is covalently linked to DNA and cause DNA damage, creating an indirect effect of the alkylating agent cyclophosphamide (CP) cause to DNA damage by changing the function of cellular proteins. In this study, the effects of curcumin on MMS and CP treated mice DNA damage, total antioxidant capacity, total oxidant capacity (oxidative stress index) and genotoxicity markers such as micronucleus index, cell growth arrest and induced DNA damage, which is Gadd45 and Gadd153 genes expression levels were investigated.Curcumin reduce DNA damage, the number of micronucleus and oxidative stres occurred by both MMS and CP induction. Curcumin's protective effect on DNA damage was provided by inducing Gadd45 and Gadd153 mRNA expression levels. We could state that curcumin, a phenolic compound show protective effects before the damage. In brief, curcumin has both antioxidant and antigenotoxic effects. Alkilleyici Ajanlar Tarafından Uyarılan Genotoksisite Üzerine Curcumin'in Etkisi Anahtar kelimelerCurcumin, Alkilleyici ajanlar, Genotoksisite, Comet assay, Gen ekspresyonu. ÖzetDNA hasarı organizmaların yaşamı boyunca maruz kaldığı önemli bir genotoksik stres türüdür. Doğrudan etkili alkilleyici ajanlardan olan metil metansülfonat (MMS), DNA'ya kovalent olarak bağlanarak DNA'da hasar oluştururken, dolaylı yoldan etkili alkilleyici ajanlardan olan siklofosfamid (SP) ise hücresel proteinlerin fonksiyonlarını değiştirerek DNA hasarına sebep olur. Bu araştırmada, deneysel olarak MMS ve SP uygulanan farelerde DNA hasarı, total antioksidan kapasite, total oksidan kapasite (oksidatif stres indeksi) ile genotoksisite belirteci mikronukleus indeksi ve hücre büyümesini durduran ve indüklenmiş DNA hasarının belirteci olan genlerden Gadd45 ve Gadd153'ün ifadelerindeki değişiklikler ile bunlara curcumin'in etkileri araştırıldı. Önce curcumin, sonra MMS ve SP'in uygulandığı gruplarda, curcumin'in DNA hasar derecesini mononükleer lökositlerde azalttığı, kemik iliğinde oluşan mikronukleus sayısını azalttığı, plazmada oksidatif stresi azalttığı ve indüklenmiş DNA hasarının belirteci olan Gadd45 ve Gadd153'ün mRNA ekspresyon düzeylerinin uyarılmasını sağlayarak koruyucu özellik gösterdiği bulundu. Sonuç olarak, fenolik bir bileşik olan curcumin'in, hasar oluştuktan sonra değil de, hasar oluşmadan önce koruyucu özellik göstererek antioksidan ve antigenotoksik özelliğe sahip olduğu bulundu.

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Section: Discussionmentioning

confidence: 99%

Effect of Curcumin On the Genotoxicity Induced By Alkylating Agents

Isitez¹,

Çiğerci²

2017

AKU-J. Sci. Eng.

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“…The powdered rhizomes from C. longa are an essential part of curry which is used as a spice in many Hindustani dishes [51]. C. longa preparations are furthermore used, among others, as a diuretic; to stimulate blood low in the pelvic area; to treat fevers with jaundice, hepatitis, and malaria; to prevent excessive menstrual pain; to enhance mental functioning and well-being; and externally for herpes, bruises, wounds, and rheumatism [66]. The leaves from the aromatic plant O. tenuilorum-either fresh, dried, powdered, or as a tea-would treat a similar variety of diseases including stress and a disturbed homeostasis [67].…”

Section: Medicinal and Ritual Plants Used By Hindustanismentioning

confidence: 99%

“…Furthermore, the juice collected from C. longa rhizomes is, together with that from Z. zerumbet rhizomes, used for treating stomach ache, and together with the macerated rhizomes of C. aeruginosa, and Z. zerumbet, a grated onion, sugar, and a packet of cooked Glycine max soybeans, for treating pinworm infections in children [74]. The potential health beneits of C. longa may be ascribed to the antimicrobial and anti-inlammatory properties of curcuminoids in the plant [66].…”

Section: Medicinal and Ritual Plants Used By Javanesementioning

confidence: 99%

Meeting of the Minds: Traditional Herbal Medicine in Multiethnic Suriname

Mans¹,

Ganga²,

Kartopawiro³

2017

Aromatic and Medicinal Plants - Back to Nature

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The Republic of Suriname (South America) is located on the Guiana Shield, one of the regions with the highest biodiversity and the largest expanse of undisturbed tropical rain forest in the world. The population of almost 570,000 consists of a unique blend of ethnic groups and cultures from all continents. These include Indigenous Amerindians, the original inhabitants; Maroons, the descendants of runaway slaves who had been shipped from Africa between the seventeenth and the nineteenth century; Creoles, a generic term referring to mixed blacks and whites; the descendants from indentured workers from China, India, and Java (Indonesia) who arrived between the second half of the nineteenth and the irst half of the twentieth century; as well as immigrants from various Middle Eastern, European, Caribbean, and South American countries. All these groups have made their own speciic contribution to Suriname's traditional medicine, which has resulted in a myriad of remedies against many disorders, mainly employing a variety of plants. This chapter presents a brief history of Suriname, addresses the ethnopharmacological practices of Maroons and Creoles as well as Hindustanis and Javanese, and concludes with a few remarks on the previsions provided by the country's rich plant-based traditional medicine.

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“…Extensive research has verified that continued oxidative stress and oxidative damage often results in chronic inflammation at the cellular level [2][3][4][5][6][7]. These cellular changes in turn mediate many chronic diseases that share clinically similar symptoms such as fevers, skin disorders, lymphadenopathy, joint pain; joint swelling, and musculoskeletal involvement [8].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Molecular World of Turmeric: An Alternative in the Treatment of Chronic Inflammation

Trubilla¹

2017

MOJCSR

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Autoimmune and auto-inflammatory diseases affect over 50 million Americans. Both of these disorders share common characteristics such as frequent episodes of inflammation followed by symptoms that may include rash, fever, joint pain, and joint swelling. These symptoms result when the body attacks its own tissue due to dysregulation of the innate immune system causing increased inflammation throughout the body. Over the past decade, numerous research articles have shows the benefit of complementary medicine and nutrition in the treatment of chronic inflammation. Despite evidenced based clinical research that supports the use of alternative medicine, many insurance companies and medical providers choose not to advocate for the use of these supplements. This paper reviewed the ongoing proposed benefits of Turmeric, a spice from the root Curcuma longa, a member of the ginger family as an anti-inflammatory agent. In-vitro and in-vivo research show various activities, such as anti-inflammatory, antiviral, antifungal, cytokines release, antioxidant, immunomodulatory, enhancing of the apoptotic process, and antiangiogenic properties of Turmeric. Challenges of treating and managing chronic inflammatory disease, and alternative treatment options were also highlighted.

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Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

Abstract: This article is part of a themed section on Principles of Pharmacological Research of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.11/issuetoc.

Cited by 765 publications

References 179 publications

Effect of Curcumin On the Genotoxicity Induced By Alkylating Agents

Effect of Curcumin On the Genotoxicity Induced By Alkylating Agents

Meeting of the Minds: Traditional Herbal Medicine in Multiethnic Suriname

Exploring the Molecular World of Turmeric: An Alternative in the Treatment of Chronic Inflammation

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