Effects of curcumin, its analogues, and metabolites on various cancers: focusing on potential mechanisms

Şanlıer, Nevin; Kocabaş, Şule; Erdoğan, Kadriye; Sanlier, Nazlı Tunca

doi:10.1080/87559129.2022.2067173

Cited by 5 publications

(5 citation statements)

References 124 publications

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“…This compound suppresses the development of tumors, which increases the bacterial richness of Lactobacillales and decreases the order of Coriobacteriales. 97…”

Section: Proteinsmentioning

confidence: 99%

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Modulation of gut‐microbiota through probiotics and dietary interventions to improve host health

Dasriya,

Samtiya,

Ranveer

et al. 2024

J Sci Food Agric

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Dietary patterns play an important role in regards to the modulation and control of the gut microbiome composition and function. The interaction between diet and microbiota plays an important role in order to maintain intestinal homeostasis, which ultimately afftect the host's health. Diet directly impacts the microbes that inhabit the gastrointestinal tract (GIT), which then contributes to the production of secondary metabolites, such as short‐chain fatty acids, neurotransmitters, and antimicrobial peptides. Dietary consumption with genetically modified probiotics can be the best vaccine delivery vector and protect cells from various illnesses. A holistic approach to disease prevention, treatment, and management take these intrinsically linked diet‐microbes, microbe‐microbe interactions, and microbe‐host interactions into account. Dietary components, such as fibre can modulate beneficial gut microbiota, and they have resulting ameliorative effects against metabolic disorders. Medical interventions, such as antibiotic drugs can conversely have detrimental effects on gut microbiota by disputing the balance between Bacteroides and firmicute, which contribute to continuing disease states. We summarise the known effects of various dietary components, such as fibres, carbohydrates, fatty acids, vitamins, minerals, proteins, phenolic acids, and antibiotics on the composition of the gut microbiota in this paper in addition to the beneficial effect of genetically modified probiotics and consequentially its role in regards to shaping human health.This article is protected by copyright. All rights reserved.

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“…This compound suppresses the development of tumors, which increases the bacterial richness of Lactobacillales and decreases the order of Coriobacteriales. 97…”

Section: Proteinsmentioning

confidence: 99%

“…Curcumin, which is an effective constituent of the Curcuma longa , has beneficial health effects, such as anti‐proliferative, antioxidant, and anti‐inflammatory properties. This compound suppresses the development of tumors, which increases the bacterial richness of Lactobacillales and decreases the order of Coriobacteriales 97 …”

Section: Dietary Componentsmentioning

confidence: 99%

Modulation of gut‐microbiota through probiotics and dietary interventions to improve host health

Dasriya,

Samtiya,

Ranveer

et al. 2024

J Sci Food Agric

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show abstract

“…In addition, curcumin and its analog and metabolite have an antimetastatic activity by decreasing Hsp70 and toll-like receptor (TLR4). Moreover, it induces apoptosis via increasing caspase-9 and caspase-3 [ 41 ]. Resveratrol stimulates mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) [ 42 ] and nuclear factor erythroid 2-related factor 2(Nrf2) [ 43 ].…”

Section: Chemoprevention Mechanisms Of Plant-derived Productsmentioning

confidence: 99%

“…Consequently, it suppresses cancer development [ 337 ]. Likewise, luteolin has a dual action in downregulating/upregulating autophagy in cancer therapy [ 41 ]. For instance, in vitro study has shown that luteolin has an antitumor effect in the HCC cell line SMMC-7721 by inducing autophagy [ 339 ].…”

Section: Plant-derived Natural Products With Potential Anticancer Eff...mentioning

confidence: 99%

Plants as a Source of Anticancer Agents: From Bench to Bedside

et al. 2022

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Cancer is the second leading cause of death after cardiovascular diseases. Conventional anticancer therapies are associated with lack of selectivity and serious side effects. Cancer hallmarks are biological capabilities acquired by cancer cells during neoplastic transformation. Targeting multiple cancer hallmarks is a promising strategy to treat cancer. The diversity in chemical structure and the relatively low toxicity make plant-derived natural products a promising source for the development of new and more effective anticancer therapies that have the capacity to target multiple hallmarks in cancer. In this review, we discussed the anticancer activities of ten natural products extracted from plants. The majority of these products inhibit cancer by targeting multiple cancer hallmarks, and many of these chemicals have reached clinical applications. Studies discussed in this review provide a solid ground for researchers and physicians to design more effective combination anticancer therapies using plant-derived natural products.

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“…Curcumin hinders cellular growth, restrains invasion and movement, stimulates programmed cell death, triggers the self-degradation of cells, diminishes inflammation, and governs diverse cellular mechanisms in the advancement of cancer [14]. Curcumin is considered safe and well tolerated, even when administered at high dosages [15]. However, the effectiveness of curcumin in treating cancer is limited due to its restricted absorption and utilization by the body [16].…”

Section: Introductionmentioning

confidence: 99%

Conformational Analysis of 1,5-Diaryl-3-Oxo-1,4-Pentadiene Derivatives: A Nuclear Overhauser Effect Spectroscopy Investigation

Belov,

Brel,

Sobornova

et al. 2023

IJMS

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1,5-Diaryl-3-Oxo-1,4-Pentadiene derivatives are intriguing organic compounds with a unique structure featuring a pentadiene core, aryl groups, and a ketone group. This study investigates the influence of fluorine atoms on the conformational features of these derivatives in deuterated chloroform (CDCl3) solution. Through nuclear magnetic resonance (NMR) spectroscopy and quantum chemical calculations, we discerned variations in interatomic distances and established predominant conformer proportions. The findings suggest that the non-fluorinated entity exhibits a uniform distribution across various conformer groups. The introduction of a fluorine atom induces substantial alterations, resulting in the predominance of a specific conformer group. This structural insight may hold the key to their diverse anticancer activities, previously reported in the literature.

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Effects of curcumin, its analogues, and metabolites on various cancers: focusing on potential mechanisms

Cited by 5 publications

References 124 publications

Modulation of gut‐microbiota through probiotics and dietary interventions to improve host health

Modulation of gut‐microbiota through probiotics and dietary interventions to improve host health

Plants as a Source of Anticancer Agents: From Bench to Bedside

Conformational Analysis of 1,5-Diaryl-3-Oxo-1,4-Pentadiene Derivatives: A Nuclear Overhauser Effect Spectroscopy Investigation

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