Introduction: The etiologies of diminished ovarian reserve (DOR) are still poorly understood, and many factors such as age, autoimmunity, genetics, idiopathicity, iatrogenesis, and oxidative stress (OS) play a role. Oxidative cellular damage increases following reactive oxygen species (ROS)-induced aging. This is the first study to evaluate the serum and follicular fluid (FF) thiol/disulfide homeostasis in patients under 35 years of age with DOR undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).
Methods: In this study, DOR was defined by the Poseidon criteria, and Poseidon group 3 women were selected as the study group (n = 40). The control group was composed of patients with the diagnosis of mild-moderate male factor infertility (n = 30).
Results: The FF and serum native and total thiol levels, the markers of the antioxidant system, were significantly decreased in the DOR group compared with the control group (p = 0.021) (p = 0.037) (p = 0.029) (p = 0.04). On the other hand, we found no significant differences in the oxidant parameters between the groups (p > 0.05).
Conclusions: An intrinsic deficiency of antioxidants can play an important role in the etiology of DOR. The dietary addition of antioxidants could be beneficial in DOR patients.
This study aimed to investigate the potential increase in pregnancy complications during the pandemic period. Material and Methods: Data of the pregnant women who were admitted between April/May 2019 and April/May 2020 for stillbirth, preterm labor, term prelabor rupture of membranes (PROM), preterm premature rupture of membranes (PPROM), placental abruption, miscarriage and abortion imminens were collected from the hospital database and retrospectively analyzed. Mann-Whitney U test was used to compare continuous variables between the diagnostic groups according in 2019 and 2020. The relationships between the categorical variables were tested by Chi-Square analysis. Results: During the COVID-19 pandemic period between April/May 2020, 1604 deliveries occurred in our hospital. Total 1401 deliveries had occurred in the same monthly interval of 2019. In the early pregnancy unit, 566 patients were admitted to be monitored in 2019 whereas that number is 466 in 2020. In the pandemic period, a statistically significant difference was found between 2019 and 2020 regarding the rates of admission after the 22nd gestational week and admission to the Early Pregnancy Assessment Unit. Bonferroni tests were performed to determine which group of the patients generated this difference and it was determined that the rates of term PROM and miscarriage increased statistically significantly in 2020 compared with 2019.
Conclusion:We concluded that the effect of COVID-19 on symptomatic and asymptomatic pregnant women will be further clarified by switching to a routine screening program for pregnant women in our country. COVID-19 antibody testing is important to confirm our results in the cases with term PROM and miscarriage who are asymptomatic with respect to COVID-19.
Objective:
This study aimed to present the characteristic features of 19 patients who were diagnosed as having Blake’s pouch cyst (BPC) at our center.
Materials and Methods:
Nineteen patients diagnosed as BPC between 2015 and 2019 were included in this retrospective study. Follow-up examinations were performed using ultrasonography (US) every three weeks up to 35 weeks of gestation. Prenatal magnetic resonance imaging (MRI) was performed at the time of diagnosis or during follow-up in 13 patients. MRI or transfontanellar US was performed to confirm the diagnosis of BPC after delivery. Karyotype results of eight patients were recorded.
Results:
Isolated BPC was observed in 9 (47%) patients, and associated anomalies were detected in 10 (53%) patients, including seven (36%) with the central nervous system and four (21%) with cardiac anomalies. Two fetuses had abnormal karyotype analysis as trisomy 21 and 13. The MRI report of eight patients was “differential diagnosis required for Dandy-Walker complex” and only in five (26%) patients, it was reported to be compatible with BPC. Spontaneous resolution was seen in four patients. Postnatal MRI was performed in five patients, and transfontanellar US in two patients, and all MRI and US results were consistent with BPC. During the neonatal period, abnormal neurologic development was observed in four (21%) patients, and one (5%) died.
Conclusion:
Although the prognosis of isolated BPC is very good with healthy neurologic development until advanced ages, death in the early neonatal period and abnormal neurologic development may be observed depending on the condition of the associated anomalies.
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