Effects of curcumin gel on osteoclastogenic bone markers in experimental periodontitis and alveolar bone loss in wistar rats

Abstract

Background/purpose Curcumin has anti-inflammatory impacts and was suggested as an inflammatory disease therapy. This study aimed to investigate the implications of curcumin gel on experimental periodontitis (EPD) and alveolar bone loss in rats. Materials and methods In this study, twenty-four male Wistar rats were divided equally into four groups: negative control (with no EPD); positive control (EPD induced around lower centrals without treatment); control-treated group: EPD treated with chlorhexidine; and test EPD group treated with curcumin. After 30 days, the serum concentrations of RANKL and IL-1β were measured via ELISA. All animals were sacrificed, and mandibular central incisors with the periodontium were removed. The lingual probing depth and radiographical alveolar bone loss were measured, then samples processed for routine preparation of H&E stained sections and histologically assessed for counting inflammatory cells, osteoclasts, and PDL width. Results A significant decrease in the inflammatory cells infiltration, probing depth, and osteoclast numbers with the improvement of PDL associated with a reduction in RANKL and IL-1β serum concentration were seen in both EPD treated groups. Conclusion Curcumin is as effective as chlorhexidine in treating experimental periodontitis in rats. It was demonstrated to stop bone destruction related to periodontitis by regulating the RANKL and IL-1β markers level in the blood.

Enhancing Therapeutic Efficacy of Curcumin: Advances in Delivery Systems and Clinical Applications

“…It has been investigated for the treatment of minor recurrent aphthous stomatitis (RAS) and oral leukoplakia and as an adjunct in endodontic therapy, gingivitis treatment, and oral wound healing. Additionally, curcumin gel shows potential as an adjunctive therapy in periodontal treatment [ 92 , 93 , 94 , 96 , 97 , 99 , 104 , 116 , 117 , 118 ], reducing bone and root resorption during orthodontic treatment and enhancing the efficacy of scaling and root planing (SRP) in treating chronic periodontitis.…”

Antioxidant Effects of Curcumin Gel in Experimental Induced Diabetes and Periodontitis in Rats

“…in an experimental study [ 14 ]. The selection of 12.5 μ g/ml curcumin gel in the current study was based on an experimental study [ 15 , 16 ].…”

“…It possesses antiinflammatory, antioxidant [ 14 ], antimicrobial properties [ 15 ], along with its hepatoprotective, immunostimulant, antiseptic, antimutagenic, and many more properties. In recent years, the use of curcumin extracts has gained popularity, and it has been used as adjunct to SRP to treat periodontitis or repair bone defects [ 16 ].…”

Effect of Curcumin gel on inflammatory and anti-inflammatory biomarkers in experimental induced periodontitis in rats: a biochemical and immunological study

“…All ligatures were checked daily, and if any were missing, they were instantly replaced. Additionally, 0.03 mL (1 × 10 6 CFU/mL) of P. gingivalis was applied every 3 days to the base of the gingival sulcus of the examined tooth (upper left incisor) for a period of 10 days ( Sha et al, 2021 ). The induction of periodontitis confirmed by presence of probing pocket depth >0.5 mm using Williams periodontal probe ( Fischer and Klinge, 1994 ).…”