Effects of crystalline morphology on the tensile properties of electrospun polymer nanofibers

Lim, Chwee Teck; Tan, Eunice X.; Ng, Sun Pui

doi:10.1063/1.2857478

Cited by 240 publications

(225 citation statements)

References 22 publications

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“…SEM micrographs showed that in all cases microfibers had extremely rough surfaces with characteristic transversal striations whereas unloaded nanofibers showed relatively smooth surfaces that became rough with pores when triclosan was incorporated. The texture of microfibers suggests a dense lamellar stacking perpendicular to the fiber axis with amorphous regions between them [18].…”

Section: Results and Discussion 31 Morphology Of Electrospun Polylamentioning

confidence: 99%

Biodegradable polyesters reinforced with triclosan loaded polylactide micro/nanofibers: Properties, release and biocompatibility

Valle¹,

Díaz²,

Royo³

et al. 2012

Express Polym. Lett.

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Abstract. Mechanical properties and drug release behavior were studied for three biodegradable polyester matrices (polycaprolactone, poly(nonamethylene azelate) and the copolymer derived from 1,9-nonanediol and an equimolar mixture of azelaic and pimelic acids) reinforced with polylactide (PLA) fibers. Electrospinning was used to produce suitable mats constituted by fibers of different diameters (i.e. from micro-to nanoscale) and a homogeneous dispersion of a representative hydrophobic drug (i.e. triclosan). Fabrics were prepared by a molding process, which allowed cold crystallization of PLA micro/nanofibers and hot crystallization of the polyester matrices. The orientation of PLA molecules during electrospinning favored the crystallization process, which was slightly enhanced when the diameter decreased. Incorporation of PLA micro/nanofibers led to a significant increase in the elastic modulus and tensile strength, and in general to a decrease in the strain at break. The brittle fracture was clearer when high molecular weight samples with high plastic deformation were employed. Large differences in the release behavior were detected depending on the loading process, fiber diameter size and hydrophobicity of the polyester matrix. The release of samples with the drug only loaded into the reinforcing fibers was initially fast and then became slow and sustained, resulting in longer lasting antimicrobial activity. Biocompatibility of all samples studied was demonstrated by adhesion and proliferation assays using HEp-2 cell cultures.

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Section: Results and Discussion 31 Morphology Of Electrospun Polylamentioning

confidence: 99%

Biodegradable polyesters reinforced with triclosan loaded polylactide micro/nanofibers: Properties, release and biocompatibility

Valle¹,

Díaz²,

Royo³

et al. 2012

Express Polym. Lett.

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“…An interesting work about the effect of crystallinity of PLA microfiber by electrical and centrifugal field on mechanical responses was described by Liao et al [8]. Lim and Tan reported that electrospun polycaprolactone (PCL) nanofibers with smaller diameters had a higher degree of molecular orientation, crystallinity and mechanical properties [9]. In other paper, Tan and Lim reported the effect of annealing on electrospun poly(L-lactic acid) (PLLA) about crystalline structure after electrospinning [10].…”

Section: Introductionmentioning

confidence: 96%

Structure of poly(lactic-acid) PLA nanofibers scaffolds prepared by electrospinning

Gómez-Pachón

Vera‐Graziano

Campos

2014

IOP Conf. Ser.: Mater. Sci. Eng.

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“…40,43 Molecular structure X-ray diffraction is commonly used to determine the crystal structure of polymer fibers. 15,20,42,52 Often after chemical modification or the attachment of functional groups, the molecular structure is determined using FTIR 42,43,85,86 or nuclear magnetic resonance analysis. 52 …”

Section: Drug and Protein Distributionmentioning

confidence: 99%

Polymeric Nanofibers in Tissue Engineering

Dahlin

Kasper

Mikos

2011

Tissue Engineering Part B: Reviews

294

198

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Polymeric nanofibers can be produced using methods such as electrospinning, phase separation, and selfassembly, and the fiber composition, diameter, alignment, degradation, and mechanical properties can be tailored to the intended application. Nanofibers possess unique advantages for tissue engineering. The small diameter closely matches that of extracellular matrix fibers, and the relatively large surface area is beneficial for cell attachment and bioactive factor loading. This review will update the reader on the aspects of nanofiber fabrication and characterization important to tissue engineering, including control of porous structure, cell infiltration, and fiber degradation. Bioactive factor loading will be discussed with specific relevance to tissue engineering. Finally, applications of polymeric nanofibers in the fields of bone, cartilage, ligament and tendon, cardiovascular, and neural tissue engineering will be reviewed.

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Effects of crystalline morphology on the tensile properties of electrospun polymer nanofibers

Cited by 240 publications

References 22 publications

Biodegradable polyesters reinforced with triclosan loaded polylactide micro/nanofibers: Properties, release and biocompatibility

Biodegradable polyesters reinforced with triclosan loaded polylactide micro/nanofibers: Properties, release and biocompatibility

Structure of poly(lactic-acid) PLA nanofibers scaffolds prepared by electrospinning

Polymeric Nanofibers in Tissue Engineering

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