Biodegradable polyesters reinforced with triclosan loaded polylactide micro/nanofibers: Properties, release and biocompatibility

Valle, Luís J. del; Díaz, Angélica; Royo, Míriam; Rodríguez‐Galán, Alfonso; Puiggalı́, Jordi

doi:10.3144/expresspolymlett.2012.30

Cited by 32 publications

(16 citation statements)

References 38 publications

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“…Most of these studies address the possibility of using such nanofibers in filtering, biomedical, sensor and clothing applications [1][2][3][4]. Because of their high surface-area-to-volume ratio, the nanofibrous materials could also be efficient reinforcing materials in polymer matrix composites.…”

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confidence: 99%

The effect of needleless electrospun nanofibrous interleaves on mechanical properties of carbon fabrics/epoxy laminates

Molnár¹,

Ko²,

Mészáros³

2014

Express Polym. Lett.

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The relatively easy production of polymer nanofibers by electrospinning has been the subject of many application-oriented investigations over the past few years. Most of these studies address the possibility of using such nanofibers in filtering, biomedical, sensor and clothing applications [1][2][3][4]. Because of their high surface-area-to-volume ratio, the nanofibrous materials could also be efficient reinforcing materials in polymer matrix composites. In these systems, the nanofibers can even act as the primary reinforcement (the nanofibers are the only reinforcing materials) as well as co-reinforcement (in addition to microfibers) [5]. From a mechanical properties point of view, the main problem associated with common fiber-reinforced polymer composite laminates is their weak interlaminar properties. Due to a geometry that is not absolutely planar, much free space occurs between layers of the reinforcing structures, which are filled up by the matrix material during impregnation. Thus, between the layers, the properties are determined mainly by the matrix and voids. The loads induced by shear-or out-of-plane stresses must be borne by this relatively weak matrix, 62The effect of needleless electrospun nanofibrous interleaves on mechanical properties of carbon fabrics/epoxy laminates Abstract. The effect of polyacrylonitrile nanofibrous interlaminar layers on the impact properties of unidirectional and woven carbon fabric (CF)-reinforced epoxy (EP) matrix composites was investigated. The nanofibers were produced directly on the surface of carbon fabrics by a needleless electrospinning method, and composites were then prepared by vacuum-assisted impregnation. Interlaminar shear stress tests, three-point bending, Charpy-impact and instrumented falling weight tests were carried out. The fracture surfaces were analyzed by scanning electron microscopy. Due to the nano-sized reinforcements, the interlaminar shear strength of the woven and unidirectional fiber-reinforced composites was enhanced by 7 and 11%, respectively. In the case of the falling weight impact tests carried out on woven reinforced composites, the nanofibers increased the absorbed energy to maximum force by 64% compared to that measured for the neat composite. The Charpy impact tests indicated that the nanofiber interleaves also led to a significant increase in the initiation and total break energies. Based on the results, it can be concluded that the presence of nanofibers can effectively increase the impact properties of composites without compromising their in-plane properties because the thickness of the composites was not altered by the presence of interleaves. The improvement of the impact properties can be explained by the good load distribution behavior of the nanofibers.

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confidence: 99%

The effect of needleless electrospun nanofibrous interleaves on mechanical properties of carbon fabrics/epoxy laminates

Molnár¹,

Ko²,

Mészáros³

2014

Express Polym. Lett.

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“…29,30 Nevertheless, PLA concentration also played a determinant role because nanofibers could again be obtained when it was lower than 5% (w/v). 31 The above conclusions were taken into account in this study since a micrometer scale was preferred to detect release differences between drugs and from distinct PLA matrices. The main problem was to choose a solvent based on the chloroform-acetone mixture able to dissolve 10% (w/v) of PLA and the two selected drugs with solubility characteristics different from those of PLA.…”

Section: Resultsmentioning

confidence: 99%

Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs

2015

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Polylactide (PLA) electrospun microfibers were prepared and loaded with triclosan (TCS), ketoprofen (KTP), or their combination to obtain multifunctional scaffolds with bactericide and anti-inflammatory properties. Continuous and porous fibers with diameters in the micrometer scale and a unimodal distribution were successfully attained using a dual-electrospinning technique. Dual drug-loaded scaffolds showed a peculiar release that was in contrast to the single drug-loaded systems, which suggested the establishment of intermolecular interactions that delayed TCS and KTP release. Antimicrobial activity of all TCS-loaded electrospun scaffolds was demonstrated against E. coli and M. luteus bacteria; and furthermore, KTP-loaded samples slightly showed bactericide activity. Biocompatibility of scaffolds was evaluated by adhesion and proliferation assays, and interestingly, the dual drug-load systems were able to support high TCS doses without adverse effects.

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“…diameter of the needle, applied voltage, tip-collector distance and flow rate) [3,[5][6][7][8]. Electrospun micro/nanofibers can also be used as reinforcing materials for biodegradable matrices with low mechanical properties [13][14][15][16][17][18]. This feature appears highly interesting when these weak matrices must be loaded with pharmacological agents since the incorporated drugs usually lead to a significant loss of material properties.…”

Section: Introductionmentioning

confidence: 99%

Poly(ε-caprolactone) films reinforced with chlorhexidine loaded electrospun polylactide microfibers

Lobato¹,

Graupera²,

Valle³

et al. 2017

Express Polym. Lett.

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Poly(ε-caprolactone) (PCL) films reinforced with polylactide (PLA) microfibers were prepared by two methodologies: a) melt pressing of an electrospun PLA mat between two PCL films, and b) melt pressing of a co-electrospun mat composed of PLA microfibers and PCL nanofibers. Electrospinning conditions were selected for each polymer to obtain films loaded with 10, 20 and 30 wt% of PLA. Thermal and mechanical properties varied depending on the preparation method. Thus, PLA crystallinity was higher when films were obtained by the co-electrospinning process, as revealed from DSC and synchrotron X-ray diffraction data since cold crystallization of the highly oriented PLA microfibers was favored in the subsequent heating run when they were in close contact with PCL nanofibers. Samples obtained by co-electrospinning also showed higher mechanical properties (e.g. Young modulus) with increasing PLA load. In this case, fracture surfaces showed significant interactions between fibers and the PCL matrix and decreased fiber pull-out. All fabrics were also loaded with chlorhexidine (CHX) as a hydrophilic bactericide agent. A delayed release was observed when the drug was only loaded into the electrospun PLA microfibers, and diffusion varied with the method of preparation. In all cases, samples had a clear bactericide effect against Gram positive and Gram negative bacteria. Nevertheless, the protective effect was slightly lower when CHX was only loaded in the reinforcing PLA microfibers.

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Biodegradable polyesters reinforced with triclosan loaded polylactide micro/nanofibers: Properties, release and biocompatibility

Cited by 32 publications

References 38 publications

The effect of needleless electrospun nanofibrous interleaves on mechanical properties of carbon fabrics/epoxy laminates

The effect of needleless electrospun nanofibrous interleaves on mechanical properties of carbon fabrics/epoxy laminates

Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs

Poly(ε-caprolactone) films reinforced with chlorhexidine loaded electrospun polylactide microfibers

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