Effects of Croton menyharthii and Uvariodendron kirkii extracts on ovarian corpora lutea and reproductive hormones.

Kaingu, Catherine Kaluwa; Oduma, Jemimah A.; Mbaria, James Mucunu; Kiama, Stephen G.

doi:10.15562/phytomedicine.2017.41

Cited by 3 publications

(3 citation statements)

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“… korupensis are used to cure various conditions ( Jiofack et al 2009 ; Bele et al 2011 ; Bada Amouzoun et al 2019 ) or in Kenya where Ud. kirkii is used as contraceptive ( Kaingu et al 2017 ).…”

Section: Taxonomic Revision Of Dennettia ...mentioning

confidence: 99%

Phylogenomic inference of the African tribe Monodoreae (Annonaceae) and taxonomic revision of Dennettia, Uvariodendron and Uvariopsis

Dagallier,

Mbago,

Couderc

et al. 2023

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Monodoreae (Annonaceae) is a tribe composed of 11 genera and 90 species restricted to the tropical African rain forests. All the genera are taxonomically well circumscribed except the species rich genera Uvariodendron and Uvariopsis which lack a recent taxonomic revision. Here, we used a robust phylogenomic approach, including all the 90 currently accepted species, with several specimens per species, and based on more than 300 Annonaceae-specific nuclear genes, to infer the phylogenetic tree of the Monodoreae and test the limits between the genera and species. We recover all the genera as monophyletic, except the genus Uvariopsis for which the species Uvariopsis tripetala falls outside this clade. We thus reinstate the monotypic genus Dennettia for its single species Dennettia tripetala. We also erect a new tribe, Ophrypetaleae trib. nov., to accommodate the genera Ophrypetalum and Sanrafaelia, as we recover them excluded from the Monodoreae tribe with good support. Below the genus level, the genera Isolona, Monodora, Uvariastrum, Uvariodendron and Uvariopsis show weakly supported nodes and phylogenetic conflicts, suggesting that population level processes of evolution might occur in these clades. Our results also support, at the molecular level, the description of several new species of Uvariodendron and Uvariopsis, as well as several new synonymies. Finally, we present a taxonomic revision of the genera Dennettia, Uvariodendron and Uvariopsis, which contain one, 18 and 17 species respectively. We provide a key to the 11 genera of the Monodoraeae and describe four new species to science: Uvariodendron kimbozaense Dagallier & Couvreur, sp. nov., Uvariodendron mossambicense Robson ex Dagallier & Couvreur, sp. nov., Uvariodendron pilosicarpum Dagallier & Couvreur, sp. nov. and Uvariopsis oligocarpa Dagallier & Couvreur, sp. nov., and provide provisional descriptions of three putatively new species. We also present lectotypifications and nomenclatural changes implying synonymies and new combinations (Uvariodendron citriodorum (Le Thomas) Dagallier & Couvreur, comb. et stat. nov., Uvariodendron fuscum var. magnificum (Verdc.) Dagallier & Couvreur, comb. et stat. nov., Uvariopsis congensis var. angustifolia Dagallier & Couvreur, var. nov., Uvariopsis guineensis var. globiflora (Keay) Dagallier & Couvreur, comb. et stat. nov., and Uvariopsis solheidii var. letestui (Pellegr.) Dagallier & Couvreur, comb. et stat. nov.).

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Section: Taxonomic Revision Of Dennettia ...mentioning

confidence: 99%

Phylogenomic inference of the African tribe Monodoreae (Annonaceae) and taxonomic revision of Dennettia, Uvariodendron and Uvariopsis

Dagallier,

Mbago,

Couderc

et al. 2023

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“…f., and Asteranthe asterias (S. Moore) Engl. & Diels belong to the family Annonaceae and are endemic to Kenya, and Tanzania (EA) [ [28] , [29] , [30] ]. Additionally, three newly described and named endemic threatened species ( Uvariodendron mbagoi Dagallier & Couvreur, Uvariodendron dzomboense Dagallier, Q. Luke & Couvreur, and Uvariodendron schmidtii Q. Luke, Dagallier & Couvreur) have been discovered in the above-aforementioned regions [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Predicting the potential impacts of climate change on the endangered endemic annonaceae species in east africa

Mkala,

Mwanzia,

Nzei

et al. 2023

Heliyon

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“…Acute oral toxicity in Wistar rats and the phytochemical composition of the plant were also studied. Uvariodendron anisatum (Annonaceae) has been recorded to have gynecological benefits in some Kenyan communities' traditional medicine systems [8][9][10]. e current findings from the research provide a platform for validation of the use of the plant in traditional medicine.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Uterotonic Activity, Acute Oral Toxicity, and Phytochemical Composition of Uvariodendron anisatum Verdc. Root Extracts

Muthee

Maitho

Kanja

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Over 80% of cultural societies in low-income countries use plant preparations in traditional medicine with unknown potency and safety profiles. Uvariodendron anisatum root extracts are used by some Kenyan herbalists. However, the claims of the plant to remove retained placenta during birth have remained uninvestigated. Therefore, the current study evaluated its uterotonic activities. Acute toxicity in Wistar rats and the phytochemical composition of the plant were also studied. The plant was collected from Embu County in Kenya. The water and ethanol extracts were prepared by maceration. Uterine strips were isolated from primed mature female Wistar rats and used to study the uterotonic activities of the extracts. De Jalon’s solution and oxytocin were used as negative and positive controls, respectively. Acute oral toxicity studies were done following the OECD 423 guideline and phytochemical screening were based on standard phytochemical procedures. The study met all the approval requirements before commencement. Data obtained from the uterotonic activity were analysed by using GraphPad Prism Version 8.0.1 software and expressed as a percentage increase or decrease of mean as mean ± SEM relative to the controls. The findings of acute oral toxicity were expressed using LD50. Additionally, the phytochemical components of the U. anisatum were tabulated. The uterotonic effect of Uvariodendron anisatum root water extract was higher than that of ethanol extract. A single dose of the Uvariodendron anisatum root water extract at 2000 mg/kg did not cause mortality in the tested Wistar rats. Besides, there were no changes in hematological and biochemical parameters. The extracts did not reveal changes in the gross morphology of the liver, kidney, heart, and lung of the tested Wistar rats. However, the histopathological studies of Uvariodendron anisatum root water extracts exhibited toxicity in the liver, kidney, and lung tissues of Wistar rats at a concentration of 2000 mg/kg. Alkaloids, glycosides, saponins, phytosterols, terpenes, proteins, phenols, and oils were recorded in Uvariodendron anisatum. The findings from this study provided scientific evidence which is useful in validating the use of Uvariodendron anisatum extracts in the stimulation of the uterus during birth.

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Effects of Croton menyharthii and Uvariodendron kirkii extracts on ovarian corpora lutea and reproductive hormones.

Cited by 3 publications

References 0 publications

Phylogenomic inference of the African tribe Monodoreae (Annonaceae) and taxonomic revision of Dennettia, Uvariodendron and Uvariopsis

Phylogenomic inference of the African tribe Monodoreae (Annonaceae) and taxonomic revision of Dennettia, Uvariodendron and Uvariopsis

Predicting the potential impacts of climate change on the endangered endemic annonaceae species in east africa

Evaluation of Uterotonic Activity, Acute Oral Toxicity, and Phytochemical Composition of Uvariodendron anisatum Verdc. Root Extracts

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Effects of Croton menyharthii and Uvariodendron kirkii extracts on ovarian corpora lutea and reproductive hormones.

Cited by 3 publications

References 0 publications

﻿Phylogenomic inference of the African tribe Monodoreae (Annonaceae) and taxonomic revision of Dennettia, Uvariodendron and Uvariopsis

﻿Phylogenomic inference of the African tribe Monodoreae (Annonaceae) and taxonomic revision of Dennettia, Uvariodendron and Uvariopsis

Predicting the potential impacts of climate change on the endangered endemic annonaceae species in east africa

Evaluation of Uterotonic Activity, Acute Oral Toxicity, and Phytochemical Composition of Uvariodendron anisatum Verdc. Root Extracts

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Product

Resources

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Phylogenomic inference of the African tribe Monodoreae (Annonaceae) and taxonomic revision of Dennettia, Uvariodendron and Uvariopsis

Phylogenomic inference of the African tribe Monodoreae (Annonaceae) and taxonomic revision of Dennettia, Uvariodendron and Uvariopsis