Effects of Cortical Bone Perforation on Periosteal Distraction: An Experimental Study in the Rabbit Mandible

Oda, Tetsuya; Kinoshita, K; Ueda, Minoru

doi:10.1016/j.joms.2008.06.085

Cited by 42 publications

(51 citation statements)

References 28 publications

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“…22,23 New bone would possibly be more calcified by decortication of the original bone. 17 This was, however, not performed as it might have overridden the effect of the periosteum stimulation alone.…”

Section: Discussionmentioning

confidence: 99%

Comparison of two protocols of periosteal distraction osteogenesis in a rabbit calvaria model

et al. 2015

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The regenerative pathways during periosteal distraction osteogenesis may be influenced by the local environment composed by cells, growth factors, nutrition and mechanical load. The aim of the present study was to evaluate the influence of two protocols of periosteal distraction on bone formation. Custom made distraction devices were surgically fixed onto the calvariae of 60 rabbits.After an initial healing period of 7 days, two groups of animals were submitted to distraction rates of 0.25 and 0.5 mm/24h for 10 days, respectively. Six animals per group were sacrificed 10 (middistraction), 17 (end-distraction), 24 (1-week consolidation), 31 (2-week consolidation) and 77 days (2-month consolidation) after surgery. Newly formed bone was assessed by means of micro-CT and histologically. Expression of transcripts encoding tissue-specific genes (BMP-2, RUNX2, ACP5, SPARC, collagen I α1, collagen II α1 and SOX9) was analyzed by quantitative PCR. Two patterns of bone formation were observed, originating from the old bone surface in Group I and from the periosteum in Group II. Bone volume and bone mineral density significantly increased up to the 2-month consolidation period within the groups (p <0.05). Significantly more bone was observed in Group II compared to Group I at the 2-month consolidation period (p <0.001). Expression of transcripts encoding osteogenic genes in bone depended on the time-point of observation (p <0.05).Low level of transcripts reveals an indirect role of periosteum in the osteogenic process. Two protocols of periosteal distraction in the present model resulted in moderate differences in terms of bone formation.

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Section: Discussionmentioning

confidence: 99%

Comparison of two protocols of periosteal distraction osteogenesis in a rabbit calvaria model

et al. 2015

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“…9 The significance of differences between histomorphometric and radiodensitometric tests were assessed using the Mann-Witney U test. Probabilities of less than 0.05 were accepted as significant.…”

Section: Discussionmentioning

confidence: 99%

“…Only animal studies have been published, to our knowledge, and different devices have been proposed. 1,2,8,9,18 Previously-described distractors required incisions on the periosteum to adapt and secure the device in position or to allow a distraction rod to perforate the flap. However, damage to the periosteum impairs the distraction, 8,18 so it is important to keep the periosteum intact while the device is being inserted.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7] Various techniques of distraction osteogenesis have been described with reasonable success rates, and in recent years the idea of osteogenesis by periosteal distraction for the treatment of bone deficiencies has also been suggested. 1,2,8,9 The highly vascularised internal osteoblastic layer of periosteum plays a part in distraction osteogenesis. It is composed of mesencymal stem cells, 5 and it has therefore been suggested that it is more important than endosteum in distraction osteogenesis.…”

Section: Introductionmentioning

confidence: 99%

“…It is composed of mesencymal stem cells, 5 and it has therefore been suggested that it is more important than endosteum in distraction osteogenesis. 9,10 Statins are effective lipid-lowering drugs that are widely used to reduce the risk of cardiovascular disease given their ability to inhibit the 3-hydroxy-3-methylglutarylcoenzyme. 11 They are extensively bound to plasma proteins and predominantly metabolised by the cytochrome P450 family of enzymes, and their main route of elimination is through bile after being metabolised by the liver.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of local simvastatin on periosteal distraction osteogenesis in rabbits

Kahraman

Özgür

Namli

et al. 2015

British Journal of Oral and Maxillofacial Surgery

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Peri‐Implant Bone Augmentation by the Sub‐Periosteal Peri‐Implant Augmented Layer Technique and a Bovine‐Derived Bone Block: A Case Report

Trombelli

Severi

Ortensi

et al. 2021

Clin Adv Periodontics

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Background: When used with deproteinized bovine bone mineral (DBBM) delivered as a particulate, the subperiosteal peri-implant augmented layer (SPAL) technique was effective in completely correcting up to 92% of peri-implant buccal bone dehiscences. The use of a DBBM block (bDBBM), however, may result in an improvement of the peri-implant bone dehiscence as well as a relevant lateral bone augmentation since its mechanical properties may ensure a better dimensional stability at flap manipulation than particulate DBBM. The aim of the present a proof-of-principle case report is to investigate if SPAL may be successfully used to obtain bone augmentation at peri-implant dehiscence sites when used with bDBBM.Case presentation: Lateral bone augmentation was performed using the SPAL technique at two implants showing a buccal peri-implant bone dehiscence immediately after their placement. A partial-thickness flap was elevated, leaving the periosteal layer on the buccal cortical bone plate. The periosteal layer was, in turn, elevated to create a pouch, which was used to stabilize a bDBBM graft at the peri-implant buccal bone dehiscences. At re-entry, exposed implant surfaces were completely covered by new thick hard tissue up to their most coronal portion. A free epithelial-connective tissue graft was used to augment the peri-implant soft tissue phenotype. Conclusion:When used to accommodate bDBBM over the most coronal portion of an exposed implant, SPAL may successfully lead to an increase in peri-implant buccal tissue thickness. Clin Adv Periodontics 2021;0:1-6.

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Effects of Cortical Bone Perforation on Periosteal Distraction: An Experimental Study in the Rabbit Mandible

Cited by 42 publications

References 28 publications

Comparison of two protocols of periosteal distraction osteogenesis in a rabbit calvaria model

Comparison of two protocols of periosteal distraction osteogenesis in a rabbit calvaria model

Effects of local simvastatin on periosteal distraction osteogenesis in rabbits

Peri‐Implant Bone Augmentation by the Sub‐Periosteal Peri‐Implant Augmented Layer Technique and a Bovine‐Derived Bone Block: A Case Report

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