Effects of local simvastatin on periosteal distraction osteogenesis in rabbits

Kahraman, Onur Evren; Özgür, Erdoğan; Namli, Halide; Sencar, Leman

doi:10.1016/j.bjoms.2015.01.006

Cited by 6 publications

(4 citation statements)

References 23 publications

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“…However, the ideal simvastatin dose and carrier for periosteal distraction have not been fully investigated. Kahraman, Erdogan, Namli and Sencar () loaded 2.5 mg/ml simvastatin on a gelatin sponge and applied it to a titanium periosteal distractor on rabbit mandibles, and simvastatin made no statistically significant contribution to more bone formation. The authors explained that the fast dissolution of the carrier and uncontrolled simvastatin release might be the reason.…”

Section: Discussionmentioning

confidence: 99%

Injectable simvastatin gel for minimally invasive periosteal distraction: In vitro and in vivo studies in rat

Jia

Chou

Kuroda

et al. 2017

Clinical Oral Implants Res

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Section: Discussionmentioning

confidence: 99%

Injectable simvastatin gel for minimally invasive periosteal distraction: In vitro and in vivo studies in rat

Jia

Chou

Kuroda

et al. 2017

Clinical Oral Implants Res

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“…Based on titles and abstracts, 31 studies were selected. Finally, after reading full text and applying study criteria, 24 studies [2,[4][5][6][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] were included in the review (inter-reviewer agreement k = 0.96). The 24 studies selected involved 481 patients with 482 devices.…”

Section: Resultsmentioning

confidence: 99%

Systematic Review and Quality Evaluation Using ARRIVE 2.0 Guidelines on Animal Models Used for Periosteal Distraction Osteogenesis

García-González

Muñoz

González‐Cantalapiedra

et al. 2021

Animals

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The objective of this systematic review was to synthesize all the preclinical studies carried out in periosteal distraction osteogenesis (PDO) in order to evaluate the quality using the ARRIVE guidelines. The animal models used, and the influence of the complications, were analysed in order to establish the most appropriate models for this technique. The PRISMA statements have been followed. Bibliographic sources have been consulted manually by two reviewers. Risk of bias was evaluated using the SYRCLE tool for animal studies, and the quality of the studies with the ARRIVE 2.0 guidelines. The selection criteria established by expert researchers were applied to decide which studies should be included in the review, that resulted in twenty-four studies. Only one achieved the maximum score according to the ARRIVE 2.0 guidelines. The rabbit as an animal model has presented good results in PDO, both for calvaria and jaw. Rats have shown good results for PDO in calvaria. The minipig should not be recommended as an animal model in PDO. Despite the increase in the quality of the studies since the implementation of the ARRIVE 2.0 guidelines, it would be necessary to improve the quality of the studies to facilitate the transparency, comparison, and reproducibility of future works.

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“…HPO therapy could improve the oxygen partial pressure in the blood and tissues, which could promote the synthesis of bone [52]. Kahraman et al [34] made a local application of simvastatin when implanted distraction device, but there was not enough evidence to show that the use of lipid-lowering agents can promote the formation of new bone in PDO.…”

Section: Measures To Promote the Formation Of New Bone In Pdomentioning

confidence: 99%

Periosteal Distraction Osteogenesis: An Effective Method for Bone Regeneration

Zhao

Wang

Han

2016

BioMed Research International

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The treatment of bone defects is challenging and controversial. As a new technology, periosteal distraction osteogenesis (PDO) uses the osteogenicity of periosteum, which creates an artificial space between the bone surface and periosteum to generate new bone by gradually expanding the periosteum with no need for corticotomy. Using the newly formed bone of PDO to treat bone defects is effective, which can not only avoid the occurrence of immune-related complications, but also solve the problem of insufficient donor. This review elucidates the availability of PDO in the aspects of mechanisms, devices, strategies, and measures. Moreover, we also focus on the future prospects of PDO and hope that PDO will be applied to the clinical treatment of bone defects in the future.

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Effects of local simvastatin on periosteal distraction osteogenesis in rabbits

Cited by 6 publications

References 23 publications

Injectable simvastatin gel for minimally invasive periosteal distraction: In vitro and in vivo studies in rat

Injectable simvastatin gel for minimally invasive periosteal distraction: In vitro and in vivo studies in rat

Systematic Review and Quality Evaluation Using ARRIVE 2.0 Guidelines on Animal Models Used for Periosteal Distraction Osteogenesis

Periosteal Distraction Osteogenesis: An Effective Method for Bone Regeneration

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