Effects of Consumptionof a Milk Fermented by the Probiotic Strain Bifidobacterium animalis DN-173 010 on Colonic Transit Times in Healthy Humans

Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women

“…Stool frequency was also significantly improved after product consumption in IBS subjects compared to controls with respect to subjects with a stool frequency < 4 stools per week at baseline [18] . A fifth study performed on fermented milk containing B. lactis DN-173010 alone also demonstrated a reduced transit time in healthy men and women with slow transit time [19] . Our finding that probiotics may normalize bowel movements is in line with those in some previous studies [27][28][29][30] .…”

“…An increase in stool frequency was also observed in subjects with the lowest stool frequency (< 3 or 4 bowel movements/wk) without any change of stool consistency. A fifth study performed on fermented milk containing B. lactis DN-173010 alone also demonstrated a reduced transit time in healthy men and women [19] . The results of these five studies support a strong link between improved stool frequency and the strain B. lactis DN-173010, and indicate that further research should be carried out to investigate the potential use of this fermented milk product for improving stool parameters in subjects with constipation.…”

Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN‐173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation

“…27 Thus modification of the intestinal microflora might potentially alter motility and there is evidence from both animal and human studies to support this view. [28][29][30][31][32][33][34] Probiotics are the centre of considerable interest in relation to the treatment of IBS, although it is important to emphasize that different strains may not necessarily share the same activity. 35,36 Consequently, if a particular probiotic had the potential to accelerate intestinal transit, it is possible that it might help ameliorate the problem of distension associated with IBS.…”

“…35,36 Consequently, if a particular probiotic had the potential to accelerate intestinal transit, it is possible that it might help ameliorate the problem of distension associated with IBS. It is therefore noteworthy that there is some preliminary evidence that the fermented dairy product containing Bifidobacterium lactis DN-173 010 together with two classical yogurt starters can accelerate gastrointestinal transit in healthy volunteers, especially in those with slower transit [30][31][32][33] and subjectively improve the symptoms of bloating and digestive discomfort in patients with IBS-C. 37 To date, there has been no study to evaluate the effect of accelerating intestinal transit on abdominal distension or the potential for a probiotic to achieve this goal. It was the purpose of this investigation to assess the effect of the fermented dairy product containing Bifidobacterium lactis DN-173 010 on distension as measured objectively by AIP as well as recording bloating, transit and other IBS symptoms.…”

Probiotics and intestinal health effects: a clinical perspective

“…However, these studies were not controlled. Two RCT showed that a milk fermented by Bifidobacterium animalis strain DN-173 010 shortened colonic transit time in healthy women (Bouvier et al 2001;Marteau et al 2002). This was also observed in elderly subjects (Méance et al 2002).…”