Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women

Abstract

AIM:To investigate the effect of a fermented milk containing Bifidobacterium lactis DN-173010 and yogurt strains (BIO ® ) on adult women with constipation in Beijing. METHODS: A total of 135 adult females with constipation were randomly allocated to consume for 2 wk either 100 g of the test fermented milk or 100 g of an acidified milk containing non-living bacteria (control). Stool frequency, defecation condition scores, stool consistency and food intake were recorded at baseline and after 1 and 2 wk in an intention-totreat population of 126 subjects. In parallel, safety evaluation parameters were performed. RESULTS: At baseline, no differences were found between groups. Following consumption of test product, stool frequency was significantly increased after 1 wk (3.5 ± 1.5 vs 2.4 ± 0.6, P < 0.01) and 2 wk (4.1 ± 1.7 vs 2.4 ± 0.6, P < 0.01), vs baseline. Similarly, after 1 and 2 wk, of test product consumption, defecation condition (1.1 ± 0.9 vs 1.9 ± 1.2, P < 0.01 and 0.8 ± 1.0 vs 1.9 ± 1.2, P < 0.01, respectively) and stool consistency (1.0 ± 0.8 vs 1.5 ± 1.1, P < 0.01 and 0.6 ± 0.8 vs 1.5 ± 1.1, P < 0.01, respectively) were significantly improved.Compared with the control group, stool frequency was also significantly increased (3.5 ± 1.5 vs 2.5 ± 0.9, P < 0.01 and 4.1 ± 1.7 vs 2.6 ± 1.0, P < 0.01, respectively), and defecation condition (1.1 ± 0.9 vs 1.6 ± 1.1, P < 0.01 and 0.8 ± 1.0 vs 1.6 ± 1.1, P < 0.01, respectively) and stool consistency (1.0 ± 0.8 vs 1.4 ± 1.0, P < 0.05 and 0.6 ± 0.8 vs 1.3 ± 1.0, P < 0.01, respectively) significantly decreased after 1 and 2 wk of product consumption. During the same period, food intake did not change between the two groups, and safety parameters of the subjects were within normal ranges. CONCLUSION: This study suggests a beneficial effect of a fermented milk containing B. lactis DN-173010 on stool frequency, defecation condition and stool consistency in adult women with constipation constipated women after 1 and 2 wk of consumption.

Effects of a kefir supplement on symptoms, colonic transit, and bowel satisfaction score in patients with chronic constipation: A pilot study

“…Three randomized controlled trials (RCT) thus far are available in the pertinent literature regarding the use of probiotics in adults for the treatment of chronic constipation (8)(9)(10). In the first study, Möllenbrink and Bruckschen (8) treated 70 constipated patients with E. coli Nissle 1917 or placebo.…”

“…Growing evidence suggests that probiotics may contribute to ameliorating the symptoms of functional constipation (8)(9)(10).…”

“…efit on the host. There has been growing evidence (8)(9)(10)(11) suggesting that probiotics may have a beneficial role in alleviating constipation symptoms in the adult and pediatric populations, at least with certain strains. Kefir is a fermented beverage originating from the Caucasian regions composed of a number of bacteria and yeasts living together in the polysaccharide grains secreted they secrete.…”

Effects of Bifidobacterium breve on inflammatory gene expression in neonatal and weaning rat intestine

“…Lactic acid bacteria, such as lactobacilli and bifidobacteria, are among the best-known candidates for probiotics. In numerous human trials, although the precise mechanisms have not been determined, intake of lactobacilli and bifidobacteria has been reported to be beneficial with respect to stool frequency and stool consistency (2,3). The potential benefit of probiotics in the modulation and regulation of the immune response has also been reported in both humans and animals (4)(5)(6)(7)(8).…”

“…Gene expression in the rat colon, small intestine, and spleen was examined by microarray and real-time PCR after feeding 5 × 10 8 colony-forming units/animal B. breve to rat pups during the newborn (days [1][2][3][4][5][6][7][8][9][10][11][12][13][14] or weaning (days 21-34) period.…”