Effects of compression on soft tissue optical properties

Chan, Eric K.; Sorg, Brian S.; Protsenko, Dmitriy E.; O’Neil, Michael; Motamedi, Massoud; Welch, Ashley J.

doi:10.1109/2944.577320

Cited by 221 publications

(190 citation statements)

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“…Jacques et al [29] reported a reduction in the volumetric fraction of melanosomes proportional to the reduction in epidermal thickness; that is a 23% reduction at 2.4 kP a suction pressure (which seems too small of a suction pressure for such a reduction, perhaps a typographical error in the reported value of pressure). Chan et al [30] measured in vitro changes in optical properties of pig and human skin slabs as a function of compression load; there was an increase in transmittance, absorption, and scattering coefficients and a reduction in reflectance among most of the compressed specimens which the authors attributed the effects to changes in shape of cellular components, reduction in index-mismatch and changes in scatterer and chromophore concentrations. As the VRS results show in Figure 11, there were significant reductions in m a,e observed from the application of P v .…”

Section: Discussionmentioning

confidence: 99%

Laser surgery of port wine stains using local vacuum pressure: Changes in skin morphology and optical properties (Part I)

et al. 2007

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Background and Objectives: In a recent case study, the use of a suction device to aid in port wine stain (PWS) laser treatments showed favorable results. It is our objective to further understand the mechanisms of vacuum-assisted laser therapy by analyzing the mechanical and optical changes of the skin and musculoskeletal tissues during the application of mild vacuum pressure from a suction cup. Study Design/Materials and Methods: A mathematical model of tissue deformation was used to determine the changes in tissue morphology that affect the underlying laser-tissue interactions, such as epidermal stretching and thinning, blood vessel dilation, and change in blood vessel depth. Video imaging experiments were used to verify the bulk tissue deformation and skin surface stretching computed by the mathematical model. Additionally, visible reflectance spectroscopy was used to determine the changes in the optical characteristics of tissue, including blood vessel dilation and epidermal absorption coefficient. Results: At a vacuum pressure of 50 kP a , the epidermis at the center of the suction cup was measured to stretch 4% and was calculated to be thinned approximately 6%. Blood vessels embedded in the dermis were measured to dilate up to two times their original size. However, these vessels were calculated to be displaced toward the skin surface by a very small amount, approximately 1-3 mm. The absorption coefficient of the epidermis was also measured to be reduced significantly by approximately 25% at a wavelength of 585 nm. Conclusions: Mild vacuum pressure applied to the skin surface causes considerable changes in the morphology and optical properties of the tissue. These changes may be used for more efficient photothermolysis of small PWS blood vessels.

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Section: Discussionmentioning

confidence: 99%

Laser surgery of port wine stains using local vacuum pressure: Changes in skin morphology and optical properties (Part I)

et al. 2007

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“…Thus, in Ref. [174] the studies of compression of soft tissue samples demonstrated the growth of the transmission coefficient and the reduction of the diffuse reflection coefficient in the spectral region from 400 to 1800 nm. It was concluded that the compression increases the coefficients of absorption and scattering of the tissue, and the possible mechanisms of the "clearing" are the reduction of the sample thickness and its dehydration.…”

Section: Compression Clearingmentioning

confidence: 99%

“…The first studies [174,175] were carried out with the tissue samples ex vivo. The authors noticed that the external compression changed the optical properties of the tissue samples, which manifested itself in the change of diffuse reflection and transmission of light by the samples of tissues.…”

Section: Compression Clearingmentioning

confidence: 99%

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Genina

Bashkatov

Sinichkin

et al. 2015

JBPE

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Abstract.A review of specific features and methods of optical clearing and related interaction of light with tissues is presented. Physical and molecular mechanisms of immersion, compression, and photodynamic/photothermal optical clearing of some fibrous and cellular tissues are discussed. The possibility of efficient control of the tissue optical properties, particularly, the reduction of light scattering in tissues is demonstrated, which facilitates the increased efficiency of various optical visualisation methods (optical biopsy) used in medical purposes. © 2015 Samara State Aerospace University (SSAU).Keywords: tissue, optical clearing, optical diagnostics, imaging. 1, 404-413 (1997). 5. C. L. Smithpeter, A. K. Dunn, A. J. Welch, and R. Richards-Kortum, "Penetration depth limits of in vivo confocal reflectance imaging," Appl. Opt. 37, 2749Opt. 37, -2754Opt. 37, (1998. 6. V. V. Tuchin, L. V. Wang, and D. A. Zimnyakov, Optical Polarization in Biomedical Applications, SpringerVerlag, New York, NY, USA (2006). 7. R. Drezek, A. Dunn, and R. Richards-Kortum, "Light scattering from cells: finite-difference time-domain simulations and goniometric measurements," Appl. Opt. 38(16), 3651-3661 (1999). 8. K. Sokolov, R. Drezek, K. Gossagee, and R. Richards-Kortum, "Reflectance spectroscopy with polarized light:is it sensitive to cellular and nuclear morphology," Opt. Express 5, 302-317 (1999). 9. D. W. Leonard, and K. M. Meek, "Refractive indices of the collagen fibrils and extrafibrillar material of the corneal stroma," Biophysical J. 72, 1382-1387 (1997). 10. A. G. Borovoi, E. I. Naats, and U. G. Oppel, "Scattering of light by a red blood cell," J. Biomed. Opt. 3, 364-372 (1998). 11. A. N. Yaroslavsky, A. V. Priezzhev, J. Rodriguez, I. V. Yaroslavsky, and H. Battarbee, "Optics of blood,"Chap. 2 in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, Ed., pp. 169-216, PM107 SPIE Press, Bellingham, WA, USA (2002). 12. G. Mazarevica, T. Freivalds, and A. Jurka, "Properties of erythrocyte light refraction in diabetic patients," J.Biomed. Opt. 7, 244-247 (2002). 13. M. Friebel, and M. Meinke, "Model function to calculate the refractive index of native hemoglobin in the wavelength range of 250-1100 nm dependent on concentration," Appl. Opt. 45(12), 2838-2842 (2006). Appl. Opt. 35(19), 3413-3420 (1996). 34. D. Zhu, J. Wang, Z. Zhi, X. Wen, and Q. Luo, "Imaging dermal blood flow through the intact rat skin with an optical clearing method," J. Biomed. Opt. 15, 026008 (2010 241. K. König, G. Flemming, and R. Hibst, "Laser-induced autofluorescence spectroscopy of dental caries lesion," Cell. Mol. Biol. 44, 1293-1300. 242. E. G. Borisova, T. T. Uzunov, and L. A. Avramov, "Early differentiation between caries and tooth demineralization using laser-induced autofluorescence spectroscopy," Lasers Surg. Med. 34, 249-253 (2004 -20(12), 1512-1516 (1984). 245. K. Konig, H. Schneckenburger, and R. Hibst, "Time-gated in vivo autofluorescence imaging of dental caries,"Cell. Mol. Biol. 45, 233-239 (1999). 246. E. Borisova, P. Tr...

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“…Esta influencia es mucho más importante que los cambios que se producen cuando se irradian distintas zonas de un mismo individuo o individuos de distintas razas (salvo casos extremos: palma de la mano y antebrazo en el caso de afroamericanos, o distintas razas). Debemos notar que la dispersión de valores medidos de los coeficientes de absorción y esparcimiento en una misma raza es muy grande [23][24][25][26][27] . Por ejemplo, Chan et al 27 obtienen valores de fi a entre 0,2 y 1,3 cm 1 y valores de ¡i s entre 6,9 y 19,6crrr 1 para 6 individuos caucásicos.…”

Section: Resultados Y Discusiónunclassified

Terapia por láser de baja potencia: consideraciones óptico-físicas y biológicas determinantes en su aplicación clínica

Quintero¹,

Sande

Arroyo

2011

Fisioterapia

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ResumenObjetivos: Analizar la distribución de energía en un tejido cuando se emplea terapia por láser de baja potencia y estudiar las especificaciones mínimas de equipos de terapia láser para estimar la dosis. Material y métodos: Se ha empleado el método de Monte Cario para obtener la distribución de energía absorbida por la piel para dos tipos de láser y la teoría de la difusión para estimar la longitud de penetración y el recorrido libre medio. Se ha estudiado la variación de esa distribución en función de la raza (caucásico, asiático, afroamericano) y para dos localizaciones anatómicas distintas. Se ha analizado la información facilitada por diversos fabricantes de equipos comerciales para determinar si es necesario adaptar la dosimetría recomendada. Resultados: La radiación láser infrarroja (810nm) se absorbe mayoritariamente en un espesor de piel de 1,9±0,2mm para caucásicos, entre 1,73±0,08mm (volar del antebrazo) y 1,80±0,11mm (palma) para asiáticos y entre 1,25±0,09mm (volar del antebrazo) y 1,65 ±0,2 mm (palma) para afroamericanos. El recorrido libre medio de la luz siempre es menor que 0,69 ±0,09 mm. Para los equipos comerciales analizados la única característica geométrica del haz láser que se menciona es la superficie que oscila entre 0,08 y 1 cm 2 , pero no se especifica cómo es la distribución de energía, la divergencia del haz, forma de la sección transversal, etc.Conclusiones: Dependiendo del equipo de terapia por láser de baja potencia utilizado, el tipo de paciente y la zona a tratar, el clínico debe adaptar las dosis recomendadas.

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Effects of compression on soft tissue optical properties

Cited by 221 publications

References 10 publications

Laser surgery of port wine stains using local vacuum pressure: Changes in skin morphology and optical properties (Part I)

Laser surgery of port wine stains using local vacuum pressure: Changes in skin morphology and optical properties (Part I)

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Terapia por láser de baja potencia: consideraciones óptico-físicas y biológicas determinantes en su aplicación clínica

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