Effects of citicoline on experimental spinal cord injury

The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males

“…Similar to animal studies that support the use of low doses of citicoline (Cakir et al, 2005; Diederich et al, 2012), the current study demonstrates measurable effects in human populations using a relatively small dose of citicoline (250 up to 500 mg/day or up to approximately 6.6 mg/kg for an average adult) compared with amounts commonly used in clinical trials (1,000 mg/day or roughly 13.2 mg/kg for an average adult; Pawar et al, 2014). Specifically, this study provides behavioral evidence from between-group analyses as well as weight-adjusted dose analyses for improved frontal lobe function with low doses of citicoline, as reflected in enhanced attentional abilities.…”

“…Animal studies of stroke and traumatic brain injury in rats have found significantly improved motor function shortly after exogenous administration of 100 mg/kg (Diederich et al, 2012) and 300 mg/kg of citicoline (Cakir et al, 2005). In addition, a study by Drago and colleagues (1993) demonstrated improved motor capacity and coordination after supplementation of 10 to 20 mg/kg/day for 20 days in rats bred for cognitive and motor deficits, as well as in rats with drug-induced behavioral changes.…”

Effect of repeatedly given CDP-choline on cardiovascular and tissue injury in spinal shock conditions: investigation of the acute phase

“…Furthermore, the SOD levels remained the same on day 1 while GSHPx activity increased significantly. Conversely, we did not observe any change in plasma and tissue MDA levels, which is not consistent with some of the previous reports that demonstrated the increase in spinal tissue MDA levels 24 or 48 h after spinal cord trauma [32,33] . In contrast to previous studies, however, we have used the transection method instead of the weight dropped trauma model.…”

Palm vitamin E reduces locomotor dysfunction and morphological changes induced by spinal cord injury and protects against oxidative damage

“…Antiserum inhibitor of nitric oxide synthesis 12 , Nitro steroid NCX 1015 48 intra-peritoneal (IP) citocholine 49 and Curcumin 50 because of their antioxidant effect, are able to reduce SCI following by trauma. However, many promising attempts have been made to reduce the signs of SCI, but none have yielded reliable effects.…”