The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males

McGlade, Erin; Agoston, Anna Monica; DiMuzio, Jennifer; Kizaki, Miho; Nakazaki, Eri; Kamiya, Toshikazu; Yurgelun‐Todd, Deborah

doi:10.1177/1087054715593633

Cited by 16 publications

(16 citation statements)

References 38 publications

(57 reference statements)

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“…Compared to the start of the research, the citicoline users achieved significantly better results both in CPT-II detectability and CPT-II commission error ( p = 0.03 and p = 0.01, respectively). Citicoline supplementation was linked with motor function enhancement, attention betterment, and impulsiveness reduction among test subjects [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

Application of Citicoline in Neurological Disorders: A Systematic Review

et al. 2020

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Citicoline is a chemical compound involved in the synthesis of cell membranes. It also has other, not yet explained functions. Research on the use of citicoline is conducted in neurology, ophthalmology, and psychiatry. Citicoline is widely available as a dietary supplement. It is often used to enhance cognitive functions. In our article, accessible databases were searched for articles regarding citicoline use in neurological diseases. This article has a systemic review form. After rejecting non-eligible reports, 47 remaining articles were reviewed. The review found that citicoline has been proven to be a useful compound in preventing dementia progression. It also enhances cognitive functions among healthy individuals and improves prognosis after stroke. In an animal model of nerve damage and neuropathy, citicoline stimulated regeneration and lessened pain. Among patients who underwent brain trauma, citicoline has an unclear clinical effect. Citicoline has a wide range of effects and could be an essential substance in the treatment of many neurological diseases. Its positive impact on learning and cognitive functions among the healthy population is also worth noting.

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Section: Resultsmentioning

confidence: 99%

Application of Citicoline in Neurological Disorders: A Systematic Review

et al. 2020

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“…Citicoline stimulates phosphatidylcholine synthesis in the brain [210][211][212][213] and improves the energetic cerebral metabolism of elderly subjects [214]; a fact that is correlated to an improvement on cognitive capacities [215][216][217][218][219]. In healthy volunteers, the administration of citicoline has been associated with improvement in attention [220,221], memory [222,223] and in some neurophysiological parameters [224][225][226][227].…”

Section: Clinical Studiesmentioning

confidence: 99%

Citicoline in the Treatment of Cognitive Impairment

Secades¹

2019

J Neurol Exp Neurosci

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Vascular cognitive impairment is a process which is more frequent in patients with cardiovascular risk factors. The etiology of this kind of impairment could be related to different types of cerebrovascular disorders, given that silent cerebral infarctions or microinfarcts, correlated with small vessel disease, are one of the principal etiologies. Microinfarcts, associated with small vessel diseases, should be considered one of the possible causes of clinical suspicion in patients with cardiovascular risk factors who are asking for help for cognitive complaints. Among the proposed treatments for cognitive impairment there is citicoline. This is an updated review of the possible use of citicoline in the treatment of cognitive impairment.

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“…However, trials in which the effects of oral supplementation of humans with choline or phosphatidylcholine on cognition were investigated yielded mixed, mostly negative results (see [45] and references cited therein). On the other hand, in a recent small placebo-controlled study, adolescent males treated with citicoline showed improved attention and psychomotor speed and reduced impulsivity [46]. In other recent controlled studies, citicoline seemed to be efficacious in adult patients suffering from cognitive impairments, especially of vascular origin [47].…”

Section: Citicoline: a “Procognitive” Form Of Cholinementioning

confidence: 99%

Citicoline: A Superior Form of Choline?

Synoradzki

Grieb

2019

Nutrients

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Medicines containing citicoline (cytidine-diphosphocholine) as an active principle have been marketed since the 1970s as nootropic and psychostimulant drugs available on prescription. Recently, the inner salt variant of this substance was pronounced a food ingredient in the major world markets. However, in the EU no nutrition or health claim has been authorized for use in commercial communications concerning its properties. Citicoline is considered a dietetic source of choline and cytidine. Cytidine does not have any health claim authorized either, but there are claims authorized for choline, concerning its contribution to normal lipid metabolism, maintenance of normal liver function, and normal homocysteine metabolism. The applicability of these claims to citicoline is discussed, leading to the conclusion that the issue is not a trivial one. Intriguing data, showing that on a molar mass basis citicoline is significantly less toxic than choline, are also analyzed. It is hypothesized that, compared to choline moiety in other dietary sources such as phosphatidylcholine, choline in citicoline is less prone to conversion to trimethylamine (TMA) and its putative atherogenic N-oxide (TMAO). Epidemiological studies have suggested that choline supplementation may improve cognitive performance, and for this application citicoline may be safer and more efficacious.

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The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males

Abstract: Adolescent males receiving 28 days of Cognizin® citicoline showed improved attention and psychomotor speed and reduced impulsivity compared to adolescent males who received placebo.

Cited by 16 publications

References 38 publications

Application of Citicoline in Neurological Disorders: A Systematic Review

Application of Citicoline in Neurological Disorders: A Systematic Review

Citicoline in the Treatment of Cognitive Impairment

Citicoline: A Superior Form of Choline?

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