Effects of chronic gamma irradiation: a multigenerational study using Caenorhabditis elegans

Buisset-Goussen, Adeline; Goussen, Benoit; Della-Vedova, Claire; Galas, Simon; Adam-Guillermin, Christelle; Lecomte-Pradines, Catherine

doi:10.1016/j.jenvrad.2014.07.014

Cited by 48 publications

(52 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After chronic irradiation, a recent study of our team has shown that reproduction is the more sensitive macroscopic parameter regarding survival and growth [17]. Moreover, our first study has also highlighted that, contrary to acute irradiation, chronic irradiation from 3.3 Gy induced a decrease of the number of progeny without impacting the hatching success [4].…”

Section: Introductionmentioning

confidence: 65%

“…The free living nematode Caenorhabditis elegans is a particularly convenient model organism to address this environmental risk assessment based proteomic issue [14,15]. With its fully sequenced genome and its short life cycle, C. elegans has been successfully used to study acute and chronic irradiation effects and their consequences on germline development and hatching [4,[16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Differential modification of the C. elegans proteome in response to acute and chronic gamma radiation: Link with reproduction decline

Dubois

Pophillat

Audebert

et al. 2019

Science of The Total Environment

Self Cite

View full text Add to dashboard Cite

HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Distributed under a Creative Commons Attribution-NonCommercial-NoDerivatives| 4.0 International License

show abstract

Section: Introductionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Differential modification of the C. elegans proteome in response to acute and chronic gamma radiation: Link with reproduction decline

Dubois

Pophillat

Audebert

et al. 2019

Science of The Total Environment

Self Cite

View full text Add to dashboard Cite

show abstract

“…These studies have tended to indicate a persistence of the effects to unexposed generations such as for gold nanoparticles [19] and metals in C. elegans [31], and to some extent for carbon nanotubes in D. magna [31]. In C. elegans, even increased negative effects on individuals after cessation of g-irradiation compared with continuously exposed ones were observed [32]. To our knowledge, none have so far looked at recovery from multigenerational exposure.…”

Section: Discussionmentioning

confidence: 99%

Multigenerational exposure to silver ions and silver nanoparticles reveals heightened sensitivity and epigenetic memory inCaenorhabditis elegans

et al. 2016

View full text Add to dashboard Cite

The effects from multigenerational exposures to engineered nanoparticles (ENPs) in their pristine and transformed states are currently unknown despite such exposures being an increasingly common scenario in natural environments. Here, we examine how exposure over 10 generations affects the sensitivity of the nematode Caenorhabditis elegans to pristine and sulfidized Ag ENPs and AgNO 3 . We also include populations that were initially exposed over six generations but kept unexposed for subsequent four generations to allow recovery from exposure. Toxicity of the different silver forms decreased in the order AgNO 3 , Ag ENPs and Ag 2 S ENPs. Continuous exposure to Ag ENPs and AgNO 3 caused pronounced sensitization (approx. 10-fold) in the F2 generation, which was sustained until F10. This sensitization was less pronounced for Ag 2 S ENP exposures, indicating different toxicity mechanisms. Subtle changes in size and lifespan were also measured. In the recovery populations, the sensitivity to Ag ENPs and AgNO 3 resulting from the initial multigenerational exposure persisted. Their response sensitivity for all endpoints was most closely related to the last ancestral exposed generation (F5), rather than unexposed controls. The mechanisms of transgenerational transfer of sensitivity are probably organized through the epigenome, and we encourage others to investigate such effects as a priority for mechanistic toxicology.

show abstract

“…Ionizing radiation is known to induce oxidative stress, DNA damage, and apoptosis, which therefore constitute usual molecular markers for evaluating toxicity mechanisms (Knowles ; Simon et al ; Jaafar et al ; Gagnaire et al ; Praveen Kumar et al ; Sinha et al ). Significant effects in animals (fish, nematode, Daphnia ) in terms of survival, reproduction, and development have been observed (Knowles ; Simon et al ; Adam‐Guillermin et al ; Buisset‐Goussen et al ; Gagnaire et al ; Parisot et al ). Moreover, damage effects in fish have mainly been observed for early life stages, which are considered to be the most vulnerable to ionizing radiation.…”

Section: Introductionmentioning

confidence: 99%

“…Thirdly, the consequences of parental exposure for offspring generations have not yet been taken into account in the ERA. However, multigenerational studies have become of great interest (Buisset-Goussen et al 2014;Parisot et al 2015;Hurem et al 2017a;Lemos et al 2017). For fish, the progeny of adult zebrafish exposed to 53 mGy h -1 ( 60 Co gamma radiation) for 27 d showed a 100% mortality rate occurring at the gastrula stage (Hurem et al 2017a).…”

Section: Introductionmentioning

confidence: 99%

Adverse effects induced by chronic gamma irradiation in progeny of adult fish not affecting parental reproductive performance

Noëmie

Gagnaire

Frelon

et al. 2019

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Multigenerational studies have become of great interest in ecotoxicology since the consequence of parental exposure to contaminants on offspring generations was established in situ or in laboratory conditions. The present study mainly examined the chronic effects of external Cs‐137 gamma irradiation exposure at 4 dose rates (control, 0.5, 5, and 50 mGy h–1) on adult zebrafish (F0) exposed for 10 d and their progeny (F1) exposed or unexposed for 4 to 5 d. The main endpoints investigated included parental reproductive performance, embryo‐larval survival, DNA alterations, and reactive oxygen species (ROS) production in F0 and F1. No effects on reproductive success, fecundity, or egg fertilization rate were observed. However, drastic effects were observed on F1 exposed to 50 mGy h–1, resulting in a mortality rate of 100%. The drastic effects were also observed when the progeny was not irradiated. It was demonstrated that the sensitivity of the embryos was mainly attributable to parental irradiation. Moreover, these drastic effects induced by adult irradiation disappeared over time when 10 d–irradiated adults were placed in a nonirradiated condition. Alterations in larval DNA were observed for the 3 dose rates, and an increase of ROS production was also shown for the 2 lowest dose rates. The present study improves our understanding of the consequences of parental exposure conditions to the progeny. Furthermore, it provides an incentive to take transmitted generational effects into account in ecological risk assessments. Environ Toxicol Chem 2019;38:2556–2567. © 2019 SETAC

show abstract

Effects of chronic gamma irradiation: a multigenerational study using Caenorhabditis elegans

Cited by 48 publications

References 39 publications

Differential modification of the C. elegans proteome in response to acute and chronic gamma radiation: Link with reproduction decline

Differential modification of the C. elegans proteome in response to acute and chronic gamma radiation: Link with reproduction decline

Multigenerational exposure to silver ions and silver nanoparticles reveals heightened sensitivity and epigenetic memory inCaenorhabditis elegans

Adverse effects induced by chronic gamma irradiation in progeny of adult fish not affecting parental reproductive performance

Contact Info

Product

Resources

About