Effects of chorda tympani transection on long-term salt preference in hamsters

Barry, Michael A.; Larson, Dana; Frank, Marion E.

doi:10.1016/s0031-9384(96)80003-5

Cited by 11 publications

(2 citation statements)

References 38 publications

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“…These electrophysiological findings have corresponded with the documented importance of the CT in taste-guided behaviors related to sodium in rodents. Studies have shown that transection of the CT diminishes both natural and conditioned taste aversions to NaCl in rats (Chappell, St. John, & Spector, 1998;Sollars & Bernstein, 1994;Sollars, Sollars, & Bernstein, 1991;Yamamoto, Shimura, Sako, Yasoshima, & Sakai, 1994; but see and hamsters (Barry, Larson, & Frank, 1993;Barry, Larson, & Frank, 1996). Gustatory denervation of the anterior tongue also decreases the number of ingestive oromotor responses (i.e., taste reactivity) elicited by NaCl in rats (Grill, Schwartz, & Travers, 1992).…”

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confidence: 99%

The relative effects of transection of the gustatory branches of the seventh and ninth cranial nerves on NaCl taste detection in rats.

Blonde¹,

Garcea²,

Spector³

2006

Behavioral Neuroscience

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Chorda tympani nerve (CT) transection in rats severely impairs NaCl taste detection. These rats can detect higher concentrations of NaCl, however, suggesting that remaining oral nerves maintain some salt sensibility. Rats were tested in a gustometer with a 2-response operant taste-detection task before and after sham surgery (n = 5), combined transection of the CT and the greater superficial petrosal nerves (GSP; 7x, n = 6), or transection of the glossopharyngeal nerve (GL; 9x, n = 4). Thresholds did not significantly change after sham surgery. Although the GL responds to NaCl and innervates nearly 60% of total taste buds, 9x surgery had no effect. However, 7x surgery increased NaCl detection threshold by approximately 2.5 log(10) units, greater than that reported for CT transection alone. These results suggest that the GSP contributes to NaCl sensitivity in rats and also demonstrate that the GL and perhaps the superior laryngeal and lingual nerve proper can maintain some NaCl detectability at high concentrations. These findings confirm the primacy of the 7th nerve relative to the 9th nerve in sensibility of NaCl in the rat model.

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confidence: 99%

The relative effects of transection of the gustatory branches of the seventh and ninth cranial nerves on NaCl taste detection in rats.

Blonde¹,

Garcea²,

Spector³

2006

Behavioral Neuroscience

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“…Furthermore, the magnitude and chemospecificity of a depletion-induced sodium appetite is compromised in rats after transection of the CT (Breslin, Spector, & Grill, 1993; Breslin, Spector, & Grill, 1995; Frankmann, Sollars, & Bernstein, 1996; Markison, St. John, & Spector, 1995; O'Keefe, Schumm, & Smith, 1994; Sollars & Bernstein, 1992). Damage to this nerve has also been shown to cause impairments in behavioral responsiveness to NaCl in the hamster (Barry, Larson, & Frank, 1993, 1996; Yamamoto, Matsuo, Kiyomitsu, & Kitamura, 1988).…”

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confidence: 99%

Chorda tympani nerve transection, but not amiloride, increases the KCl taste detection threshold in rats.

Geran¹,

Guagliardo²,

Spector³

1999

Behavioral Neuroscience

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Water-restricted rats were trained to press one lever after KCl presentation and the other lever after distilled water. Water reinforcement was given after each correct response, and a time-out followed each incorrect response. Rats were trained and tested on KCl stimuli of varying concentrations. Threshold was defined as the KCl concentration corresponding to 1/2 the maximum asymptote of performance for each rat. The geometric mean KCl detection threshold for all rats was 0.033 M KCl. Rats that had the chorda tympani nerve (CT) bilaterally transected showed an average increase in KCl threshold of approximately 0.60 log10 units, whereas sham-operated rats showed no change. Control rats retested with 100 microM amiloride added to all KCl concentrations and water displayed no change in threshold. These results suggest that although the CT contributes significantly to the rat's sensitivity to KCl, amiloride-sensitive taste transduction pathways do not.

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Olfaction and Taste

Lorenzo

Youngentob

2003

Handbook of Psychology

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The ability to detect and interpret the chemicals in our environment affects nearly every aspect of our survival. The flavor of our food, i.e., the combination of its taste and smell, is used both to prompt ingestion of nutrients and to protect us from ingesting or inhaling toxins. In the study of taste and olfaction, there are certain as yet unresolved questions that date from the very earliest research into these areas. For example, there is continued debate on the nature of primary stimuli, on the mechanisms of transduction, and on the ways in which stimuli are encoded and interpreted by the nervous system. In this review, the current thinking about these questions, as well as some recent data that may help to resolve them, are outlined. Data from both animal and human models are used to show how technological advances, particularly in the realm of molecular neurobiology, are providing the tools for a new and more complete understanding of how we taste and smell the chemicals in our environment.

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Effects of chorda tympani transection on long-term salt preference in hamsters

Cited by 11 publications

References 38 publications

The relative effects of transection of the gustatory branches of the seventh and ninth cranial nerves on NaCl taste detection in rats.

The relative effects of transection of the gustatory branches of the seventh and ninth cranial nerves on NaCl taste detection in rats.

Chorda tympani nerve transection, but not amiloride, increases the KCl taste detection threshold in rats.

Olfaction and Taste

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