Effects of cell phone radiation on lipid peroxidation, glutathione and nitric oxide levels in mouse brain during epileptic seizure

Eşmekaya, Meriç Arda; Tuysuz, Mehmet Zahid; Tomruk, Arin; Canseven, Ayşe G.; Yücel, Engin; Aktuna, Zuhal; Keskil, Semih; Seyhan, Nesrin

doi:10.1016/j.jchemneu.2016.01.011

Cited by 14 publications

(6 citation statements)

References 32 publications

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“…In the context of neurological disorders, the immediate response to short-term RF-EMF exposure was also assessed. In a mouse model with chemically induced epilepsy, the influence of RF-EMF on oxidative stress caused by epilepsy was investigated, exposing them (900 MHz, SAR: 0.3 W/kg) for 15 and 30 min before and/or after induction of the epileptic seizures [62]. While the antioxidant activity was significantly reduced, markers for ROS and lipid peroxidation in the brain were induced, whereby the time-point of RF-EMF exposure was not pivotal for the observed effects.…”

Section: Observations In Emf-exposed Animalsmentioning

confidence: 99%

Manmade Electromagnetic Fields and Oxidative Stress—Biological Effects and Consequences for Health

Schuermann

Mevissen

2021

IJMS

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Concomitant with the ever-expanding use of electrical appliances and mobile communication systems, public and occupational exposure to electromagnetic fields (EMF) in the extremely-low-frequency and radiofrequency range has become a widely debated environmental risk factor for health. Radiofrequency (RF) EMF and extremely-low-frequency (ELF) MF have been classified as possibly carcinogenic to humans (Group 2B) by the International Agency for Research on Cancer (IARC). The production of reactive oxygen species (ROS), potentially leading to cellular or systemic oxidative stress, was frequently found to be influenced by EMF exposure in animals and cells. In this review, we summarize key experimental findings on oxidative stress related to EMF exposure from animal and cell studies of the last decade. The observations are discussed in the context of molecular mechanisms and functionalities relevant to health such as neurological function, genome stability, immune response, and reproduction. Most animal and many cell studies showed increased oxidative stress caused by RF-EMF and ELF-MF. In order to estimate the risk for human health by manmade exposure, experimental studies in humans and epidemiological studies need to be considered as well.

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Section: Observations In Emf-exposed Animalsmentioning

confidence: 99%

Manmade Electromagnetic Fields and Oxidative Stress—Biological Effects and Consequences for Health

Schuermann

Mevissen

2021

IJMS

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“…The primary search yielded 7766 studies (PubMed, n = 1227; Scopus, n = 6470; Google Scholar, n = 69). Only 33 studies met all the inclusion criteria and were included in the current systematic review 15–47 (Figure 1). Table 1 shows a summary of these studies.…”

Section: Resultsmentioning

confidence: 99%

“…However, the relevance of these small physiological changes remains unclear and mechanistic explanations are still lacking 48 . On the other hand, many animal 19,22,24,26,28,30,34,37,39,42 and human studies 18,27,29,38,43–45 have suggested that exposure to RF‐EMF may be harmful in patients with epilepsy. This harm may show itself either with an increase in seizure frequency 37,38 or with cognitive problems in PWE 43 .…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, many animal 19,22,24,26,28,30,34,37,39,42 and human studies 18,27,29,38,43–45 have suggested that exposure to RF‐EMF may be harmful in patients with epilepsy. This harm may show itself either with an increase in seizure frequency 37,38 or with cognitive problems in PWE 43 . However, there is a lack of good evidence that mobile phone RF‐EMF affects cognitive functions in humans in general 48 .…”

Section: Discussionmentioning

confidence: 99%

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Smart devices/mobile phone in patients with epilepsy? A systematic review

et al. 2021

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We systematically reviewed the existing literature on the safety of the use of smartphone, mobile phone/Internet, and Wi‐Fi by people with epilepsy (PWE), according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) statement. Scopus, MEDLINE, and Google Scholar from the inception to April 9, 2021 were searched. These key words were used “epilepsy” OR “seizure” AND “Mobile Phone” OR “Cell Phone” OR “Smartphone” OR “Wi‐Fi” OR “Electromagnetic” OR “Radiation.” The primary search yielded 7766 studies; 33 studies were related. In total, 19 manuscripts were based on animal/computational studies and 14 articles reported human investigations. Among animal studies, 10 articles suggested detrimental effects by electromagnetic fields (EMFs) on brain function/seizure activity, while nine studies negated this hypothesis. Among human studies, seven studies suggested detrimental effects by EMFs on brain function/seizure activity, while seven studies negated this hypothesis. None of the studies provided a good level of evidence. In one human study, all seven patients with epilepsy and abnormal EEG during the sham exposure, had an increase in the number of epileptic events with exposure to mobile phone radiation. In another study of the detrimental effects of smart technology device overuse among school students, an association was found between reporting seizures and the hours of smart technology device use. While high‐quality evidence on the safety of the use of smartphone, mobile phone/Internet, and Wi‐Fi in PWE is lacking, prudent use of these technologies, including using wired hand‐free sets or other exposure‐reducing measures is recommended.

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“…[11][12][13][14][15][16] The brain is especially susceptible to oxidative stress because of its relatively low antioxidant enzymes. 17 In addition, elevated total Hcy has an increased risk for other disease, such as vascular diseases and dementia. 18 Furthermore, Hcy acts as a glutamate agonist on the N-methyl-D-aspartate (NMDA) receptor.…”

Section: Hyperhomocysteinemia (Hhcy)/oxidative Stressmentioning

confidence: 99%

Therapeutic Cocktail Approach for Treatment of Hyperhomocysteinemia in Alzheimer’s Disease

et al. 2018

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In the United States, Alzheimer's disease (AD) is the most common cause of dementia, accompanied by substantial economic and emotional costs. During 2015, more than 15 million family members who provided care to AD patients had an estimated total cost of 221 billion dollars. Recent studies have shown that elevated total plasma levels of homocysteine (tHcy), a condition known as hyperhomocysteinemia (HHcy), is a risk factor for AD. HHcy is associated with cognitive decline, brain atrophy, and dementia; enhances the vulnerability of neurons to oxidative injury; and damages the blood–brain barrier. Many therapeutic supplements containing vitamin B12 and folate have been studied to help decrease tHcy to a certain degree. However, a therapeutic cocktail approach with 5-methyltetrahydrofolate, methyl B12, betaine, and N-acetylcysteine (NAC) have not been studied. This novel approach may help target multiple pathways simultaneously to decrease tHcy and its toxicity substantially.

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Effects of cell phone radiation on lipid peroxidation, glutathione and nitric oxide levels in mouse brain during epileptic seizure

Cited by 14 publications

References 32 publications

Manmade Electromagnetic Fields and Oxidative Stress—Biological Effects and Consequences for Health

Manmade Electromagnetic Fields and Oxidative Stress—Biological Effects and Consequences for Health

Smart devices/mobile phone in patients with epilepsy? A systematic review

Therapeutic Cocktail Approach for Treatment of Hyperhomocysteinemia in Alzheimer’s Disease

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