Brain disorders are a leading cause of global disability. With the increasing global proliferation of smart devices and connected objects, the use of these technologies applied to research and clinical trials for brain disorders has the potential to improve their understanding and create applications aimed at preventing, early diagnosing, monitoring, and creating tailored help for patients. This chapter provides an overview of the data these technologies offer, examples of how the same sensors are applied in different applications across different brain disorders, and the limitations and considerations that should be taken into account when designing a solution using smart devices, connected objects, and sensors.