Effects of carprofen on renal function and results of serum biochemical and hematologic analyses in anesthetized dogs that had low blood pressure during anesthesia

Abstract

Carprofen administered IV before or during anesthesia did not cause detectable significant adverse effects on renal function or results of serum biochemical and hematologic analyses in healthy Beagles with low blood pressure during anesthesia.

Effects of preoperative administration of carprofen on renal function and hemostasis in dogs undergoing surgery for fracture repair

“…Another possible explanation for the lack of clinically important renal effects of carprofen may have been that carprofen did not exert an inhibitory effect on COX in the kidneys and therefore preserved the protective function of local prostaglandins during general anesthesia. Our results are similar to those of studies [14][15][16] in which renal function was evaluated after administration of carprofen to healthy anesthetized dogs with or without concomitant surgery or to healthy dogs with low blood pressure that were anesthetized. Our study differs in that carprofen was administered to dogs with traumatic injuries that had plasma concentrations of urea or creatinine (or both) within reference ranges but had GFRs or UP:UC (or both) that often were not within the respective reference ranges before surgery.…”

“…Before surgery, most dogs in both groups had ALT (group 1: range, 16 Plasma bilirubin concentration was significantly higher in dogs of group 1 (range, 0.12 to 1.00 mg/dL [median, 0.22 mg/dL]) than in dogs of group 2 (range, 0 to 0.21 mg/dL [median, 0.15 mg/dL]) on day 4. However, bilirubin concentration did not differ significantly among time points within both groups.…”

“…13 However, carprofen did not cause clinically important adverse effects on renal function in healthy anesthetized dogs, even in dogs with low blood pressure during anesthesia. [14][15][16] Furthermore, NSAIDs prevent formation of thromboxane A2 in platelets, which leads to impaired platelet adhesion and increases the propensity for hemorrhage. 17 Preoperative use of NSAIDs may increase the incidence of hemorrhage during the perioperative period.…”

2015 AAHA/AAFP Pain Management Guidelines for Dogs and Cats

“…When administered before anesthesia in healthy dogs with controlled modest hypotension, no adverse effect on renal function was detected. 30,31 However, because some dogs in those studies did develop changes in renal parameters, the importance of maintaining a normotensive state during anesthesia is considered paramount when utilizing preoperative NSAiDs. Preoperative administration in dogs is superior in efficacy to postoperative use, consistent with results of multiple studies performed in humans.…”

Pain management in cat

“…sc, πλεονεκτεί της μετεγχειρητικής χορήγησης πε-θιδίνης (Lascelles et al 1995, Balmer et al 1998) ή βου-τορφανόλης (Al-Gizawiy and Rude 2004). Υπενθυμί ζεται ότι στο σκΰλο βρέθηκε πως, σε ό,τι αφορά στη νε φρική λειτουργία, η καρπροφαίνη είναι ασφαλής ακό μη και σε συνθήκες χαμηλών αρτηριακών πιέσεων (Bostrom et al 2002, Crandell et al 2004. Έτσι, παρότι η εξαγωγή συμπερασμάτων από ένα ζωικό είδος σε άλλο, ειδικά σε ό,τι αφορά στα ΜΣΑΦ, είναι επισφα λής, η ομοιότητα μεταξύ σκύλου και γάτας στην ειδι κότητα αναστολής της COX-2 από την καρπροφαίνη μπορεί να οδηγήσει στην υπόθεση ότι και στη γάτα η καρπροφαίνη είναι εξίσου ασφαλής αναφορικά με τη νεφρική λειτουργία κατά τη διάρκεια της αναισθησίας.…”