Effects of calcium ions on titanium surfaces for bone regeneration

Anitua, Eduardo; Piñas, Laura; Murias, Alia; Prado, Roberto; Tejero, Ricardo

doi:10.1016/j.colsurfb.2015.04.006

Cited by 46 publications

(43 citation statements)

References 35 publications

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“…Liu et al [119] evaluated cytocompatibility and early osseointegration of an innovative Ti-24 Nb-4 Zr-7.9 Sn surface. According to Anitua and colleagues [120] based on in vitro and in vivo analyses, titanium implants modified with calcium ions represented a valuable route to improve osseointegration. Calcium ions, indeed, prevent adventitious hydrocarbon passivation of the oxide layer and produce a durable chemical and nano-topographical modification of the titanium oxide interface.…”

Section: Nanostructured Surface Modificationsmentioning

confidence: 99%

“…Table 1 provides a synthetic reference on the different types of biological effects that have been reviewed in this section, with proper references. Mineral substituted hydroxyapatite and carbon nano tube [110] Nanostructured surface modifications TiO 2 nanorods [117]; ribbonlike octacalcium in vitro [118]; amino-terminated films (PPAAm, PPEDA and PSN) [59]; PPEDA [60]; PPAAm [61,62]; PPAAm and PPAAc [69]; PPAAc, PPAAm and PPAAl films [72]; PCL and P DD LLA [71]; TiN [122]; porous tantalum [123] Ti-24 Nb-4 Zr-7.9 Sn [119]; Calcium [120] …”

Section: Nanostructured Surface Modificationsmentioning

confidence: 99%

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Surface Treatments and Functional Coatings for Biocompatibility Improvement and Bacterial Adhesion Reduction in Dental Implantology

et al. 2016

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Surface modification of dental implants is a key process in the production of these medical devices, and especially titanium implants used in the dental practice are commonly subjected to surface modification processes before their clinical use. A wide range of treatments, such as sand blasting, acid etching, plasma etching, plasma spray deposition, sputtering deposition and cathodic arc deposition, have been studied over the years in order to improve the performance of dental implants. Improving or accelerating the osseointegration process is usually the main goal of these surface processes, but the improvement of biocompatibility and the prevention of bacterial adhesion are also of considerable importance. In this review, we report on the research of the recent years in the field of surface treatments and coatings deposition for the improvement of dental implants performance, with a main focus on the osseointegration acceleration, the reduction of bacterial adhesion and the improvement of biocompatibility.

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Section: Nanostructured Surface Modificationsmentioning

confidence: 99%

Section: Nanostructured Surface Modificationsmentioning

confidence: 99%

Surface Treatments and Functional Coatings for Biocompatibility Improvement and Bacterial Adhesion Reduction in Dental Implantology

et al. 2016

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“…Studies in vitro showed that increased concentrations of Ca and P ions in the medium contributed to proliferation and differentiation of pre-osteoblasts and MSCs to osteoblasts, leading to new bone formation [39][40][41] . Ti implant surfaces modified with Ca ions stimulated osteoblasts attachment, proliferation and differentiation, and improved implant osseointegration 42) . In addition, Ca and P ions-co-immobilization onto Ti implant could stimulate the response of pre-osteoblasts, with greater alkaline phosphatase activity and bone-like nodule formation 43) .…”

Section: Discussionmentioning

confidence: 97%

Calcium, Phosphorus and Oxygen Around Implant at Early Osseointegration in Hyperlipidemic Rats

Liu

Wang

Dong

et al. 2019

J. Hard Tissue Biology.

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The study was to observe dental implant osseointegration at early stage and analysis the influencement of the ratio of calcium and phosphorus variation on osseointegration in hyperlipidemic rats. Wistar rats were randomly divided into control group with normal diet and experimental group with high fat diet. 8 weeks later, serum lipid levels was detected and titanium implants were placed into bilateral femurs. At day1, 3, 5 after implant, rats were sacrificed and 5 mm bone with implants was obtained. hard tissue slices and methylene blue-acid fuchsin staining were performed to observe the interface of bone-implant. And energy disperse X-ray spectrometer (EDS) was used to measure the percentage of oxygen and the ratio of calcium and phosphorus. All rats in experimental group were successfully induced into hyperlipidemic status. Histological results revealed less osteoblasts and trabecular bone, but more osteoclasts and trabecular space in experimental group than those in control group. Higher content of oxygen and lower ration of calcium and phosphorus were also observed in experimental group than those in control group (P<0.05). Hyperlipidemia could hinder implant osseointegration at early stage after implantation. This inhibition might be closely related to higher content of oxygen and lower ratio of calcium and phosphorus.

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“…Calcium ions at titanium oxide implant surfaces form a hydrated layer that has been reported to promote surface‐based provisional matrix formation, platelet activation, and osseointegration in vivo . As calcium ions are also responsible for the binding of several proteins, the presence of these ions may in turn increase the bacterial affinity for the surfaces.…”

Section: Introductionmentioning

confidence: 99%

“…Calcium ions at titanium oxide implant surfaces form a hydrated layer that has been reported to promote surfacebased provisional matrix formation, platelet activation, and osseointegration in vivo. [26][27][28] As calcium ions are also responsible for the binding of several proteins, the presence of these ions may in turn increase the bacterial affinity for the surfaces. However, supported on the studies that prove the antibacterial effects of some calcium-binding proteins and platelet-derived microparticles of blood plasma, [29][30][31][32] we hypothesize that calcium-ion-modified surfaces may also significantly limit bacterial adhesion and biofilm formation.…”

Section: Introductionmentioning

confidence: 99%

Balancing microbial and mammalian cell functions on calcium ion‐modified implant surfaces

et al. 2017

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Implant integration is a complex process mediated by the interaction of the implant surface with the surrounding ions, proteins, bacteria, and tissue cells. Although most implants achieve long-term bone-tissue integration, preventing pervasive implant-centered infections demands further advances, particularly in surfaces design. In this work, we analyzed classical microrough implant surfaces (only acid etched, AE; sandblasted then acid etching, SB 1 AE) and a new calcium-ion-modified implant surface (AE 1 Ca) in terms of soft-and hard-tissue integration, bacterial adhesion, and biofilm formation. We cultured on the surfaces primary oral cells from gingiva and alveolar bone, and three representative bacterial strains of the oral cavity, emulating oral conditions of natural saliva and blood plasma. With respect to gingiva and bone cells and in the presence of platelets and plasma proteins, AE 1 Ca surfaces yielded in average 86% higher adhesion, 44% more proliferation, and triggered 246% more synthesis of extracellular matrix biomolecules than AE-unmodified controls. Concomitantly, AE 1 Ca surfaces regardless of conditioning with saliva and/or blood plasma showed significantly less bacterial adhesion (67% reduction in average) and biofilm formation (40% reduction in average) than unmodified surfaces. These results highlight the importance of a calcium-rich hydrated interface to favor mammalian cell functions over microbial colonization at implant surfaces.

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Effects of calcium ions on titanium surfaces for bone regeneration

Cited by 46 publications

References 35 publications

Surface Treatments and Functional Coatings for Biocompatibility Improvement and Bacterial Adhesion Reduction in Dental Implantology

Surface Treatments and Functional Coatings for Biocompatibility Improvement and Bacterial Adhesion Reduction in Dental Implantology

Calcium, Phosphorus and Oxygen Around Implant at Early Osseointegration in Hyperlipidemic Rats

Balancing microbial and mammalian cell functions on calcium ion‐modified implant surfaces

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