Effects of Bread with Nigella Sativa on Lipid Profiles, Apolipoproteins and Inflammatory Factor in Metabolic Syndrome Patients

Abstract

Nigella sativa (N.sativa) has been used in traditional medicine and many studies have been performed in different communities in order to reveal the effects of it on medical disorders and chronic diseases. The aim of this study was to investigate the effects of bread with N. Sativa on lipid profiles, apolipoproteins, and inflammatory factors in metabolic syndrome (MetS) patients. A randomized, double-blind, cross-over and clinical trial was conducted in 51 MetS patients of both sexes with age group of 20-65 years old in Chaloos, north of Iran. Patients were randomly divided in two groups. In phase 1, intervention group (A, n = 27) received daily a bread with N. sativa and wheat bran and control group (B, n = 24) received the same bread without N. sativa for 2 months. After 2 weeks of wash out period, phase 2 was started with switch the intervention between two groups. Measuring of lipid profiles, apolipoproteins and inflammatory factor was performed for all patients before and after two phases. In this study, treatment, sequence and time effects of intervention were evaluated and revealed that consumption of bread with N. sativa has no significant treatment and time effects on triglyceride (TG), cholesterol (CHOL), low density lipoprotein (LDL), high density lipoprotein (HDL), apolipoprotein (APO)-A, APO-B and high-sensitivity C-reactive protein (p > 0.05). Sequence effect was significant on CHOL, LDL, APO-A, and APO-B (p < 0.05) but was not significant on other parameters (p > 0.05). Consumption of bread with N. sativa has no a significant effect on lipid profiles, apolipoproteins and inflammatory factor in MetS patients.

The beneficial health effects of Nigella sativa on Helicobacter pylori eradication, dyspepsia symptoms, and quality of life in infected patients: A pilot study

“…In our study, the serum levels of IL‐8, hs‐CRP, and MDA did not change significantly between and within groups after the intervention. In line with our findings, supplementation with N. sativa did not have any effect on inflammatory and oxidative stress markers in patients with metabolic syndrome, obesity, and rheumatoid arthritis (Datau, Surachmanto, Pandelaki, & Langi, ; Hadi, Kheirouri, Alizadeh, Khabbazi, & Hosseini, ; Mohtashami, Mahaki, Azadbakht, & Entezari, ). In contrast, Namazi et al showed that consumption of N. sativa oil with a low‐calorie diet caused reduction in the hs‐CRP and TNFα levels.…”

Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta‐analysis of randomized controlled clinical trials

“…of black seed and 3 g of wheat bran-had no effects on triglyceride, total cholesterol, LDL, and HDL levels after 2 months in patients with metabolic syndrome (Mohtashami et al, 2016). In a study by , consumption of N. sativa powder-1 g after breakfast every day for 2 months in menopausal women changed lipid profiles.…”

Nigella sativa and Trigonella foenum-graecum Supplemented Chapatis Safely Improve HbA1c, Body Weight, Waist Circumference, Blood Lipids, and Fatty Liver in Overweight and Diabetic Subjects: A Twelve-Week Safety and Efficacy Study

“…Furthermore, MetS patients consuming 3 g powdered N. sativa in 100 g bread daily for 2 months exhibited no change ( P > .05) in TC, LDL, HDL, TG, or LDL/HDL. 18 …”

“…Furthermore, MetS patients consuming 3 g powdered N. sativa in 100 g bread daily for 2 months exhibited no change (P > .05) in TC, LDL, HDL, TG, or LDL/HDL. 18 Lipidic indexes ''Atherogenic and diabetogenic indexes'' derived from lipoprotein ratios such as TC/HDL, LDL/HDL, VLDL/ HDL, and TG/HDL have been validated as biomarkers of (1) cardiovascular disease, (2) arterial stiffness, and (3) insulin resistance in OW, normotensive, and DM subjects. [47][48][49][50][51] The -5.85% (-10.5% to -1.15%; P = .0161) and -7.44% (-13.7% to -1.18%; P = .0211) decreases, respectively, in TC/HDL and TG/HDL reflected improved glycemic control by NFC in DM and DM/OW individuals, as well as decreased cardiovascular disease risk and heart failure risk.…”

“…16 Fenugreek is also used to enhance the sensory quality of foods as a stabilizer, emulsifier, and adhesive. 15 The recognition of the wide-ranging, potential health benefits of N. sativa and its high margin of safety has encouraged scientists to incorporate N. sativa into food matrices such as bread containing ground seeds 17,18 and cookies formulated with fixed seed oil or thymoquinone. [19][20][21] Fenugreek bread has also been suggested as a functional food for the management of T2D.…”