Effects of Bread with Nigella Sativa on Blood Glucose, Blood Pressure and Anthropometric Indices in Patients with Metabolic Syndrome

Abstract

Nigella sativa ( N. sativa ) is one of important herbal foods in traditional medicine and many studies have conducted to show the effects of this plant on several diseases. The goal of this study was the evaluation of effects of bread with N. Sativa on clinical parameters such as blood glucose, blood pressure (BP) and anthropometry indices in subjects with metabolic syndrome (MetS). A study as double-blind, cross-over, randomized clinical trial was performed in 51 MetS patients in Chalus, north region of Iran. After dividing of patients randomly in 2 groups, in phase 1, intervention group (A, n = 27) used daily a bread with N. sativa and control group (B, n = 24) used the same bread but without N. sativa for 2 months. After considering of 15 day wash out period, phase 2 was began with changing of position of 2 groups. Measuring of parameters including fasting blood glucose (FBG), systolic blood pressure (SBP), diastolic blood pressure (DBP), weight, body mass index (BMI), and waist circumference (WC) was done before and after of 2 phases. After evaluation of treatment, sequence and time effects of intervention on parameters, it is shown that consumption of this bread has not significant treatment effect (as main effect) on FBG, SBP, DBP, WC, weight, and BMI (p > 0.05). Sequence effect on FBG, weight, WC, and BMI was significant (p < 0.05), but was not on BP. Time effect was only significant for DBP. Consumption of bread with N. sativa in MetS patients has not significant effect on FBG, BP, weight, WC, and BMI. Trial Registration Iranian Registry of Clinical Trials Identifier: IRCT2015041821815N1

Nigella Plants – Traditional Uses, Bioactive Phytoconstituents, Preclinical and Clinical Studies

“…Conversely, a recent cross-over study (2 months treatment, 2 weeks washout period) evaluated the effects of N. sativa , as a form of traditional bread spiked with seeds (2 g), on FBG, BP and anthropometric indices (BW, waist circumference or WC, and BMI body mass index) in patients with metabolic syndrome. It found no significant effect between the mean of changes of parameters in the beginning and end of study (time effect), with the exception of diastolic BP ( Mohtashami, 2019 ).…”

Nigella sativa and Trigonella foenum-graecum Supplemented Chapatis Safely Improve HbA1c, Body Weight, Waist Circumference, Blood Lipids, and Fatty Liver in Overweight and Diabetic Subjects: A Twelve-Week Safety and Efficacy Study

“…MetS patients consuming 3 g powdered N. sativa daily in 100 g bread for 2 months did not exhibit significant decreases in FBG. 17 In the second study, fenugreek administered as a single serving of 56 g of bread containing 2.8 g fenugreek failed to significantly affect PPBG in eight diet-controlled diabetics, although a decrease in insulin secretion over 2 h versus placebo was reported. 25 …”

“…A lack of hypotensive effect in T2D subjects was also reported for a polyherbal encapsulated formulation of N. sativa and fenugreek that additionally contained Allium sativum , Aloe vera , P. psyllium , and S. marianum administered over 40 days. 29 Using a food matrix consisting of 100 g bread containing 3 g N. sativa powder, Mohtashami 17 reported no effect on SBP or DBP in 51 subjects with MetS, who consumed the formulated bread for 2 months.…”

“…16 Fenugreek is also used to enhance the sensory quality of foods as a stabilizer, emulsifier, and adhesive. 15 The recognition of the wide-ranging, potential health benefits of N. sativa and its high margin of safety has encouraged scientists to incorporate N. sativa into food matrices such as bread containing ground seeds 17,18 and cookies formulated with fixed seed oil or thymoquinone. [19][20][21] Fenugreek bread has also been suggested as a functional food for the management of T2D.…”

Effects of Nigella sativa on Performance, Blood Profiles, and Antibody Titer against Newcastle Disease in Broilers

“…The results obtained during this study ( Table 5 ) on the level of serum glucose of chickens are in agreement with recent reports [ 29 , 40 ] but in disagreement with other reports [ 41 , 42 ]. Some controversial observations could be explained where the type of the extract, whole seed, and duration of consumption may exert different effects on glucose level as has been observed by Mohtashami [ 60 ] who reported that N . sativa did not significantly affect the fasting blood glucose level but significantly decreased its levels during oral glucose tolerance test (OGTT) when compared to diabetic control by affecting the time course of glucose absorption from the intestine.…”