Nigella Plants – Traditional Uses, Bioactive Phytoconstituents, Preclinical and Clinical Studies

Salehi, Bahare; Quispe, Cristina; Imran, Muhammad; Ul-Haq, Iahtisham; Živković, Jelena; Abu‐Reidah, Ibrahim M.; Sen, Surjit; Taheri, Yasaman; Acharya, Krishnendu; Azadi, Hamed; Contreras, María del Mar; Segura‐Carretero, Antonio; Mnayer, Dima; Sethi, Gautam; Martorell, Miquel; Razis, Ahmad Faizal Abdull; Usman, Sunusi; Kamal, Ramla Muhammad; Suleria, Hafiz Ansar Rasul; Sharifi‐Rad, Javad

doi:10.3389/fphar.2021.625386

Cited by 53 publications

(44 citation statements)

References 222 publications

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“…For the chemical composition, it was reported that N. sativa contains more bioactive compounds like phenolic acids, flavonoids, and thymoquinone considered responsible for its biological activities. These compounds have not been identified in N. orientalis and might explain the differences in our obtained results (Farag, Gad, Heiss, & Wessjohann, 2014; Salehi et al, 2021).…”

Section: Discussioncontrasting

confidence: 69%

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Analgesic and antiinflammatory effects of Nigella orientalis L. seeds fixed oil: Pharmacological potentials and molecular mechanisms

Eldjoudi

Ruiz-Fernández

González-Rodríguez

et al. 2022

Phytotherapy Research

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Nigella species have been widely used in traditional medicine. The aim of this study was to evaluate the antiinflammatory and analgesic potentials of Nigella orientalis L. seeds fixed oil (NOO). The acetic acid writhing test and the formaldehyde-induced licking paw were performed to assess the analgesic activity of the oil. The antiinflammatory activity was first evaluated in vitro by the erythrocyte membrane stabilization then in vivo by xylene-and carrageenan-induced ear and paw edema, respectively. To further understand the molecular mechanism of action of the Nigella extract, lipopolysaccharide-activated RAW 264.7 macrophages were used. Nitric oxide (NO) production was measured by Griess reaction and cell viability by MTT assay. The gene and protein expression of inflammatory mediators were assessed by RT-PCR and western blot, respectively. NOO exerted a potent analgesic effect in in vivo models of writhing test and induced edema. The analyzed molecular mechanisms revealed a role for NO and prostaglandins as molecules mediating the pharmacological effects of the extract through a mechanism involving nuclear factor-κB and mitogen-activated protein kinases. This study demonstrates, for the first time, that the fixed oil of N. orientalis has strong antinociceptive and antiinflammatory properties and might be a promising agent for the treatment of certain inflammation-related diseases.

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Section: Discussioncontrasting

confidence: 69%

“…These compounds have not been identified in N. orientalis and might explain the differences in our obtained results (Farag, Gad, Heiss, & Wessjohann, 2014;Salehi et al, 2021).…”

Section: Effect Of Noo On the Viability Of Raw 2647 Murine Macrophagescontrasting

confidence: 69%

Analgesic and antiinflammatory effects of Nigella orientalis L. seeds fixed oil: Pharmacological potentials and molecular mechanisms

Eldjoudi

Ruiz-Fernández

González-Rodríguez

et al. 2022

Phytotherapy Research

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“…Decreased viral load and improved liver function were similarly reported in another study by Barakat et al (2013) where HCV patients received capsules of Nigella sativa oil (450 mg) three times a day over 3 months. Furthermore, Thymoquinone has been studied for benefits other than anti-inflammatory effects which are beyond the scope of this review ( Mostofa et al, 2017 ; Mohammed and Islam, 2018 ; Shanmugam et al, 2018 ; Jehan et al, 2020 ; Leong et al, 2021 ; Salehi et al, 2021 ).…”

Section: Scientific Reportmentioning

confidence: 99%

Thymoquinone’s Antiviral Effects: It is Time to be Proven in the Covid-19 Pandemic Era and its Omicron Variant Surge

et al. 2022

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The COVID-19 pandemic has impacted every country in the world. With more than 400 million cases and more than 5.5 million deaths. The FDA either approved or authorized the emergency use for three vaccines against COVID-19. The treatment options of COVID-19 are very limited. Multiple complementary and alternative medicine modalities were suggested to be efficacious in the treatment of COVID-19 such as Thymoquinone. The effects of Thymoquinone have been examined and multiple studies indicate a promising beneficial effect. However, the current body of research is limited in terms of its scope, quality, and quantity. While higher-quality studies are required, physicians do not routinely recommend the use of marketed supplements of natural products, including Thymoquinone for COVID-19. Given the numerous suggested positive effects of Thymoquinone, including anti-inflammatory and antimicrobial properties, additional research is required to confirm or refute these promising benefits. Complementary and alternative medicine is an area that requires additional evidence-based practice and research to confirm effects observed in clinical practice.

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“…A metabolite library of 54 structurally diverse phytomolecules was constructed through a literature survey to identify potential CHIKV treatments [17,18] (Supplementary Table 1). The chemical and structural properties such as molecular weight, chemical formula, and canonical smiles of these metabolites were retrieved from the PubChem Database [19].…”

Section: Metabolite Librarymentioning

confidence: 99%

Computational probing of Nigella sativa bioactive metabolites against chikungunya nsP2 cysteine protease

Kumar¹,

Choudhir

Vimala

et al. 2022

Preprint

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Background and Aim: Instances of chikungunya reported throughout the world in the past two decades of the present century. There is a lack of effective medicine or vaccine for chikungunya treatment. Non-structural protein, the nsP2 cysteine protease (nsP2pro) is an attractive target for inhibitors. It is a key enzyme for proteolytic cleavage of polyprotein precursors and produces functional proteins for replication and multiplication of the virus. Bioactive metabolites from Nigella sativa L; a popular spice and well-known medicinal plant, were selected for the current study against nsP2pro to search for potent non-toxic natural inhibitors of nsP2pro. Experimental procedure: Out of 54 bioactive metabolites from N. sativa 27 qualified drug likeliness properties. Virtual screening of 27 selected molecules was performed using AutoDock Vina. Top four molecules Kaempferol, (-)-Epicatechin, (+)-Catechin, and Apigenin with the least binding energy were taken for molecular docking employing AUTODOCK4. These metabolites were subjected to molecular dynamics simulation and MMPBSA, and the resilience of protein-ligand complexes had been assessed in terms of RMSD, RMSF, Rg, SASA, and hydrogen bonding. Results and Conclusions: Drug likeliness, molecular docking, molecular dynamics simulation properties, and MMPBSA analyses made clear that Kaempferol, (-)- Epicatechin, (+)- Catechin, and Apigenin all seem to be potential nsP2pro potent inhibitors and strong candidates for chikungunya virus drug development.

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Nigella Plants – Traditional Uses, Bioactive Phytoconstituents, Preclinical and Clinical Studies

Cited by 53 publications

References 222 publications

Analgesic and antiinflammatory effects of Nigella orientalis L. seeds fixed oil: Pharmacological potentials and molecular mechanisms

Analgesic and antiinflammatory effects of Nigella orientalis L. seeds fixed oil: Pharmacological potentials and molecular mechanisms

Thymoquinone’s Antiviral Effects: It is Time to be Proven in the Covid-19 Pandemic Era and its Omicron Variant Surge

Computational probing of Nigella sativa bioactive metabolites against chikungunya nsP2 cysteine protease

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